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All Journal Jurnal Ilmu Kesehatan dan Gizi Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Fany Raihan Padilah
Universitas Muhammadiyah Surakarta
Health Professions Nursing Public Health

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Pengaruh Konsumsi Channa Striata terhadap Fibrosis yang Dipicu oleh TGF-B pada Rhinosinusitis Kronik tanpa Polip Hidung / Chronic Rhinosinusitis Without Nasal Polyps. (CRSsNP): Systematic Review Iwan Setiawan Adji; Nabila Putri Hartia; Yesa Nor Fatimah; Fidzol Birru ’Izza; Fany Raihan Padilah; Tiar Aqda Saputra
Jurnal Ventilator Vol. 4 No. 2 (2026): Juni : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v4i2.2539

Abstract

Chronic rhinosinusitis without nasal polyps is a chronic inflammatory disorder of the nasal and paranasal sinus mucosa characterized by persistent inflammation and structural tissue remodeling, including mucosal fibrosis. The transforming growth factor-beta signaling pathway plays an important role in fibrogenesis by promoting fibroblast activation, collagen synthesis, and extracellular matrix deposition. Channa striata contains various bioactive compounds with potential anti-inflammatory, antioxidant, and immunomodulatory effects that may contribute to tissue repair and regulation of fibrotic processes. This systematic review aimed to examine the potential role of Channa striata in TGF beta mediated fibrosis in based on available scientific evidence. The review was conducted according to the PRISMA guidelines and the PICO framework. Literature searches were performed in PubMed, ScienceDirect, Wiley Online Library, and Google Scholar for studies published between 2015 and 2026. After identification, screening, and eligibility assessment, 14 articles met the inclusion criteria and were analyzed. The findings indicate that activation of the TGF beta/Smad signaling pathway contributes to mucosal fibrosis through increased fibroblast proliferation, collagen production, and extracellular matrix remodeling. Evidence also suggests that Channa striata may modulate inflammatory mediators and growth factors involved in fibrogenesis. Therefore, Channa striata has potential as an adjuvant therapeutic candidate to reduce chronic inflammation and mucosal fibrosis in. However, direct clinical evidence in patients remains limited, and further studies are needed to confirm its efficacy, safety, and clinical applicability.
Epistaxis with Microcytic Hypochromic Anemia in Third-Trimester Primigravida: An ENT Diagnostic Challenge Iwan Setiawan Adji; Nabila Putri Hartia; Yesa Nor Fatimah; Fidzol Birru Izza; Fany Raihan Padilah; Tiar Agda Saputra
Jurnal Ilmu Kesehatan dan Gizi Vol. 4 No. 4 (2026): Oktober: Jurnal Ilmu Kesehatan dan Gizi
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jig.v4i4.9885

Abstract

Background: Epistaxis during pregnancy is usually associated with hormonal and vascular alterations of the nasal mucosa, but persistent or severe bleeding may result in substantial blood loss and aggravate anemia, particularly in patients with recurrent episodes. Case Report: A 33-week primigravida (G1P0A0) presented with recurrent epistaxis accompanied by oral blood expectoration. She had experienced recurrent epistaxis since childhood, chronic anemia, and previous blood transfusions. Laboratory evaluation showed severe microcytic hypochromic anemia (hemoglobin 7.9 g/dL, MCV 74.2 fL, MCH 21.7 pg, MCHC 29.3%) with a normal platelet count. Treatment included transfusion of three units of packed red blood cells and conservative therapy.  Discussion: Pregnancy-related vascular changes likely exacerbated chronic bleeding, causing secondary iron deficiency anemia. Differential diagnoses included rhinitis gravidarum, coagulation disorders, hereditary hemorrhagic telangiectasia, and thalassemia. Conclusion: Epistaxis during pregnancy may indicate conditions beyond physiological gestational changes. A multidisciplinary approach is essential to establish the underlying diagnosis and prevent maternal and fetal complications.
Co-Authors Fidzol Birru Izza Fidzol Birru ’Izza Iwan Setiawan Adji Iwan Setiawan Adji Nabila Putri Hartia Tiar Agda Saputra Tiar Aqda Saputra Yesa Nor Fatimah