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All Journal Jurnal Ilmiah Kesehatan Masyarakat Jurnal Sains dan Kesehatan
Iwan Setiawan Adji
RSUD Kartini Karanganyar
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Perbandingan Efektivitas Diazepam dan Magnesium Sulfat dalam Penanganan Kejang pada Tetanus: Tinjauan Literatur Iwan Setiawan Adji; Lina Nur Fatimah; Dhia Laila Nadzifa; Witrishya Anggrahini; Noval Gentha Mahensa
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 4 No. 4 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v4i4.6414

Abstract

Seizures are a serious complication of tetanus, contributing to high morbidity and mortality rates. Various therapeutic approaches have been employed to manage seizures, including diazepam and magnesium sulfate. This literature review aims to compare the effectiveness of these two agents in reducing both the frequency and severity of seizures in tetanus patients. A systematic search was conducted using scientific publications from PubMed, Google Scholar, and ScienceDirect over the past ten years. The review indicates that magnesium sulfate shows potential as an effective and relatively safe alternative to diazepam in certain clinical settings. However, variations in study design and limited available data highlight the need for further clinical trials to strengthen existing evidence. This review is expected to serve as a reference for clinicians in selecting optimal anticonvulsant therapy for tetanus cases. Furthermore, the study emphasizes the importance of understanding the pharmacological mechanisms, clinical indications, and monitoring of adverse effects to ensure both safety and efficacy of the therapy. Overall, this literature review contributes to the development of evidence-based clinical guidelines for managing seizures in tetanus patients.
Etiologi Multifaktorial dan Tantangan Diagnostik Disfagia pada Pasien Geriatri Usia Sangat Lanjut : Laporan Kasus dan Tinjauan Skoping Iwan Setiawan Adji; Zahira Husna Aflaha Khansa Siswaya; Hanif Nur Khairuddin; Eillena Noxie Azzahra; Namira Aisya Devi; Sultan Bayu Fahmi
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1172

Abstract

Dysphagia in extremely elderly patients represents a significant clinical challenge because it is frequently associated with frailty, malnutrition, and an increased risk of aspiration. Multifactorial etiologies and atypical clinical manifestations may complicate diagnosis and delay appropriate management. This study aimed to describe the diagnostic evaluation and clinical findings of dysphagia in an extremely elderly patient through a case report supported by a scoping review. A 105-year-old woman with chronic progressive dysphagia underwent comprehensive assessment, including physical examination, upper gastrointestinal endoscopy, histopathological evaluation, and chest radiography. Relevant literature on dysphagia in geriatric populations was reviewed to provide contextual understanding of diagnostic challenges and underlying etiologies. The evaluation revealed chronic active gastritis and a hamartomatous polyp in the gastroesophageal region without evidence of malignancy. Comprehensive assessment successfully excluded malignant and acute obstructive causes, emphasizing the complexity of dysphagia diagnosis in extremely elderly individuals with frailty and aspiration risk. These findings underscore the importance of endoscopic and histopathological examinations in distinguishing benign from malignant etiologies and support early recognition of multifactorial non-malignant causes to optimize clinical management and reduce the risk of adverse outcomes in this vulnerable population
Co-Authors Dhia Laila Nadzifa Eillena Noxie Azzahra Hanif Nur Khairuddin Lina Nur Fatimah Namira Aisya Devi Noval Gentha Mahensa Sultan Bayu Fahmi Witrishya Anggrahini Zahira Husna Aflaha Khansa Siswaya