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All Journal Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Heldi Candra
RSUD Embung Fatimah
Health Professions Nursing Public Health

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Association of Polypharmacy and Drug-Related Problems with Quality of Life in Hypertensive Patients with Comorbidities Kartini Hasballah; Zaki Mubarak; Heldi Candra; Fifin Oktaviani
Jurnal Ventilator Vol. 3 No. 2 (2025): Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v3i2.2811

Abstract

Hypertension frequently coexists with comorbidities such as type 2 diabetes, dyslipidaemia, and chronic kidney disease. That mix produces polypharmacy and raises the risk of drug-related problems (DRPs), which in turn can erode quality of life (QoL). This study set out to examine the relationship between polypharmacy, DRPs, and QoL in hypertensive patients with comorbidities. An observational cross-sectional study was carried out at the outpatient internal medicine clinic of X Hospital, Batam, from January to June 2024. Consecutive sampling yielded 130 patients meeting the inclusion criteria. Polypharmacy was defined as the concurrent use of five or more medications. DRPs were classified with the Pharmaceutical Care Network Europe (PCNE) V9.1 tool, Bahasa Indonesia version. QoL was measured using the validated Indonesian SF-36 questionnaire. Data were analysed with Spearman rank correlation and multivariate logistic regression. Polypharmacy was present in 63.1% of patients, and DRPs were identified in 76.2%, most commonly drug interactions (31.4%) and dose-selection issues (24.8%). Polypharmacy correlated negatively with total QoL scores (r = -0.542; p < 0.001), as did DRPs (r = -0.418; p < 0.001). Multivariate analysis confirmed polypharmacy (AOR 3.24; 95% CI 1.62-6.48) and DRPs (AOR 2.87; 95% CI 1.41-5.85) as independent predictors of poor QoL. Integrated pharmaceutical care with an explicit focus on medication review is critical for mitigating DRPs and improving QoL in this population.
Co-Authors Fifin Oktaviani Kartini Hasballah Zaki Mubarak