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All Journal Jurnal Ilmiah Farmasi
Prasilya, Sindi
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Medicine & Pharmacology

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Innovation of microemulsion of mangosteen fruit rind extract (Garcinia mangostana L.) as an antidiabetic agent for nephropathy Mahmudah, Rifa’atul; Salsahbila; Prasilya, Sindi; Amelia, Resty; Rahayu, Maghfira Dwi; Rasyid, Fitriani
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art20

Abstract

Background: Diabetes mellitus (DM) is a global health concern with a rising prevalence. Chronic kidney disease (CKD), affecting up to 40% of DM patients, is a severe complication. Mangosteen rind extract (MRE), containing bioactive compounds such as xanthone and α-mangostin, exhibits antidiabetic and nephroprotective potential, enhanced through microemulsion formulations that improve solubility, stability, and bioavailability.Objective: To evaluate the effectiveness of microemulsions containing MRE as antidiabetic and nephroprotective agents.Method: Microemulsion formulations were evaluated for organoleptic properties, pH, viscosity, homogeneity, and particle size. Effectiveness testing was conducted on male Wistar rats divided into five groups: a negative control, a positive control, and three treatment groups receiving MRE doses of 25, 50, and 100 mg/kgBW. Blood glucose levels and nephroprotective parameters were analyzed using one-way ANOVA and LSD post hoc tests (p>0.05).Results: The microemulsion met physical criteria, including optimal pH, stable viscosity, good homogeneity, and appropriate particle size. MRE significantly reduced blood glucose levels and improved kidney function, with the 100 mg/kgBW dose being most effective.Conclusion: MRE microemulsions are effective in lowering blood glucose levels and providing nephroprotective benefits, offering potential therapy for DM and diabetic nephropathy.
Co-Authors Amelia, Resty Mahmudah, Rifa’atul Rahayu, Maghfira Dwi Rasyid, Fitriani Salsahbila