Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan
Maya Indah Triwardani
Universitas Diponegoro
Health Professions Nursing Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
The Effects of Diabetes Mellitus on Bone Healing : A Systematic Review of RANKL and OPG Maya Indah Triwardani; Endang Mahati; Yuriz Bakhtiar
Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Vol. 4 No. 3 (2026): September: Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebida
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/corona.v4i3.2403

Abstract

Background: Diabetes mellitus (DM) impairs fracture healing by promoting advanced glycation end products, oxidative stress, and an imbalance in the RANKL/osteoprotegerin (OPG) system, thereby increasing bone resorption and inhibiting osteoblast activity. Objective: To evaluate the effects of DM on fracture healing as reflected by RANKL and OPG levels. Methods: This systematic review followed PRISMA and Synthesis without Meta-analysis (SWiM) guidance. PubMed, Scopus, and Google Scholar were searched for English-language studies published from January 2021 through May 2026. Eligible in vivo studies compared diabetic and non-diabetic rat fracture models and reported RANKL and/or OPG outcomes. Study selection, data extraction, and risk-of-bias assessment were conducted independently using the SYRCLE tool for animal studies. Results: Three studies met the inclusion criteria. Diabetic groups consistently showed higher RANKL and lower OPG than non-diabetic controls, indicating a higher RANKL/OPG ratio and a shift toward osteoclast-mediated bone resorption. These changes were accompanied by impaired bone formation and delayed healing-related outcomes. Conclusion: DM is associated with a consistent pro-resorptive imbalance in the RANKL/OPG system during fracture healing. The concordance across animal studies supports this pathway as a potential therapeutic target, while standardized studies and clinical validation remain necessary.
Co-Authors Endang Mahati Yuriz Bakhtiar