<![CDATA[ Occupational fatigue is a major issue that can reduce productivity, increase the risk of work-related errors, and compromise worker safety. Employees at the Nutrition Fulfillment Service Unit (SPPG) perform physically demanding tasks and are therefore at risk of experiencing work fatigue. This study aimed to analyze the relationship between nutritional status and physical workload with the level of work fatigue among workers at SPPG Kalibuntu, Brebes Regency. This research employed a quantitative cross-sectional design. A total of 50 workers were selected using the total sampling technique. Nutritional status was assessed using Body Mass Index (BMI), physical workload was measured using the Cardiovascular Load (CVL) method based on heart rate, and work fatigue was evaluated using the Industrial Fatigue Research Committee (IFRC) questionnaire. Data were analyzed using univariate and bivariate analyses with the Chi-Square test at a 95% confidence level. The results showed that most respondents were female (66%) and aged ≥40 years (56%). There was a significant relationship between nutritional status and work fatigue (p = 0,039), as well as between physical workload and work fatigue (p = 0,032). These findings indicate that nutritional status and physical workload are important factors associated with occupational fatigue. Therefore, appropriate workload management, adequate rest periods, and improved nutritional status are essential to reduce fatigue and enhance workers' productivity and occupational safety.]]>
