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All Journal Majalah Obstetri dan Ginekologi INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL
Andra Kusuma Putra
Department Obstetrics And Gynecology, Faculty Of Medicine, Universitas Hang Tuah, Surabaya, Jawa Timur, Indonesia.
Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Cleaved caspase-3 sebagai Uji Apoptosis pada Kanker Serviks IIB Tipe Sel Skuamosa yang Mendapat Kemoterapi Neoadjuvan Cisplatin Andra Kusuma Putra; Brahmana Askandar; Sjahjenny Mustokoweni
Majalah Obstetri dan Ginekologi Vol. 23 No. 1 (2015): Januari - April 2015
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.878 KB) | DOI: 10.20473/mog.V23I12015.22-27

Abstract

Tujuan: mencari peningkatan ekspresi cleaved caspase-3 pada pasien kanker serviks IIB tipe sel skuamosa sesudah pemberian kemoterapi neoadjuvan cisplatin dan mencari kapan waktu yang tepat untuk mendeteksi apoptosis menggunakan cleaved caspase-3. Bahan dan Metode: Jenis penelitian analitik observasional berpasangan. Dilakukan pada penderita kanker serviks IIB tipe sel skuamosa berdasarkan kriteria FIGO yang berobat di POSA RSUD Dr. Soetomo Surabaya. Penelitian dilakukan mulai bulan Mei 2014. Sebelum dilakukan terapi semua penderita diambil biopsi serviks. Kemudian penderita diberikan cisplatin 50mg/m2/minggu Diambil biopsi serviks setelah diberikan kemoterapi ke 1 dan ke 4 (maksimal 8 jam setelah kemoterapi, sampel kedua). Sampel diperiksakan imunohistokimia cleaved caspase 3. Dilakukan penghitungan ekspresi cleaved caspase 3 di bawah mikroskop dengan perbesaran 400x pada 10 lapang pandang. Pengujian statistik dilakukan dengan nilai kemaknaan p<0,05.Hasil: Rata-rata ekspresi cleaved caspase 3 sebelum kemoterapi adalah 1,46± 1,854. Setelah kemoterapi ke 1 didapatkan rata- rata 10,77± 3,655.Setelah kemoterapi ke 4 didapatkan rata- rata 12,77± 5,703. Pada pemeriksaan didapatkan ekspresi cleaved caspase 3 setelah pemberian kemoterapi lebih meningkat dibandingkan sebelum pemberian kemoterapi (p<0,01), sedangkan ekspresi cleaved caspase 3 setelah kemoterapi ke 1 dan ke 4 tidak didapat-kan perbedaan bermakna (p=0,882).Simpulan: Pemberian kemoterapi terbukti memberikan efek peningkatan ekspresi cleaved caspase-3. Sehingga cleaved caaspase-3 dapat dijadikan sebagai salah satu uji apoptosis pada efek kemoterapi terhadap sel kanker.
DIAGNOSTIC VALUE OF THE HYPERTENSIVE DISORDERS IN PREGNANCY GESTOSIS SCORE (HDP-GESTOSIS SCORE) IN PREDICTING PREECLAMPSIA AMONG PREGNANT WOMEN AT A TERTIARY HOSPITAL Syahda Latifatul Quriah; Verna Biutifasari; Andra Kusuma Putra; Moh Samsudin
Indonesian Midwifery and Health Sciences Journal Vol. 10 No. 3 (2026): Indonesian Midwifery and Health Sciences Journal, July 2026
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v10i3.2026.253-263

Abstract

Background: Globally, preeclampsia remains on of the leading causes of maternal and neonatal morbidity and mortality. Early identification of pregnancies at risk is essential to reduce adverse maternal and fetal outcomes. The HDP-Gestosis Score was designed as a simple screening approach for gestational hypertensive conditions, relying on basic clinical indicators that are easy to assess. The HDP-Gestosis Score is most valuable as a screening and risk-stratification tool. Its greatest benefit lies in identifying women who require enhanced monitoring and preventive management before the onset of overt hypertensive disease. bjective: The predictive performance of this clinical scoring approach was assessed among pregnant women receiving obstetric care at a tertiary referral hospital, during 2023-2024. Methods: A retrospective cross-sectional study using total sampling analyzed 230 medical records from a tertiary referral hospital during 2023-2024. Diagnostic performance was assessed using ROC analysis and logistic regression. Results: An HDP–Gestosis Score of ≥3 provided optimal discrimination (AUC = 0.936), with 100% sensitivity, 94.9% specificity, PPV of 90.1%, NPV of 100%, and 96.5% accuracy. Logistic regression confirmed a strong and significant association with preeclampsia (OR = 11.31; p < 0.001). Conclusion: This screening method demonstrates encouraging potential for early detection of preeclampsia; however, confirmation through large-scale prospective multicenter research remains essential.
Co-Authors Askandar Tjokroprawiro Moh Samsudin Sjahjenny Mustokoweni, Sjahjenny Syahda Latifatul Quriah Verna Biutifasari