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Extended Spectrum Beta-Lactamase ( ESBL ) Biutifasari, Verna
Oceana Biomedicina Journal Vol 1, No 1 (2018): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Antibiotika telah banyak digunakan sekarang ini. Pemakaian antibiotika yang berlebihan dan tidak sesuai dengan klinis dapat menyebabkan terjadinya resistensi terhadap antibiotika tersebutSalah satu antibiotika yang dipakai adalah antibiotika golongan beta-lactam yang bekerja menghambat dinding sel. Pemakaian antibiotika beta-lactam yang tidak sesuai dapat menyebabkan terjadi resistensi terhadap antibiotika tersebut. Resistensi terhadap beta-lactam dapar terjadi di berbagai tingkatan. Salah satu resistensi dapat terjadi adalah resistensi terhadap extendedspectrum broad lactamase (ESBL)Extended spectrum beta-lactamase adalah enzim yang mempunyai kemampuan dalam menghidrolisis antibiotika golongan penicillin, cephalosporin generasi satu, dua, dan tiga serta golongan monobactam dan menyebabkan resistensi ke seluruh antibiotika tersebut.ESBL banyak dihasilkan oleh Enterobactericeae (terutama Escherichia coli) dan Klebsiella pneumoniae. Enterobacteriaceae mempunyai 3 pola resistensi yang disebabkan broad spectrum beta-lactamase,inhibitor resistant beta-lactamase (derivat TEM) , Cephalosporinase yang berlebihan. ESBL dapat sulit terdeteksi karena ESBL mempunyai perbedaan tingkatan aktifitas terhadap bermacam-macam cephalosporinESBL dapat dideteksi secara clinical microbiology (phenotypic) dan molecular detection (genotypic). Keywords: Antiobiotika, resistensi, ESBL

Extended Spectrum Beta-Lactamase (ESBL) Verna Biutifasari
Denta Journal Kedokteran Gigi Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018
Publisher : Universitas Hang Tuah

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Antibiotics have been widely used today. Use of antibiotics is also often used in mass and not in accordance with the indication, among others, in a particular case of fish poisoning on the beach, often the treatment is given antibiotics without clearlyindication. Use of antibiotics are excessive and not in accordance with the clinical, can cause resistance to these antibioticsOne of the antibiotics used is a beta-lactam antibiotic, that works inhibits cell walls. The inappropriate use of beta-lactam antibiotics can lead to resistance to these antibiotics. Resistance to beta-lactam can occur at various levels. One of the resistances can occur is resistance to Extended Spectrum Broad Lactamase (ESBL)Extended spectrum beta-lactamase is an enzyme that has the ability to hydrolyze penicillin-type antibiotics, first-generation cephalosporins, two, and three as well as monobactam groups and cause resistance throughout the antibiotic.ESBL is produced by many Enterobactericeae (especially Escherichia coli) and Klebsiella pneumoniae. Enterobacteriaceae has 3 resistance patterns caused by broadspectrum beta-lactamase, beta-lactamase-resistant inhibitors (TEM derivatives), excessive cephalosporinase. ESBL can be difficult to detect because ESBL has differentiatedactivity to various cephalosporinsESBL can be detected in clinical microbiology (phenotypic) and molecular detection (genotypic)

Pengaruh Pencemaran Logam Berat Timbal (Pb) dan Ekskresi Iodium Urine (EIU) Terhadap Kejadian Stunting Pada Anak di Surabaya LEONI; WIENTA DIARSVITRI; VERNA BIUTIFASARI
HANG TUAH MEDICAL JOURNAL Vol 18 No 2 (2021): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background : The existence of children, living in the coastal area with such risk of suffering from lead (Pb) intoxication, is still considered high. This pollutant plays a role in children’s growth and development. Lead (Pb), existing in our body, would directly reduce the amount of iodine that is absorbed by our body and in the end, would reduce the number of hormones affecting both physical growth and mental development for instance Growth Hormone, Thyroid Hormone, and Insulin-like Growth Factor (IGF-1). Other than Lead (Pb), growth is affected by another factor such as heredity, nutrition, and physical activity. This study serves the purpose of determining the effect of lead (Pb) pollution and Urinary Iodine Concentration (UIC) on the occurrence of stunting in children at the age of 25-60 months old at the urban village of Kedung Cowek Surabaya. Methods : observational analytic study a cross-sectional study design, by using a quantitative method which was used on 27 mothers whose children are 25-60 months old at Posyandu RW 2 and RW 3 urban village of Kedung Cowek Surabaya. The sample was chosen using a purposive sampling method. Data was collected through weight and height measurement, age, KMS (Card Towards Health), KIA (Kartu Ibu dan Anak), and questionnaires done by interviewing. Bivariate analysis was performed using Kruskal-Wallis. Results : Based on the laboratory test, it is shown that there’s no lead (Pb) pollution detected in seawater with the final result of 0,00035 mg/L (polluted > 0,008 mg/L). Based on Kruskal-Wallis, Urinary Iodine Concentration (UIC) doesn’t influence the occurrence of stunting based on deviation standard and nutritional status from the Ministry of Health (p = 0,409). Conclusion : There is no effect of lead (Pb) pollution and Urinary Iodine Concentration (UIC) on the occurrence of stunting in children at the age of 25-60 months old at the urban village of Kedung Cowek Surabaya.

Extended Spectrum Beta-Lactamase (ESBL) Verna Biutifasari
Oceana Biomedicina Journal Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v1i1.3

Antibiotics have been widely used today. Use of antibiotics is also often used in mass and not in accordance with the indication, among others, in a particular case of fish poisoning on the beach, often the treatment is given antibiotics without clearlyindication. Use of antibiotics are excessive and not in accordance with the clinical, can cause resistance to these antibioticsOne of the antibiotics used is a beta-lactam antibiotic, that works inhibits cell walls. The inappropriate use of beta-lactam antibiotics can lead to resistance to these antibiotics. Resistance to beta-lactam can occur at various levels. One of the resistances can occur is resistance to Extended Spectrum Broad Lactamase (ESBL)Extended spectrum beta-lactamase is an enzyme that has the ability to hydrolyze penicillin-type antibiotics, first-generation cephalosporins, two, and three as well as monobactam groups and cause resistance throughout the antibiotic.ESBL is produced by many Enterobactericeae (especially Escherichia coli) and Klebsiella pneumoniae. Enterobacteriaceae has 3 resistance patterns caused by broadspectrum beta-lactamase, beta-lactamase-resistant inhibitors (TEM derivatives), excessive cephalosporinase. ESBL can be difficult to detect because ESBL has differentiatedactivity to various cephalosporinsESBL can be detected in clinical microbiology (phenotypic) and molecular detection (genotypic)

The Hygiene Hypothesis And Covid-19: A Look At The Evidence And New Perspectives Peppy Nawangsasi; Ronald Pratama Adiwinoto; Verna Biutifasari; Tamam Jauhar; Wahyu Prasasti Mutiadesi
ANATOMICA MEDICAL JOURNAL | AMJ Vol 6, No 3 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v6i3.15787

The hygiene hypothesis postulates that early-life exposure to infectious agents and microbes has a significant impact on the maturation of the immune system, providing protection against allergies and autoimmune diseases.Recent studies have challenged the hypothesis's universality, suggesting that it might only be relevant in developed countries. New perspectives on the hygiene hypothesis propose a multifaceted theory that considers not only microbial exposure but also factors such as diet, stress, and the environment. The role of specific immune cells in the development of allergies and autoimmune diseases has been emphasized, and innovative therapies based on manipulation of immune cells have been proposed. The importance of reconciling the hygiene hypothesis with recent insights into the human microbiome and the importance of maintaining a balance between hygiene and microbial exposure is also emphasized. Lastly, the article delves into the hygiene hypothesis, investigates the connection between gut microbiota dysbiosis and the development of allergies and autoimmune diseases, and examines the influence of COVID-19 on both gut microbiota and immune function.Keywords: allergies and autoimmune diseases, gut microbiome dysbiosis

Heat Shock Protein (HSP) 70 dalam apoptosis dan inflamasi Verna Biutifasari
Surabaya Biomedical Journal Vol 1 No 3 (2022): Mei
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i3.35

Semua organisme menunjukkan respon homeostasis ketika organisme tersebut mengalami perubahan yang cepat dalam lingkungannya. Kemampuan organisme untuk beradaptasi atau menyesuaikan diri dengan lingkungan barunya sangat penting untuk kelangsungan hidup, dan kemungkinan merupakan kekuatan pendorong integral dalam evolusi. Heat shock protein (Hsp) adalah kelompok protein yang ekspresinya meningkat sebagai respons terhadap injuri. Hsp berfungsi sebagai molekul chaperone, degradasi protein, menghambat apoptosis. Peningkatan kadar Hsp terjadi setelah stres. Hsp mempunyai peran sentral dalam homeostasis seluler. Sistem penamaan atau nomenklatur Hsp berdasarkan berat molekulnya dan macam Hsp. Salah satu Hsp yang sering dipelajari adalah Hsp-70 Tujuan dari penulisan review ini adalah menjelaskan tentang Hsp serta peranan pada apoptosis dan inflamasi.

Pengaruh Terapi Oksigen Hiperbarik Terhadap Kadar Enzim Katalase Jaringan Otak Tikus Model Alkohol Kronis VIRA AULIA KUSUMA WARDANI; NI KOMANG SRI DEWI UNTARI; KETUT EDY SUDIARTA; VERNA BIUTIFASARI
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.362

Latar belakang: Penyalahgunaan alkohol merupakan salah satu permasalahan serius setelah penyalahgunaan zat dan obat terlarang. Sebanyak 3,3 juta orang meninggal di dunia akibat penggunaan alkohol pada tahun 2018 dan bertanggung jawab atas 5,1% beban penyakit global. Penyalahgunaan alkohol dapat meningkatkan produksi reactive oxygen species (ROS). ROS menimbulkan dampak negatif terhadap serebelum yang berakibat pada penurunan kadar enzim katalase. Winsgoal tidak hanya menyediakan kemudahan deposit qris, tetapi juga tersedia deposit idn slot pulsa tanpa potongan, e-wallet dan transfer bank yang tidak kalah menarik. Terapi oksigen hiperbarik (TOHB) dapat menurunkan produksi ROS dan berpengaruh terhadap kadar enzim katalase jaringan otak. Tujuan: Membuktikan pengaruh terapi oksigen hiperbarik terhadap kadar enzim katalase jaringan otak hewan coba model alkohol kronis Metode: Tikus putih galur wistar diinduksi dengan alkohol 20% 4,5ml/kgBB setiap hari selama 6 minggu untuk mendapatkan model alkohol kronis. Penelitian ini menggunakan tiga kelompok yaitu kelompok kontrol yang tidak diinduksi (K0), kelompok perlakuan yang diinduksi alkohol tanpa TOHB (K1), kelompok intervensi yang diinduksi alkohol dan TOHB (K2). Hasil: Pengukuran kadar katalase didapatkan rerata dan standar deviasi sebesar K0 (877,74 ± 69,54), K1 (617,8 ± 245,32), dan K2 (952,85 ± 47,40); Uji statistik MWU pada kadar katalase mengalami perbedaan yang signifikan di tiap kelompok (p < 0,05). Kesimpulan: Terapi oksigen hiperbarik terbukti berpengaruh terhadap kadar enzim katalase pada hewan coba model alkohol kronis

Correlation Of Malnutrition Status With Malaria Incidents In Children Under 5 Years Old Pratama A., Ronald; Bimantara, Riza Fajar; Arundani, Prima; Biutifasari, Verna; Mertha Adnyana, I Made Dwi
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 4 No. 3 (2024): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v4i3.202

Malaria is a prevalent disease that continues to affect infants and results in the death of over 435,000 individuals worldwide, with children under the age of five accounting for 11-30% of these fatalities. Malnutrition afflicts millions of children worldwide, especially in Indonesia, and is the leading cause of mortality among toddlers. Investigate the correlation between malnutrition and the occurrence of malaria in children under the age of five. Additionally, explore the prevalence, factors that contribute to the risk, and underlying processes of both malaria and malnutrition. This study utilized 15 internationally recognized scholarly articles to investigate the correlation between malnutrition and the prevalence of malaria in children below the age of five. According to the analysis of 10 scholarly studies, the occurrence of malaria and malnutrition among children under the age of five remains significantly elevated, particularly in African nations, various countries in South Asia, Southeast Asia, the Middle East, Central America, and South America. The analysis of 3 journal papers examined the risk factors associated with malaria and malnutrition, specifically focusing on age, environment, sanitation, economy, education, food availability, and residing in refugee camps. After reviewing 9 journal publications, it has been shown that malnutrition is a risk factor for malaria. Additionally, one of the articles suggests that children who are malnourished have a reduced likelihood of contracting malaria. The findings of this scoping review indicate a bidirectional correlation between malnutrition and the occurrence of malaria in young children.

Pengaruh Myers Briggs Type Indicator (MBTI) Dengan Tingkat Stres Mahasiswa Kedokteran Sari, Arine Talitha; Nawangsasi, Peppy; Irawati, Ade; Biutifasari, Verna
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 5 No. 1 (2024): Juni
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

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Myers-Briggs Type Indicator (MBTI) is a tool to measure personality types whose results are presented through 4 dichotomies namely Extraversion/Introversion, Sensing/Intuition, Thinking/Feeling, and Judging/Perceiving. A person's personality type will affect the level of stress they feel. Stress is a condition when our body reacts due to a change in our environment, either physical or mental changes that cause us to feel disturbed. This study aims to determine the relationship between personality type based on Myers-Briggs Type Indicator (MBTI) with stress levels in medical students. This type of research is observational analytic. Respondents used were 62 people who were filled in by 2020 students at the Faculty of Medicine, Hang Tuah University and then analyzed using the Kendall Tau-b method. It was found that 15 respondents experienced mild stress, 39 respondents experienced moderate stress, and as many as 7 respondents experienced severe stress. 30 respondents of extroverted personality, 31 respondents of introverted personality, 43 respondents of sensing personality, 18 respondents of intuition personality, 28 respondents of thinking personality, 33 respondents of feeling personality, 52 respondents of judging personality and there are 9 respondents with perceiving personality type. The significance value between personality type and stress level exceeds the α value (α = 0.05) which means that there is no relationship between personality type and stress level

Systemic Immune-Inflammation Index (SII) and NeutrophilLymphocyte Ratio (NLR) as a Promising Predictor for Advanced Stage Events during the Follow-Up Period in Hepato-Gastrointestinal Cancer Patients Zenjaya, Kellyn Trycia; Biutifasari, Verna; Yudadi, Redemptus; Wibowo, Prajogo
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1186

Background: Tumor microenvironment has shown the role of inflammation in its progressivity. The heterogeneity of prognosis at the same TNM stage makes it difficult to classify patients who are more at risk of developing advanced stages. This study aimed to provide a deeper insight into the potential of cheap inflammation markers based on the Systemic ImmuneInflammation Index (SII) and Neutrophil-Lymphocyte Ratio (NLR) to predict the advanced stage during the follow-up period in patients with hepato-gastrointestinal cancer.Methods: Case-control research was conducted using 120 data of patients with hepatogastrointestinal cancer (Colorectal cancer (CRC), hepatocellular carcinoma (HCC), gastrointestinal stromal tumor (GIST), esophageal adenocarcinoma (EAC), pancreatic ductal adenocarcinoma (PDAC), cholangio carcinoma (CCA)) taken from patient medical records. The patients were divided into case and control groups based on the presence of advanced stage events during the follow-up period that were further classified by the NLR and SII value. The advanced-stage events were analyzed and compared between the two groups using Chi-Square and logistic regression analysis to perceive the predictive value of each ratio. Results: Patients with advanced-stage hepato-gastrointestinal cancer had higher NLR and SII than patients without advanced stage (p 0.001). The group of patients with advanced stages had an average NLR of 18.45 and an SII of 6588.13. The group of patients without advanced stages had an average NLR of 5.12 and SII of 1545.01. The cut-off value was determined using the ROC curve, for NLR was 6.48 (92.5% sensitivity and 71.2% specificity), and for SII was 2264.24 (92.5% sensitivity and 76.2% specificity).Conclusions: NLR and SII are cheap markers and have considerable potential for predicting advanced stage during the follow-up period in patients with hepato-gastrointestinal cancer. SII is more accurate as a predictor than NLR. These tools can be very useful in identifying the high-risk patients among the same TNM stage.

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