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All Journal Jurnal Harpodon Borneo Indonesian Journal of Jamu Annales Bogorienses
Pangestuti, Ratih
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Medicine & Pharmacology

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POTENSI RUMPUT LAUT SEBAGAI BAHAN DASR KOSMESEUTIKAL Rahmadi, Puji; Pangestuti, Ratih; Salim, Gazali
Jurnal Harpodon Borneo Vol 4, No 1 (2011): Volume 4 No 1 April 2011
Publisher : Jurnal Harpodon Borneo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.315 KB) | DOI: 10.35334/harpodon.v4i1.66

Abstract

Nowadays we were facing to the global warming which is causing climate changes. Global warming also promote by environmental degradation. Increment of human population and development on industrial realm are the main cause of environmental degradation. Wetland is one of environmental bufferwhich could enhance the environmental stress. Doing the wetland restoration is an effort to enhance ecological degradation. In this paper were discusses about wetland definition, functions, wetland restoration, effect of restoration and also some study cases of wetland restoration published by some researcher. Tidal Wetland Restoration itself could be defined as an actions taken in a converted or degraded natural wetland that result in the reestablishment of ecological processes, functions, and biotic/abiotic linkages and lead to a persistent, resilient system integrated within its landscape (Lewis, 1989). It must expect restoration could bring the better effluence to the ecology, however some time it?s not just happen like ideally. Some of the restoration activity could promote and lead the ecological degradation in the neighbor habitat from which restoration activity was conducted. Therefore to enhance the sustainability, restoration and good management should be applied in order and in good monitoring.  Keywords :  wetland, ecological, restoration, sustainability.
Antioxidant Capacities of Holothuria Sea Cucumbers Murniasih, Tutik; Putra, Masteria Yunovilsa; Pangestuti, Ratih
Annales Bogorienses Vol. 19 No. 2 (2015): Annales Bogorienses
Publisher : BRIN

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Abstract

Sea cucumbers are a potential source of biologically active metabolites that are widely used for nutraceutical, pharmaceutical and cosmeceutical products. In this study we investigated the antioxidant activity of several extracts of sea cucumbers, those are Holothuria scabra, Holothuria atra, Holothuria leucospilota, and Holothuria excellens collected from Lombok Island. The selected sea cucumber was then separated to get the active fractions and identified for profiling the secondary metabolites. Phytochemical screening reveals the presence of flavonoid, terpenoids, phenol, saponin, alkaloid, anthraquinone, and glycoside in the extracts of Holothuria sea cucumbers. Radical scavenging effects on the DPPH (1,1-diphenyl-2-picryl-hydrazyl) model were evaluated. The previous work reported that the crude extract of H. atra showed the highest potential of antioxidant capacity. H. atra extract was separated by column chromatography on silica gel and eluted with a gradient system of increasing polarity. Fraction 7 of H. atra extract showed significantly inhibited radical scavenging activity (35.3487 %) at concentration 1 mg/ml. The result of Gas Chromatography-Mass Spectrometry analysis of H. atra fraction 2 showed that it has several active antioxidant compounds which are ethyl cetylate (3), hexadecyl-oxirane (5), 3-chloro-4-hydroxybenzoic acid (6), andoleyl alcohol, trifluoroacetate (9). Moreover, the active fraction 7 indicated several compounds, those are cycloicosane (17), pentadecyl trichloroacetate (18), 14b-pregnane (21) and cis-4-yano-2-(2-hydroxycyclohexyl) pyridine. However, these are preliminary findings and further studies are needed to be focus on the purifications of unknown compounds and formulation for nutraceuticals.
In Vitro and In Silico Evaluation of Pancreatic Lipase Inhibition by Avicennia marina and Bruguiera gymnorrhiza Fruit Flour Extracts Chairunnisa, Afra; Rahardian, Muhammad Ryan Radix; Pangestuti, Ratih; Franyoto, Yuvianti Dwi; Kusmita, Lia
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.483

Abstract

Indonesia is rich in mangrove species, including Avicennia marina (brayo) and Bruguiera gymnorrhiza (lindur), whose fruits contain bioactive metabolites with potential anti-obesity activity. This study evaluated pancreatic lipase inhibition by brayo and lindur fruit flour extracts (raw and boiled) using in vitro and in silico approaches. Extracts were prepared by remaceration with 70% ethanol. Lipase inhibition was measured using a multimode microplate reader, while metabolites were identified by LC-HRMS and evaluated by molecular docking. Raw brayo showed the highest inhibition (84.29 ± 4.24%), followed by boiled brayo (83.01 ± 4.59%), raw lindur (75.24 ± 3.02%), and boiled lindur (73.88 ± 4.00%). Docking indicated strong binding of luteolin (−8.23 kcal/mol), 9-oxo-10(E),12(E)-octadecadienoic acid (−6.75 kcal/mol), and methyl eleostearate (−6.59 kcal/mol) to pancreatic lipase. These findings support mangrove fruit flour as a natural source of lipase inhibitors for obesity management.
Co-Authors Chairunnisa, Afra Franyoto, Yuvianti Dwi Gazali Salim Lia Kusmita Putra, Masteria Yunovilsa Rahardian, Muhammad Ryan Radix Rahmadi, Puji Tutik Murniasih