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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Jurnal Farmasi dan Sains Indonesia (JFSI) Pharmaceutical Sciences and Research (PSR)
Putra, Masteria Yunovilsa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Screening of Antibacterial and Antioxidant Activity from the Soft Corals Sinularia sp. and Sarcophyton sp. Origin Palu Bay, Central Sulawesi, Indonesia Tanod, Wendy Alexander; Dewanto, Didit Kustantio; Ndobe, Samliok; Riyadi, Putut Har; Putra, Masteria Yunovilsa
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 14, No 2 (2019): August 2019
Publisher : Research and Development Center for Marine and Fisheries Product Processing and Biotechnol

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5379.021 KB) | DOI: 10.15578/squalen.v14i2.394

Abstract

This study aimed to evaluate the potential antibacterial and antioxidant activities of Sinulariasp. and Sarcophyton sp. from the Palu Bay, Central Sulawesi, Indonesia. Soft corals were identified as Sinulariasp. (SC1), Sinularia sp. (SC2), andSarcophytonsp. (SC3). Antibacterial activity was examined using agar diffusion well method. Antioxidant activity was measured by the DPPH radical scavenging method. The samples were macerated in MeOH: DCM. The crude extracts were partitioned with DCM, EtOAc, and BuOH. The crude extract of Sinulariasp. (SC2) showed a very strong antibacterial activity as it was able to inhibit the growth of Staphylococcus aureusand Escherichia coliup to 10 mg/mL. Sinularia sp. (SC1) crude extract showed strong activity againstS. aureus, whereas it showed moderate against E. coli.Sarcophyton sp. (SC3) crude extract showed moderate activity against S. aureus, whereas it showed weak against E. coli. The partition fractions of the three soft coral extracts had the potential to be a potent antioxidant agent.
Identification and Evaluation of Antibacterial Compounds from the Vibrio sp. associated with the Ascidian Pycnoclavella diminuta Dermawan, Abdurraafi’ Maududi; Julianti, Elin; Putra, Masteria Yunovilsa
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

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Abstract

This study aims to obtain secondary metabolites that have antibacterial activity from bacteria endophytic of ascidian Pycnoclavella diminuta collected from the coast of Bitung, North Sulawesi, Indonesia. The research was started with screening antibacterial activity of six bacteria isolated from P. diminuta. The active bacteria were selected for identification using standard biological molecular method and further fermentation to produce secondary metabolites. The isolation of secondary metabolites was conducted by various chromatography method and then selected fraction was based on the antibacterial activity from bioautography results. The result showed that the active isolate by coding M2.Tnk.Bt 5.10-3.2 was identified as Vibrio sp. The potential active fraction was further sub-fractionated by HPLC semi-preparative and each of these sub-fractions was tested against Staphylococcus aureus, Bacillus cereus, Enterococcus faecalis, Eschericia coli, and Vibrio cholerae. The test results showed that all 17 sub-fractions were active against Gram-positive bacteria S. aureus and B. cereus, and only one sub-fraction (SFr 2) showed antibacterial activity against E. faecalis. Whereas in Gram-negative bacteria, 2 sub-fractions (SFr 12 and SFr 13) showed antibacterial activity against E. coli and 12 sub-fractions active against V. cholerae. GC-MS analysis of the SFr 2 sub-fraction showed the presence of fifteen phytochemical constituents with a major compound Pyrrolo [1,2-a] pyrazine-1,4-dione, hexahydro-3- (2 methylpropyl).
Antimicrobial and Cytotoxic Properties of the Ascidians Lissoclinum patella, Oxycoryna fascicularis, Didemnum molle and Botryllus schlosseri Karim, Firmansyah; Putra, Masteria Yunovilsa; Hadi, Tri Aryono; Abrar, Muhammad
Pharmaceutical Sciences and Research Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

The aim of this research is to investigate antimicrobial and cytotoxic activity from Indonesian ascidians. Extracts prepared from the Indonesian ascidians Lissoclinum patella, Oxycoryna fascicularis, Didemnum molle and Botryllus schlosseri were assessed for anti-microbial and cytotoxic properties. Antibacterial activity of the extracts was tested against two Gram-positive bacteria, viz. Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923, and three Gram-negative bacteria, viz. Escherichia coli ATCC 25922, Vibrio cholerae ATCC 14035 and Pseudomonas aeruginosa ATCC 101454 using the disk diffusion test. Antifungal activity was also tested against Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404. The minimum inhibitory concentrations (MICs) of potential ascidian extracts were determined by the microdilution technique. Cytotoxicity of the extracts was assessed using the brine shrimp lethality bioassay. By comparing the inhibition zones in the disk diffusion test, the most active anti-bacterial activity against Gram-positive bacteria (S. aureus and B. subtilis) was found in the crude extracts of Oxycoryna fascicularis and Didemnum molle. Lissoclinum patella extract showed the highest activity against the Gram-negative bacteria E. coli and V. cholerae. The LC50 values of the crude extracts of Lissoclinum patella, Didemnum molle, Botryllus schlosseri, and Oxycoryna fascicularis were 74.3, 97.2, 114.7 and 132.9 μg/ml, respectively. In our study, the most promising species for anti-microbial and cytotoxic properties are Lissoclinum patella and Didemnum molle.
Chemical Composition, Antimicrobial, Cytotoxic and Antiplasmodial Activities of Three Sponges from Buton Islands, Indonesia Putra, Masteria Yunovilsa; Hadi, Tri Aryono
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 22, No 3 (2017): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (507.734 KB) | DOI: 10.14710/ik.ijms.22.3.147-154

Abstract

GC-MS analysis of the crude extracts of three different species of Indonesian marine sponges has been carried out for identification of bioactive compounds. The GC-MS analysis from Haliclona (Gellius) sp., Lamellodysidea herbacea, and Spheciospongia inconstans revealed the presence of 23, 21, 19 various compounds, respectively and mainly sterols and fatty acids. All the sponge species has been evaluated for antimicrobial activities, cytotoxicity using brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antiplasmodial activity. In this study, all the sponge species showed antimicrobial activities against at leastone of the test strains. Among them, the extract of sponge Lamellodysidea herbacea displayed activity against two Gram-positive bacteria (S. aureus and B. subtilis) and the Gram-negative bacteria V. cholerae, with inhibition zones of 10.3, 9.2 and 9.5 mm, respectively. The sponge Haliclona (Gellius) sp., showed significant activity against fungal pathogen C. albicans. The sponge Haliclona (Gellius) sp., displayed the ability to inhibit heme polymerization indicating an anti-Plasmodium function and also showed potent cytotoxic activity against the brine shrimp Artemia sp. Keywords: GC-MS analysis, antimicrobial, sponges,bioactive
Roselle and Red Ginger: A Potential Combination of Medicinal Plants for Hypertension Therapy Yunas, Ranum Wanudya; Rahmawati, Siti Irma; Saputri, Fadlina Chany; Bayu, Asep; Chianese, Giuseppina; Putra, Masteria Yunovilsa
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Hypertension is a prevalent cardiovascular condition that significantly increases the risk of heart disease and stroke. Effective management is essential to prevent severe complications. Roselle (Hibiscus sabdariffa L.) and red ginger (Zingiber officinale var. rubrum) are two medicinal plants known for their antihypertensive properties. Roselle contains bioactive compounds such as anthocyanins that exhibit vasodilatory and angiotensin-converting enzyme (ACE) inhibition, while red ginger is rich in gingerols and shogaols, which possess anti-inflammatory and vasodilatory properties. The complementary mechanisms of action of these two plants, including ACE inhibition, antioxidant activity, and modulation of vascular tone, result in a more pronounced antihypertensive effect when used together. By targeting multiple pathways, the combination allows for more effective blood pressure control, which could lead to improved patient outcomes. The purpose of this study is to provide a detailed review of the evidence supporting the use of roselle and red ginger in combination as a potential therapeutic approach for hypertension. This review aims to identify gaps in the existing research and suggest directions for future studies. Understanding the synergistic effects of these plants can help in developing more effective herbal therapies that leverage their combined benefits. Further research is needed to confirm these findings through more in-depth preclinical and clinical studies. Investigations should focus on optimizing dosages, understanding long-term safety, and establishing standardized protocols for combination therapy. This review serves as a foundation for future research and encourages the integration of traditional herbal medicine into modern hypertensive management strategies, promoting a holistic approach to cardiovascular health.
Studi In Silico dari Metabolit Invertebrata Laut Indonesia terhadap Protein ACE2 dan Spike Protein SARS-CoV-2 Varian Omicron Claus, Matheus Prayoga; Putra, Masteria Yunovilsa; Wibowo, Joko Tri; Yanuar, Arry
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p128-139

Abstract

Indonesia has a diverse marine biota with bioactive substances that may provide a way to overcome COVID-19. In this research, we explored secondary metabolites isolated from marine invertebrates in Indonesia. A total of 137 compounds from different types of invertebrates were screened against ACE2 and SARS-CoV-2 Omicron spike protein. In relation, molecular docking and ADMET prediction were investigated to find the best compound. A molecular dynamics study was performed to determine the stability of the binding between the compound and ACE2 and RBD of the Omicron spike protein virus receptor. The results showed that acanthomanzamine E and cortistatin L have prominent molecular docking properties as ACE2 and SARS-CoV-2 Omicron spike protein blockers with binding energies of -12.87 and -9.96 kcal, respectively. The ADMET results also showed that both compounds have a promising drug-likeness, with only minor exceptions in partition coefficient (logP) and half-life. In conclusion, acanthomanzamine E and cortistatin L have shown significant potential as lead compounds for drug targeting ACE2 and SARS-CoV-2 blockers.
Co-Authors Arry Yanuar Bayu, Asep Chianese, Giuseppina Claus, Matheus Prayoga Dermawan, Abdurraafi Maududi Dewanto, Didit Kustantio Fadlina Chany Saputri Joko Tri Wibowo, Joko Tri Julianti, Elin Karim, Firmansyah Muhammad Abrar Putut Har Riyadi Rahmawati, Siti Irma Samliok Ndobe Tri Aryono Hadi Wendy Alexander Tanod Yunas, Ranum Wanudya