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All Journal JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) JSFK (Jurnal Sains Farmasi & Klinis) JURNAL KESEHATAN PERINTIS Journal of Pharmaceutical and Health Research Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Ifmaily, Ifmaily
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Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Readiness Analysis of Hospital Management Information System Implementation using COBIT 5 Framework Transino, Talsi; Ifmaily, Ifmaily; Yetti, Husna
JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Vol 10, No 3 (2021): December
Publisher : Universitas Muhammadiyah Yogyakarta in Clollaboration with ADMMIRASI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jmmr.v10i3.12193

Abstract

Every hospital has to implement Hospital Management Information System (HMIS) based on Permenkes No. 82 Tahun 2013. Health care delivery can be more effective and efficient through HMIS implementation. RSUD Solok Selatan has planned to implement HMIS since 2019 until recently. The purpose of this study is to know the readiness of HMIS implementation in RSUD Solok Selatan using COBIT 5 Framework, specifically APO02 process (strategic management), APO07 (human resource management), and APO12 (risk management). This study was conducted with qualitative-quantitative approach. Qualitative data was collected with an interview. Meanwhile, quantitative data was collected with questionnaire according to COBIT 5 Framework. Respondents of this study was determined by RACI chart in COBIT 5. Capability level of APO02 achieved level 0, based on the level 1 assessment was 2,48 (not achieved). The capability level of APO07 was level 0 and level 1 assessment was 1,25 (partially achieved). Capability level of APO12 was level 0 and level 1 assessment was 1,0 (not achieved). Level 0 indicated that COBIT 5 was non implemented or the process fails to achieve its outcome. Readiness in strategic management, human resource management, and risk management was not optimally planned. RSUD Solok Selatan needs to increase its capability to plan HMIS implementation for better output.
Perbandingan Aktivitas Antioksidan Ekstrak Biji Mangga Arumanis (Mangifera indica L.) Segar dan Kering dengan Metode DPPH (1,1 Diphenyl-2-picrylhidrazyl) Ifmaily, Ifmaily; Juli Fendri, Sandra Tri; Husyalam, Mifta; Rahmawati, Annisa
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.4669

Abstract

In previous research, the arumanis mango plant was proven to have antioxidant properties, because it contains secondary metabolites of flavonoids and tannins. Based on this research, arumanis mango seeds also contain flavonoids and have the potential to act as antioxidants. Arumanis mango seeds are a form of organic waste that is often thrown away after we eat arumanis mango fruit and have the potential to be used as a basic ingredient for making antioxidant products. The aim of this research was to determine the antioxidant activity and compare the antioxidant of fresh and dried arumanis mango seed extract samples using the DPPH (1,1-diphenyl-2-picryhydrazyl) method. The results obtained from the maximum absorption wavelength of DPPH are 518 nm, with an absorbance of 0.647. The results of comparative antioxidant activity for gallic acid obtained IC50 = 2.8997 µg/mL, and a sample of fresh arumanis mango seed extract with an IC50 value = 20.4806 µg/mL, and dried mango seed extract IC50 = 21.1501 µg/mL. Based on the research results obtained, the antioxidant activity of fresh and dried arumanis mango seed extract samples was classified as very strong (<50 µg/mL). The antioxidant activity of fresh extracted seed samples was higher than that of dried arumanis mango seed samples, because if IC50 higher, its mean antioxidant activity is lower.
Uji Aktivitas Antihiperglikemia Ramuan Tradisional Pada Tikus Jantan yang Diinduksi Aloksan afrianti, Ria; Ifmaily, Ifmaily; Putri, Wika
JURNAL KESEHATAN PERINTIS Vol 11 No 1 (2024): Jurnal Kesehatan Perintis
Publisher : LPPM UNIVERSITAS PERINTIS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33653/jkp.v11i1.1026

Abstract

Tanaman bawang putih, jahe merah dan lemon merupakan tanaman yang digunakan sebagai obat tradisional, salah satunya sebagai obat diabetes melitus, dan juga cuka apel yang merupakan hasil fermentasi apel juga terbukti dapat menurunkan kadar gula darah. Penggunaan di masyarakat banyak menggunakan campuran bahan tersebut dalam bentuk ramuan yang sudah di olah sebagai pengobatan pada penyakit degenerative. Tujuan dari penelitian ini yaitu untuk menentukan pengaruh pemberian ramuan tradisional pada tikus yang diinduksi aloksan untuk mengetahui dosis efektif dari ramuan tradisional yang dapat menurunkan kadar glukosa darah pada tikus hiperglikemia. Jenis penelitian adalah eksperimental yang menggunakan tikus putih jantan sebagai hewan percobaan yang berjumlah 18 ekor, terbagi menjadi 6 kelompok yaitu kelompok kontrol negatif, kontrol positif, dan kelompok pemberian ramuan tradisional dengan volume 0,1 mL, 0,15 mL dan 0,2 mL dan kelompok pembanding (Glibenklamid). Pemberian larutan uji dilakukan selama 7 hari setelah di induksi dengan aloksan dan pengukuran dilakukan pada hari ke-3 dan ke-7 setelah pemberiaan sediaan uji. Hasil penelitian menunjukkan nilai persentase penurunan kadar glukosa darah kelompok 3 (83,33%), kelompok 4 (84,07%), kelompok 5 (86,04%) dan pembanding (glibenklamid) (90,10%). Ramuan tradisional terbukti dapat menurunkan kadar glukosa darah pada tikus jantan yang diinduksi aloksan berdasarkan hasil anova dua arah dimana p<0,05. Ramuan tradisional ini bersifat sebagai preventif dan pilihan obat alternatif dalam menurunkan kadar glukosa darah.
Cytotoxic Potential of Mangifera indica L var Arumanis Rind Extract and Fraction Against T47D Cells with Microtetrazolium (MTT) Method Ifmaily, Ifmaily; Oktafera, Oktafera
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6984

Abstract

Breast cancer is a major problem in the health sector, one type of malignant cancer in Indonesia and the world. Medical therapy for cancer patients has had side effects such as nausea, vomiting, weakness, diarrhea and hair loss. The arumanis mango rind, in previous research, contains secondary metabolites of flavonoids, phenolics, saponins and tannins. Arumanis mango rind extract has been studied to have antioxidant activity with an IC50 of 18.29 µg/ml and a toxic, toxicity test with an LC50 of 169.04 µg /ml. The aim of the research was to determine the cytotoxic potential of arumanis mango rind extract and fractions against T47D cancer cells using the Microtetrazolium (MTT) method from the percentage of cancer cell viability, IC50, and cancer cell morphology. It was using ethanol extract, n-hexane fraction, ethyl acetate fraction, and n-butanol fraction, with concentrations of 1000, 100, 10, 1, 0.1 μg/ml against T47D cancer cells. Data were the life cell absorbance obtained from the ELISA reader, to calculate the percentage of T47D cell viability, obtain IC50, then observe the morphology of the cancer cells. The results of the percentages of cell viability ( μg/ml ) from the ethanol extract were 81.1: 103.5; 137.3; 163; 165.5, n-hexane fraction were 28.5; 82.7; 105.1; 130.5; 132.5, ethyl acetate fraction were 15.9; 27.2; 101.7; 134.1; 162.7, n-butanol fraction were 32.6; 75.6; 82.8; 122.3; 146.4, doxorubicin as a comparison were 22.6; 38.4; 45.4; 53.4; 56. The IC50 results of the ethanol extract, the n-hexane fraction, the ethyl acetate fraction, the n-butanol fraction, and doxoburicin were 32.21; 616.59; 90.57; 338.84, and 1.44. The best of cancer cell morphology was doxorubicin, ethanol extract, and ethyl acetate fraction. The conclusion that the extract and fraction of arumanis mango rind had cytotoxic potential against T47D cancer cells from the percentages of cell viability, IC50 and cancer cell morphology, and the best of result are ethanol extract, ethyl acetat fraction, also doxorubicin as comparison drug.
The Effect of Arumanis Mango Rind (Mangifera indica L) Extract as Antidiabetic in Rats Model Ifmaily, Ifmaily; Firla, Afni; Fitriani, Putri Rizki
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.256-263.2023

Abstract

Arumanis  mango (Mangifera indica L) rind is one of the organic wastes containing flavonoid compounds. The objectives of this study were to find out the effect of arumanis mango rind extract on alloxan-induced blood glucose reduction in rats, to find out the most effective dose for reducing the levels of blood glucose in diabetic rats, and to find out the histopathology of the pancreas in diabetic rats.We used experimental method. In this study, 24 rats were divided into six groups consisting of I negative control, II positive control, III, IV, V different doses of 100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW and VI comparison group ( glibenclamide ). Groups II to VI were administered alloxan at 150 mg/kg BW for 3 days, and then the extract was administered to each group for 14 days, except group II. The levels of blood glucose were measured using a glucometer via the capillary of rat’s tail,  before and after induction and after administration of extract to all groups. The results are analyzed by the one-way ANOVA it showed significantly different results (p< 0.05 ). The extract of arumanis mango rind in all doses, had an effect on decreasing the level of blood glucose in diabetic rats effectively in dose of 400 mg/kg BW ( group V ) and histopathology desricptive results showed that arumanis mango rind extract could reduce damage to the pancreatic islet of Langerhans with histopathology of the exocrine glands and endocrine glands at group V was better than at group III and IV.
Pengaruh Ekstrak Kulit Buah Mangga Harum Manis (Mangifera indica L) terhadap Tekanan Darah pada Tikus Putih Jantan Hipertensi Ifmaily, Ifmaily
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 2 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i2.2240

Abstract

Hypertension is the most common disease in Indonesia. The impact of hypertension can affect other organs such as the kidneys, heart, and eventually cause death. The prevalence of hypertension increases from year to year. One alternative treatment for hypertension is the use of natural ingredients that contain flavonoids. Mango (the leaves, fruit, fruit peel and stems) is one of the plants that can be used for anti-hypertension, because of its flavonoid content. Ethanol extract of leaves, fruit and stem of Mango already proved as an antihypertensive drug, but the peel of the fruit has not been studied, so far it has only been a waste. The purpose of this study was to determine the effect of varying doses of the extract of mango peel varieties Harum Manis (EKBMHM) on white male hypertensive rats. This study was experimental with a pretest-posttest control group design, using male white rats, divided into 6 groups: negative control group, positive control, treatment group 30 mg / kg BW, treatment group 60 mg / kg BW, treatment group 120 mg / kg BW and comparison group (amlodipine 5 mg / kgBW. Prednisone 1.5 mg / kgBW in 2.5% NaCl are used to induce hypertension in animal. The parameters used were blood pressure which measured using a Non-Invasive Blood Pressure. Data analysis was calculated using one-way ANOVA followed by Duncan's test. The results obtained showed a dose of 30 mg / kg BW and a dose of 120 mg / kg BW extract of mango peel cannot reduce blood pressure, while a dose of 60 mg / kg BW can reduce blood pressure in hypertensive rats where the results of blood pressure measurements are not significantly different with comparison group (amlodipine 5 mg / kg BW). The conclusion for this research,the administration of mango peel varieties Harum Manis extract at a dose of 60 mg / kg BW given to hypertensive rats shows potential as an antihypertensive drug (p value = 0.047).
Co-Authors Annisa Rahmawati Firla, Afni Fitriani, Putri Rizki Husna Yetti Husyalam, Mifta Juli Fendri, Sandra Tri Oktafera, Oktafera Putri, Wika Ria Afrianti Transino, Talsi