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All Journal Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran
A. Askia Ihda Surur Akhiruddin
Universitas Muslim Indonesia
Health Professions Public Health

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Pengaruh Ekstrak Daun Balakacida (Chromolaena odorata) terhadap Jumlah Fibroblas pada Luka Pasca Pencabutan Tikus Wistar (Rattus norvegicus) Muhammad Fajrin Wijaya; Ardian Jayakusuma Amran; Sulfiana Sulfiana; Taufan Lauddin; A. Askia Ihda Surur Akhiruddin
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 3 No. 4 (2026): Oktober: Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v3i4.3517

Abstract

Dental and oral diseases remain a major health problem in Indonesia and frequently require tooth extraction procedures, which result in injury to the oral cavity tissues. The post-extraction wounds healing process involves several phases, including the proliferative phase, characterized by the critical role of fibroblast in new tissue formation. Wound healing can be hindered by various factors, therefore, agents capable of accelerating this process are needed. Balakacida leaf (Chromolaena odorata) are medicinal plants known to contain active compounds such as flavonoids, tannins, and saponins, which have the potential to accelerate wound healing. To determine the effect of Balakacida leaf extract (Chromolaena odorata) on fibroblast count in post-tooth extraction wounds of Wistar rats (Rattus norvegicus). This study uses an experimental method with a Post-Test Only Control Group Design. The research samples were male Wistar rats (Rattus norvegicus), aged 2–3 months, with body weights of 200–250 grams. The research data were processed and analyzed using the One-Way ANOVA test. There was no statistically significant difference in fibroblast counts between the control group and the treatment groups receiving Balakacida leaf extract at concentrations of 10%, 20%, and 30%. The administration of Balakacida leaf (Chromolaena odorata) extract at concentrations of 10%, 20%, and 30% is not yet effective in increasing the fibroblast count in post-tooth extraction wounds of Wistar rats.
Co-Authors Ardian Jayakusuma Amran Muhammad Fajrin Wijaya Sulfiana Sulfiana Taufan Lauddin