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All Journal Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Vitamin: Jurnal Ilmu Kesehatan Umum
Sulfiana Sulfiana
Universitas Muslim Indonesia
Health Professions Nursing Public Health

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Pengaruh Penggunaan Ekstrak Daun Balakacida (Chromolaena odorata) sebagai Agen Hemostatik Pasca Pencabutan pada Tikus Wistar (Rattus norvigicus) Muhammad Fajrin Wijaya; Ardian Jayakusuma Amran; Taufan Lauddin; Sulfiana Sulfiana; Nurul Annisa Syarifuddin
Vitamin : Jurnal ilmu Kesehatan Umum Vol. 4 No. 1 (2026): January : Jurnal ilmu Kesehatan Umum
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/vitamin.v4i1.2105

Abstract

Tooth extraction is a procedure to remove a tooth from its alveolar bone socket. The causes for tooth extraction include caries, periodontitis, fractures, impacted teeth, the need for orthodontic treatment, and persistent primary teeth. Post-extraction bleeding is the most common complication that occurs. Hemostasis is a mechanism to stop bleeding from blood vessels to prevent excessive blood loss when an injury occurs, ensuring that blood continues to flow smoothly. In stopping bleeding, there are three processes involved: vasoconstriction (the narrowing of blood vessels), platelet activity, and the activity of blood clotting factors. Bleeding time is the time interval from when blood exits the blood vessel until the bleeding stops. The normal range for bleeding time is 1 to 3 minutes. Balakacida leaves contain active compounds including alkaloids, tannins, flavonoids, saponins, and phenolics. To determine the effect of Balakacida leaf extract (Chromolaena odorata) as a hemostatic agent following tooth extraction in Wistar rats (Rattus norvegicus). This study uses an experimental method with a Post-Test Only Control Group Design. The samples used in this research are male Wistar rats (Rattus norvegicus), aged 2–3 months, weighing between 200–250 grams. The research data were processed and analyzed using the One-Way ANOVA test. The results showed that treatments at concentrations of 10%, 20%, and 30% were able to significantly accelerate bleeding time compared to the control group. The administration of Balakacida leaf extract is effective as a hemostatic agent following tooth extraction in Wistar rats.
Pengaruh Ekstrak Daun Balakacida (Chromolaena odorata) terhadap Jumlah Fibroblas pada Luka Pasca Pencabutan Tikus Wistar (Rattus norvegicus) Muhammad Fajrin Wijaya; Ardian Jayakusuma Amran; Sulfiana Sulfiana; Taufan Lauddin; A. Askia Ihda Surur Akhiruddin
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 3 No. 4 (2026): Oktober: Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v3i4.3517

Abstract

Dental and oral diseases remain a major health problem in Indonesia and frequently require tooth extraction procedures, which result in injury to the oral cavity tissues. The post-extraction wounds healing process involves several phases, including the proliferative phase, characterized by the critical role of fibroblast in new tissue formation. Wound healing can be hindered by various factors, therefore, agents capable of accelerating this process are needed. Balakacida leaf (Chromolaena odorata) are medicinal plants known to contain active compounds such as flavonoids, tannins, and saponins, which have the potential to accelerate wound healing. To determine the effect of Balakacida leaf extract (Chromolaena odorata) on fibroblast count in post-tooth extraction wounds of Wistar rats (Rattus norvegicus). This study uses an experimental method with a Post-Test Only Control Group Design. The research samples were male Wistar rats (Rattus norvegicus), aged 2–3 months, with body weights of 200–250 grams. The research data were processed and analyzed using the One-Way ANOVA test. There was no statistically significant difference in fibroblast counts between the control group and the treatment groups receiving Balakacida leaf extract at concentrations of 10%, 20%, and 30%. The administration of Balakacida leaf (Chromolaena odorata) extract at concentrations of 10%, 20%, and 30% is not yet effective in increasing the fibroblast count in post-tooth extraction wounds of Wistar rats.
Co-Authors A. Askia Ihda Surur Akhiruddin Ardian Jayakusuma Amran Muhammad Fajrin Wijaya Nurul Annisa Syarifuddin Taufan Lauddin