Wikanta, Edmond Rukmana
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Journal : Medica Hospitalia

PERBEDAAN RIWAYAT PENYAKIT TIROID TERDAHULU, METASTASIS DAN ABNORMALITAS PEMERIKSAAN ULTRASONOGRAFI ANTARA PASIEN KARSINOMA TIROID PAPILER KLASIK DAN VARIAN FOLIKULER DI RSUP Dr. KARIADI SEMARANG Firdauzi Putri, Nabila Zenska; Istiadi, Hermawan; Wikanta, Edmond Rukmana; Miranti, Ika Pawitra
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.451 KB) | DOI: 10.36408/mhjcm.v8i1.504

Abstract

Background: Papillary thyroid carcinoma (PTC) is the most common carcinoma, accounting for more than 90% of all malignancies, where the most variants are classic papillary thyroid carcinoma and follicular variant papillary thyroid carcinoma (PTCVF). The characteristics of previous thyroid disease history, regional metastases, and ultrasound examination results can influence the clinical examination between the two variants of PTC, namely classic PTC and PTCVF. Aim: Understanding the differences in the history of previous thyroid disease, metastases, and ultrasound examination abnormalities between Classical Papillary Carcinoma and Follicular variants at Dr. Kariadi Hospital, Semarang. Methods: A cross sectional study with consecutive sampling method in classic PTC and PTCVF patients in Dr. Kariadi Hospital, Semarang who was diagnosed in the period January to June 2019. In this study, the number of samples obtained was 18 medical records with classic PTC cases and 20 medical records with PTCVF cases. The dependent variables, namely history of previous thyroid disease, regional metastases, and ultrasound examination abnormalities, all of which were on an ordinal scale, were analyzed using non-parametric chi-square test and Fisher's Exact test. Results: In the non-parametric chi-square test and Fisher's Exact test, the results were not significant (p = 0.474), regional metastases were not significant (p = 0.359), ultrasound size abnormalities were not significant (p = 0.323), and abnormalities. ultrasound nodal was not significant (p = 0.595). Conclusion: There was no statistically significant difference in the history of previous thyroid disease, regional metastases, and ultrasound examination abnormalities between classic PTC and PTCVF patients at Dr. Kariadi Hospital, Semarang.
PERBEDAAN USIA, UKURAN MAKROSKOPIS TUMOR, DAN PROFIL HORMON ANTARA PASIEN KARSINOMA TIROID PAPILER KLASIK DAN VARIAN FOLIKULER DI RSUP DR KARIADI SEMARANG Nabila, Alin; Istiadi, Hermawan; Wikanta, Edmond Rukmana; Miranti, Ika Pawitra; Puspasari, Dik
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.183 KB) | DOI: 10.36408/mhjcm.v8i2.508

Abstract

Background: New cases of Papillary Thyroid Carcinoma and Carcinoma patients at Dr. Kariadi Hospital, Semarang is quite high, where the most types are Classical Papillary Thyroid Carcinoma and Follicular Variant Papillary Thyroid Carcinoma. On the other hand, in diagnosing PTC, histopathological examination which is a gold standard sometimes has a subjective value. Therefore, it is necessary to have a correlation with the clinical characteristics of the patient in order to get a correct diagnosis. Aim: Understanding the differences in age characteristics, tumor macroscopic size and hormone profile between Classical Papillary Thyroid Carcinoma and Follicular Variant patients at Dr. Kariadi Hospital, Semarang. Method: Analytic observational research with cross sectional design. The number of samples was 38 medical records in which 18 cases of Classic Papillary Thyroid Carcinoma and 20 cases of Follicular Variant Papillary Thyroid Carcinoma. Data with a nominal scale, namely age were analyzed using the Fisher exact test, while the data with a numerical scale, namely the macroscopic size of the tumor and the hormone profile, were tested for normality of Saphiro Wilk then continued with the Mann-Whitney test. Result: Based on the Fisher exact test, there was significant difference (p = 0,009) between age characteristics and Classical Papillary Thyroid Carcinoma and Follicular Variant. In the Mann-Whitney test there was no significant difference (p = 0.3) between the macroscopic size of the classical papillary carcinoma and follicular variant and there was no significant difference TSHs (p = 0.501) and fT4 (p = 0.953) hormone profiles between Classic Papillary Thyroid Carcinoma and Follicular Variants. Conclusion: There was significant difference between the characteristics of age at diagnosis, and there was no significant difference between the macroscopic size of the tumor and the hormonal profile of Classical Papillary Carcinoma and Follicular Variants in Dr. Kariadi Hospital, Semarang.