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All Journal Journal Pharmasci (Journal of Pharmacy and Science)
Riana Prastiwi Handayani
University of Muhammadiyah Lamongan
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Evaluation of Drug Related Problems (DRPs) in Hypertensive Patients at Muhammadiyah Lamongan Hospital: Evaluasi Drug Related Problems (DRPs) Pada Pasien Hipertensi Di Rumah Sakit Muhammadiyah Lamongan Novi Ayu Samodyaning Tyas; Irma Susanti; Riana Prastiwi Handayani
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 1 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i1.487

Abstract

Hypertensive patients often get more than one type of drug therapy to reduce cardiovascular morbidity and mortality. However, the use of too many drugs has the potential to increase the incidence of Drug Related Problems (DRPs). The incidence of DRPs resulted in an increase in health care costs and hospitalizations, length of hospital stay, decreased quality of life, and increased mortality rates.  This study aims to discover the Drug Related Problems (DRPs) that occur in hypertension patients at Muhammadiyah Lamongan Hospital. Determination of DRPs based on the classification of Drug Related Problems (DRPs) according to PCNE V9.1 of 2020. This study is a descriptive observational research with retrospective data collection using purposive sampling. The instrument used was an observation sheet. The sample in this study was hypertension patients at Muhammadiyah Lamongan Hospital in August-October 2023 who met the inclusion criteria, namely prescriptions and medical record data of outpatients with a diagnosis of hypertension at Muhammadiyah Lamongan Hospital in August-October 2023, outpatients aged ?18 years and hypertensive patients with or without comorbidities with a total of 132 patients. The results showed that of the 19 categories of DRPs studied, 6 categories of DRPs were found to occur, namely adverse drug events (probably) occurred in as many as 132 events (45.67%), inappropriate drug combinations occurred as many as 124 events (42.91%), treatment was not given or incomplete even though there were indications for 18 events (6.23%), no indications for drugs 9 events (3.11%),  The duration of treatment was too short for 5 events (1.73%), and the duration of treatment was too long for 1 event (0.35%). From the results of the study, it was concluded that the treatment obtained by hypertensive patients can cause various types of DRP events. This requires special attention so as not to increase the risk of medication errors.
The Effect of Risk Factors for Coronary Heart Disease on Transaminase Levels: Pengaruh Faktor Risiko Penyakit Jantung Koroner Terhadap Kadar Transaminase Narda Eka Rohmah Safitri; Primanitha Ria Utami; Riana Prastiwi Handayani
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 1 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i1.489

Abstract

Coronary heart disease (CHD) is caused by blood vessel blockage due to fat accumulation. Risk factors for CHD include age, gender, comorbidities, and BMI. An increase in high lipid levels in the body is an important factor in the pathophysiology of CHD. Additionally, elevated lipid levels can lead to fat accumulation in the liver, thereby increasing transaminase levels. Elevated transaminase levels can indicate heart disorders. This study aims to examine the influence of CHD risk factors on transaminase levels at Dr. Soegiri Hospital, Lamongan. This research uses cross-sectional design with descriptive analysis. Data were collected prospectively. The analysis conducted using Spearman's Rank Correlation Test. Out of 104 patients studied, 96 patients met the inclusion criteria. The analysis results showed P-value <0.05 for the risk factors of gender (P=0.00), age (P=0.00), and BMI (P=0.00) in relation to transaminase levels. These results indicate significant influence of the risk factors gender, age, and BMI on transaminase levels. In advanced age, organ function declines, affecting transaminase levels. Gender differences affect transaminase levels due to hormonal differences and liver enzyme activity, and in patients with high BMI, there is metabolic imbalance of fats, leading to fat accumulation in adipose tissues, which affects transaminase levels.
The Relationship between Medication Possession Ratio Method and Medication Adherence of Hypertension Patients at Sugio Health Center: Hubungan Metode MPR (Medication Possesion Ratio) Terhadap Kepatuhan Minum Obat Pasien Hipertensi di Puskesmas Sugio Zahrotul Wardah; Irma Susanti; Riana Prastiwi Handayani
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 1 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i1.490

Abstract

Adherence to antihypertension drug consumption drugs is one of the determining factors in controlling blood pressure. Good adherence to therapy can gradually influence blood pressure and prevent complications. This study aims to investigate the relationship between the MPR (Medication Possession Rasio) method and medication adherence in hypertension patients. The current research used descriptive method whit a cross sectional approach. The data were collected prospectively with purposive sampling. The results of the study obtained 154 samples of hypertension patients with or without comorbidities aged ?17 years. The results obtained 134 patients (87.0%) in the adherent category, and 20 patients (13.0%) who were not adherent to redeeming prescription. The results indicated that 147 patients (95.5%) had moderate adherence, 4 patients (2.6%) had high adherence, and 3 patients (1.9%) were in the low adherence category. The results of the test of the relationship between the MPR method and adherence to taking medication can be concluded that the p value = 0.017, so there is a significant relationship between the MPR method and adherence to taking medication with the ARMS (Adherence of Reffil Medication Scale) questionnaire. Even though there is a relationship, the level of relationship is very low because at the level of medication compliance, the majority of hypertension patients are in the moderate compliance category due to the age of the patient who experiences difficulties when filling out the questionnaire and the high risk of manipulation by the patient by choosing good answers.
Co-Authors Irma Susanti Narda Eka Rohmah Safitri Novi Ayu Samodyaning Tyas Primanitha Ria Utami Zahrotul Wardah