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Evaluation of Drug Related Problems (DRPs) in Hypertensive Patients at Muhammadiyah Lamongan Hospital: Evaluasi Drug Related Problems (DRPs) Pada Pasien Hipertensi Di Rumah Sakit Muhammadiyah Lamongan Novi Ayu Samodyaning Tyas; Irma Susanti; Riana Prastiwi Handayani
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 1 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i1.487

Hypertensive patients often get more than one type of drug therapy to reduce cardiovascular morbidity and mortality. However, the use of too many drugs has the potential to increase the incidence of Drug Related Problems (DRPs). The incidence of DRPs resulted in an increase in health care costs and hospitalizations, length of hospital stay, decreased quality of life, and increased mortality rates. This study aims to discover the Drug Related Problems (DRPs) that occur in hypertension patients at Muhammadiyah Lamongan Hospital. Determination of DRPs based on the classification of Drug Related Problems (DRPs) according to PCNE V9.1 of 2020. This study is a descriptive observational research with retrospective data collection using purposive sampling. The instrument used was an observation sheet. The sample in this study was hypertension patients at Muhammadiyah Lamongan Hospital in August-October 2023 who met the inclusion criteria, namely prescriptions and medical record data of outpatients with a diagnosis of hypertension at Muhammadiyah Lamongan Hospital in August-October 2023, outpatients aged ?18 years and hypertensive patients with or without comorbidities with a total of 132 patients. The results showed that of the 19 categories of DRPs studied, 6 categories of DRPs were found to occur, namely adverse drug events (probably) occurred in as many as 132 events (45.67%), inappropriate drug combinations occurred as many as 124 events (42.91%), treatment was not given or incomplete even though there were indications for 18 events (6.23%), no indications for drugs 9 events (3.11%), The duration of treatment was too short for 5 events (1.73%), and the duration of treatment was too long for 1 event (0.35%). From the results of the study, it was concluded that the treatment obtained by hypertensive patients can cause various types of DRP events. This requires special attention so as not to increase the risk of medication errors.

The Relationship Of Polypharmacy With Glomerular Filtration Rate In Patients With Chronic Kidney Failure: Hubungan Polifarmasi dengan Laju Filtrasi Glomerulus pada Pasien Gagal Ginjal Kronik Erika Cindiana Pramudia Putri; Primanitha Ria Utami; Irma Susanti
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 2 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i2.488

Polypharmacy is generally used in hemodialysis patients with an average number of drugs given being 14 drugs. In addition to detecting and preventing the severity of renal function, hemodialysis can increase the glomerular filtration rate. This study aims to determine the relationship between polypharmacy and glomerular filtration rate in patients with chronic renal failure at RSUD Dr. Soegiri Lamongan. The research design uses design descriptive with method retrospective with data collection sheet instruments, the population in this study was 174 patients, the sample was selected using techniques purposive sampling By determining the inclusion criteria, 121 patients were obtained. Data analysis using tests Spearman Rho. The results of the number of drug use in chronic kidney failure patients showed that there were more major polypharmacy incidents of ?6 drugs, as many as 115 patients (95.04%). The glomerular filtration rate in patients is mostly in the range <15 ml/minute/1,73 m2 as many as 120 patients (99.17%). The results of data analysis show that there is no relationship between polypharmacy and glomerular filtration rate p 0.820. In theory, polypharmacy is related to a decrease in glomerular filtration rate, worsening the patient's condition, resulting in undesirable side effects and drug interactions. Polypharmacy with glomerular filtration rate will result in renal dysfunction and can further exacerbate multimorbidity, so that high levels of comorbidities and chronic inflammation can lead to worse clinical consequences.

The Relationship between Medication Possession Ratio Method and Medication Adherence of Hypertension Patients at Sugio Health Center: Hubungan Metode MPR (Medication Possesion Ratio) Terhadap Kepatuhan Minum Obat Pasien Hipertensi di Puskesmas Sugio Zahrotul Wardah; Irma Susanti; Riana Prastiwi Handayani
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 1 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i1.490

Adherence to antihypertension drug consumption drugs is one of the determining factors in controlling blood pressure. Good adherence to therapy can gradually influence blood pressure and prevent complications. This study aims to investigate the relationship between the MPR (Medication Possession Rasio) method and medication adherence in hypertension patients. The current research used descriptive method whit a cross sectional approach. The data were collected prospectively with purposive sampling. The results of the study obtained 154 samples of hypertension patients with or without comorbidities aged ?17 years. The results obtained 134 patients (87.0%) in the adherent category, and 20 patients (13.0%) who were not adherent to redeeming prescription. The results indicated that 147 patients (95.5%) had moderate adherence, 4 patients (2.6%) had high adherence, and 3 patients (1.9%) were in the low adherence category. The results of the test of the relationship between the MPR method and adherence to taking medication can be concluded that the p value = 0.017, so there is a significant relationship between the MPR method and adherence to taking medication with the ARMS (Adherence of Reffil Medication Scale) questionnaire. Even though there is a relationship, the level of relationship is very low because at the level of medication compliance, the majority of hypertension patients are in the moderate compliance category due to the age of the patient who experiences difficulties when filling out the questionnaire and the high risk of manipulation by the patient by choosing good answers.

A Comparison of the Medication Adherence of Hypertension Patients Using the Medication Possession Ratio and Pill Count Methods at the Kembangbahu Health Center: Perbandingan Kepatuhan Minum Obat Pasien Hipertensi dengan Menggunakan Metode MPR (Medication Possesion Rasio) dan Pill Count di Puskesmas Kembangbahu Ariska Qurrotul Aini; Irma Susanti; Primanitha Ria Utami
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 11 No. 1 (2026): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v11i1.491

Pasien hipertensi diharuskan mengonsumsi obat setiap hari yang menyebabkan banyaknya pasien tidak mematuhi proses pengobatan sesuai yang telah dianjurkan. Kepatuhan yang rendah dapat menyebabkan risiko penyakit lain serta memperburuk keadaan pasien sehingga menyebabkan kegagalan terapi dalam proses penyembuhan. Penelitian ini bertujuan untuk mengetahui perbandingan kepatuhan minum obat pasien hipertensi dengan menggunakan metode MPR (Medication Possession Ratio) dan Pill Count. Desain penelitian yang digunakan adalah deskriptif dilakukan dengan pendekatan cross sectional. Pengumpulan data dilakukan secara prospektif dengan teknik sampling purposive sampling. Hasil penelitian yang diperoleh sebanyak 150 sampel yang telah memenuhi kriteria inklusi untuk metode MPR dan pill count. Hasil penelitian kepatuhan minum obat menunjukkan bahwa menggunakan metode Pill count memiliki jumlah pasien yang patuh lebih banyak yaitu 135 pasien (90,0%) dibandingkan dengan metode MPR yaitu 117 pasien (78,0%). Hasil uji perbandingan metode MPR dengan Pill count disimpulkan bahwa nilai p = 0,002 maka terdapat perbedaan yang signifikan antara metode MPR dan metode Pill count terhadap kepatuhan minum obat pasien hipertensi. Banyaknya ketidakpatuhan pada metode MPR ini terdapat perbedaan pada kepatuhan metode Pill count, hal ini disebabkan pasien yang tidak patuh menebus ulang resep atau melakukan kontrol kembali ke fasilitas pelayanan kesehatan pasien masih dapat mengonsumsi obat dengan mendapatkan obat di fasilitas pelayanan kefarmasian lainnya.

The Relationship Of The Medication Compliance With The Quality Of Life Of Type 2 Diabetes Mellitus Patients With Gangrene Complications: Hubungan Tingkat Kepatuhan Minum Obat terhadap Kualitas Hidup Pasien Diabetes Mellitus Tipe 2 dengan Komplikasi Gangren Wulan Dwi Jumadi; Primanitha Ria Utami; Irma Susanti
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 11 No. 1 (2026): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v11i1.495

Diabetes Mellitus (DM) type 2 is a serious and chronic disease characterized by high blood glucose levels. DM causes complications such as gangrene. The success of DM management is influenced by factors, patient compliance in taking medication, which can ultimately reduce morbidity and mortality and improve the patient's quality of life. This study aims to identify the relationship between medication adherence and the quality of life of type 2 DM patients with gangrene complications. Sampling was carried out using purposive sampling and there were 95 type 2 DM patients with gangrene at the Sahabat Sehat Karanggeneng Clinic. Respondents with type 2 diabetes mellitus had high compliance with taking medication, reaching 93% and the lowest compliance with taking medication, reaching 7%. Respondents with type 2 diabetes mellitus had a moderate quality of life, namely 10.52%, good 62.01% and very good, namely 27.47%. This research uses a non-experimental cross-sectional study method. Spearman-rank test was used to analyze the data. The research instrument used the MARS-10 questionnaire for medication adherence and Whoqol-Bref for quality of life. The results of the Spearman-rank p-value test were p=0.001. There is a significant relationship between adherence to taking medication and the quality of life of type 2 DM patients with gangrene complications. Effective management of type 2 DM and prevention of gangrene complications are very important to improve compliance and maintain patient quality of life.

Validity Dan Reliability Of Functional Assessment Of Chronic Illness Therapy Tuberculosis (FACIT-TB) Questionnaire Indonesia Version: Validasi dan Reliabilitas Kuesioner Functional Assessment of Chronic Illness Therapy Tuberculosis (FACIT-TB) Versi Indonesia Devi Ristian Octavia; Muhammad Muflih Zaku Al-Hadi; Irma Susanti; Ninik Mas Ulfa
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 11 No. 1 (2026): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v11i1.551

Tuberculosis (TB) is one of the infectious diseases that needs to be watched out for in Indonesia. TB affects the quality of life of patients, such as physical, social, emotional, functional and spiritual factors. Valid instrument measurements are needed to determine the quality of life of TB patients. FACIT-TB is a questionnaire used as a measurement of quality of life in TB patients. The purpose of this study was to determine the validity and reliability of the Indonesian version of the FACIT-TB questionnaire as a valid questionnaire. This study used a quantitative method with a sample of 110 respondents at the Lamongan Regional Health Center. The results obtained were tested using the Pearson correlation test to determine its validity while for reliability it was seen with the Cronbach alpha value. The results of the validity test were declared valid with the requirement that the calculated r value > r table. The results of all FACIT-TB questionnaire questions were declared valid. The results of the reliability test used the Cronbach alpha value with the entire domain value > 0.6. Therefore, the Indonesian version of the FACIT-TB questionnaire is a valid and reliable measurement of quality of life for TB patients. Quality of life must be measured with a valid questionnaire or instrument to obtain accurate results.

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