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All Journal RADIASI: Jurnal Berkala Pendidikan Fisika Berkala Kedokteran IJISTECH (International Journal Of Information System & Technology) Jurnal Review Pendidikan dan Pengajaran (JRPP) IJISTECH Bulletin of Computer Science Research Jurnal Manajemen Mandiri Saburai (JMMS) Prosiding Seminar Nasional Program Pengabdian Masyarakat Jurnal Ekonomika Dan Bisnis Herbal Medicine Journal Physics Learning and Education PENG: Jurnal Ekonomi dan Manajemen
Saputri, Indah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Herbal Medicine Journal

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Potensi Senyawa Kimia Ekstrak Etanol Kelakai (Stenochlaena palustris) sebagai Antitrombotik Saputri, Indah; Setiawati, Indah; Mukarramah, Mukarramah; An’nisa, Windy Sidratul; Afdella, Nor Afni; Komari, Noer
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.129

Abstract

Damage to blood vessels begins with the formation of platelet aggregation which then forms a thrombus in the artery, resulting in disruption of blood flow. Many efforts have been made to prevent platelet aggregation using herbal medicines. Kelakai is a typical Kalimantan plant thought to have antithrombotic potential. The aim of this research is to identify the potential of kelakai ethanol extract compounds as antithrombotics through in silico studies using virtual screening and molecular docking. The kelakai compound was obtained from GC-MS data taken from the ethanol extract of kelakai. The virtual screening results showed that the results of GC-MS analysis of ethanol extract found five compounds that had the potential to be antithrombotic. Molecular docking simulations with the antithrombin receptor protein (PDB ID: 1E04) show that the n-Hexadecanoic acid compound from kelakai ethanol extract has the lowest ∆G value of -8.72 kcal/mol. The n-Hexadecanoic acid compound from kelakai has potential as an antithrombotic.
Co-Authors Afdella, Nor Afni An’nisa, Windy Sidratul Ariza, Dida Rayhan Asrizal Atmaja, Faisal Azhar, Thariq Chairina Chairina, Chairina Fadillah, Roojil Farhani, Putri Fatni Mufit Feziyasti, Azifa Habibah, Hanna Heri Santoso Indah Setiawati Mahmudah, Fajira Matanari, Hanif Kurniawan Muhamad Alda Muhammad Alfarisi Muhammad Dedi Irawan Mukarramah Mukarramah, Mukarramah Nafisah Nafisah Noer Komari Permana, Andhika Cahya Praseptian, Fidela Locita Purnomo, Kristiana Felisia Raissa Amanda Putri Ramadhanti, Ayona Wulan Rifai, Faizal S, Vinna Rahmayanti Sarmila, Sarmila Setyaningsih Tyas, Woro Wiwaraning Yufis Azhar