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All Journal Jurnal Farmasi Islam Kalimantan
Putri Syahira
Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Islam Kalimantan Muhammad Arsyad Al Banjari, Banjarmasin, Kalimantan Selatan, Indonesia
Medicine & Pharmacology

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Virtual Screening Senyawa Daun Sirsak sebagai Inhibitor Potensial Antikolesterol melalui Interaksi dengan Reseptor HMG-CoA Reduktase Putri Syahira; Muhammad Fauzi; Nilly Su’aida
Jurnal Farmasi Islam Kalimantan Vol 3 No 1 (2026): Eksplorasi Strategi Terapeutik: Dari Potensi Bahan Alam hingga Evaluasi Penggunaa
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jfik.v3i1.23858

Abstract

High cholesterol is a major risk factor for cardiovascular disease and is commonly treated with statins such as simvastatin. However, long-term use may cause side effects, so safer alternative therapies are needed. This study aimed to evaluate the potential of bioactive compounds from soursop (Annona muricata) leaves as anticholesterol candidates through interaction with the HMG-CoA reductase receptor using an in silico approach. Ten bioactive compounds were docked with simvastatin as the control, and their pharmacokinetics and toxicity were predicted with pkCSM. Xylopine (-6.59 kcal/mol), isoboldine (-6.01 kcal/mol), and anomurine (-5.62 kcal/mol) showed competitive binding affinity for HMG-CoA reductase and interacted with key amino acid residues similar to those of simvastatin. ADMET analysis showed that all compounds met Lipinski’s drug-likeness criteria and had good intestinal absorption. Some compounds showed potential mutagenicity and hepatotoxicity, whereas isoboldine had a better safety profile. Overall, xylopine, isoboldine, and anomurine have potential for development as natural HMG-CoA reductase inhibitors. Further in vitro and in vivo studies are needed to confirm their effectiveness and safety as anticholesterol agents.
Co-Authors Muhammad Fauzi Nilly Su’aida