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All Journal Jurnal Farmasi Islam Kalimantan
Nilly Su’aida
Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Islam Kalimantan Muhammad Arsyad Al Banjari, Banjarmasin, Kalimantan Selatan, Indonesia
Medicine & Pharmacology

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Virtual Screening Senyawa Daun Sirsak sebagai Inhibitor Potensial Antikolesterol melalui Interaksi dengan Reseptor HMG-CoA Reduktase Putri Syahira; Muhammad Fauzi; Nilly Su’aida
Jurnal Farmasi Islam Kalimantan Vol 3 No 1 (2026): Eksplorasi Strategi Terapeutik: Dari Potensi Bahan Alam hingga Evaluasi Penggunaa
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jfik.v3i1.23858

Abstract

High cholesterol is a major risk factor for cardiovascular disease and is commonly treated with statins such as simvastatin. However, long-term use may cause side effects, so safer alternative therapies are needed. This study aimed to evaluate the potential of bioactive compounds from soursop (Annona muricata) leaves as anticholesterol candidates through interaction with the HMG-CoA reductase receptor using an in silico approach. Ten bioactive compounds were docked with simvastatin as the control, and their pharmacokinetics and toxicity were predicted with pkCSM. Xylopine (-6.59 kcal/mol), isoboldine (-6.01 kcal/mol), and anomurine (-5.62 kcal/mol) showed competitive binding affinity for HMG-CoA reductase and interacted with key amino acid residues similar to those of simvastatin. ADMET analysis showed that all compounds met Lipinski’s drug-likeness criteria and had good intestinal absorption. Some compounds showed potential mutagenicity and hepatotoxicity, whereas isoboldine had a better safety profile. Overall, xylopine, isoboldine, and anomurine have potential for development as natural HMG-CoA reductase inhibitors. Further in vitro and in vivo studies are needed to confirm their effectiveness and safety as anticholesterol agents.
Uji Aktivitas Anti Depressant dan Anxiolytic pada Ekstrak Akar Kuning (Arcangelisia flava L.) dengan Metode In Vivo Noor Khalida; Nilly Su’aida; Aris Fadillah
Jurnal Farmasi Islam Kalimantan Vol 3 No 1 (2026): Eksplorasi Strategi Terapeutik: Dari Potensi Bahan Alam hingga Evaluasi Penggunaa
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jfik.v3i1.24606

Abstract

Depressive and anxiety disorders are common mental health problems across age groups and a health priority in Indonesia. Synthetic antidepressants such as SSRIs and TCAs often cause side effects, so natural alternatives are needed. One promising plant is yellow root (Arcangelisia flava L.), which contains the alkaloid berberine as well as flavonoids, saponins, tannins, and terpenoids with pharmacological activity. This study aimed to determine the antidepressant and anxiolytic activity of the 70% ethanol extract of yellow root in vivo and to identify the most effective dose. Sixty male Swiss Webster mice were divided into five groups: negative control (0.9% NaCl), positive control (amitriptyline 25 mg/kg BW), and three treatment groups receiving the extract at 50, 75, and 100 mg/kg BW. Antidepressant activity was tested with the forced swimming test (FST) and the tail suspension test (TST), and anxiolytic activity with the elevated plus maze (EPM). The 70% ethanol extract of yellow root had a significant antidepressant effect at 100 mg/kg BW (p < 0.021 in the FST and p < 0.001 in the TST), while the positive control showed the lowest immobility. The EPM test showed no significant difference (p > 0.05), so the anxiolytic effect of the extract was not statistically demonstrated.
Co-Authors Aris Fadillah Muhammad Fauzi Noor Khalida Putri Syahira