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All Journal Jurnal Farmasi Islam Kalimantan
Noor Khalida
Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Islam Kalimantan Muhammad Arsyad Al Banjari, Banjarmasin, Kalimantan Selatan, Indonesia
Medicine & Pharmacology

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Uji Aktivitas Anti Depressant dan Anxiolytic pada Ekstrak Akar Kuning (Arcangelisia flava L.) dengan Metode In Vivo Noor Khalida; Nilly Su’aida; Aris Fadillah
Jurnal Farmasi Islam Kalimantan Vol 3 No 1 (2026): Eksplorasi Strategi Terapeutik: Dari Potensi Bahan Alam hingga Evaluasi Penggunaa
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jfik.v3i1.24606

Abstract

Depressive and anxiety disorders are common mental health problems across age groups and a health priority in Indonesia. Synthetic antidepressants such as SSRIs and TCAs often cause side effects, so natural alternatives are needed. One promising plant is yellow root (Arcangelisia flava L.), which contains the alkaloid berberine as well as flavonoids, saponins, tannins, and terpenoids with pharmacological activity. This study aimed to determine the antidepressant and anxiolytic activity of the 70% ethanol extract of yellow root in vivo and to identify the most effective dose. Sixty male Swiss Webster mice were divided into five groups: negative control (0.9% NaCl), positive control (amitriptyline 25 mg/kg BW), and three treatment groups receiving the extract at 50, 75, and 100 mg/kg BW. Antidepressant activity was tested with the forced swimming test (FST) and the tail suspension test (TST), and anxiolytic activity with the elevated plus maze (EPM). The 70% ethanol extract of yellow root had a significant antidepressant effect at 100 mg/kg BW (p < 0.021 in the FST and p < 0.001 in the TST), while the positive control showed the lowest immobility. The EPM test showed no significant difference (p > 0.05), so the anxiolytic effect of the extract was not statistically demonstrated.
Co-Authors Aris Fadillah Nilly Su’aida