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All Journal Jaringan Laboratorium Medis
Rizqi Mukramiin Marpaung
Poltekkes Kemenkes Semarang
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Public Health

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Sitotoksisitas Ekstrak Bunga Pepaya (Carica papaya L) Terhadap Sel Kanker Payudara T47D Rachmad Bayu Kuncara; Rizqi Mukramiin Marpaung; Teguh Budiharjo; Rodhi Hartono
Jaringan Laboratorium Medis Vol 8 No 2 (2026): November 2026
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v8i2.15430

Abstract

Breast cancer is the type of cancer with the highest prevalence in Indonesia that affects women. Carica papaya L is classified as a plant that has various activities as antioxidants and anti-cancer due to the content of phytochemicals, including flavonoids, saponins, and tannins that can induce apoptosis of cancer cells. This study aims to determine the cytotoxicity of papaya flower extract (Carica papaya L) against T47D breast cancer cells based on IC50 value. This research is a pure experiment. T47D breast cancer cell culture group was given papaya flower extract (Carica papaya L.) with a concentration series, namely 100, 200, 300, 400 and 500 μg/ml. After that, the cytotoxic test of MTT assay method was conducted. The results indicated that an increase in treatment concentration had an impact on decreasing cell viability. The final result obtained IC50 value using Graphad Prism software obtained IC50 value on papaya flower extract of 115.6 µg/ml which shows moderate cytotoxic activity against T47D breast cancer cells. Based on this study, it can be concluded that papaya flower extract (Carica papaya L) affects the viability of T47D breast cancer cells with an IC₅₀ value of 115.6 µg/ml.
Co-Authors Rachmad Bayu Kuncara Rodhi Hartono Teguh Budiharjo