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All Journal Biology, Medicine, & Natural Product Chemistry
Riesthy Achri Adha
Universitas Mohammad Natsir Bukittinggi
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Comparison of the Effectiveness of Maceration and Soxhlet Extraction Methods on the Phytochemical Profile and Total Flavonoid Content of Bandotan Leaf Fractions (Ageratum conyzoides L.) Tika Afriani; Linda Hevira; Riesthy Achri Adha
Biology, Medicine, & Natural Product Chemistry Vol 15, No 2 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.152.1961-1966

Abstract

This study aimed to compare the efficiency of cold (maceration) and hot (Soxhlet) extraction methods in obtaining total flavonoids. Extraction was performed using 96% ethanol solvent, followed by fractionation using n-hexane and ethyl acetate. The content was determined using validated UV-Vis spectrophotometry. The validation results showed that the method met the requirements for linearity (r=0.9988), accuracy (99.51%), LOD (2.19 ppm), and LOQ (7.30 ppm). The results of the content determination showed that the ethyl acetate fraction of the Soxhlet extraction method provided the highest flavonoid content of 251.04 ± 0.24 mgQE/g, which was significantly different from the maceration method (194.14 ± 0.49 mgQE/g). In conclusion, the Soxhlet extraction method is more effective in extracting flavonoid compounds from bandotan leaves than maceration due to continuous solvent circulation and heat assistance.
Co-Authors Linda Hevira Tika Afriani