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All Journal Jurnal Riset Kimia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Katalisator Journal of Science and Clinical Pharmacy Research
Linda Hevira
Program Studi Farmasi Universitas Mohammad Natsir Bukittinggi
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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Uji Aktivitas Antioksidan dan Fenolik Total Fraksi Etil Asetat Daun Sembung (Blumea balsamifera (L.) DC) Azimatur Rahmi; Tika Afriani; Linda Hevira; Wike Widiawati
Jurnal Riset Kimia Vol. 12 No. 2 (2021): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.383

Abstract

The aim of this study is to investigate antioxidant activity and total phenolic content of ethyl acetate fraction of Sembung leaves. Sembung (Blumea balsamifera L.) is a plant that has the potential as an antioxidant because it contains secondary metabolites of alkaloids, steroids, flavonoids, saponins, and phenolic compounds. In this study, antioxidant activity was tested by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) for free radical scavenging activity assay. Evaluation of total phenolic content was tested by using the Folin-Ciocalteau method. The results showed that the ethyl acetate fraction of Sembung leaves possess showed medium antioxidant activity with IC50 valueof 221.821 compare with reference standard ascorbic acid with IC50 value 68.25 ppm. The ethyl acetate fraction of Sembung leaves has a total phenolic content of 161.101 mg GAE/g. This study provided that Blumea balsamifera leaves possess antioxidant.
AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT PISANG KEPOK, PISANG MAS DAN PISANG NANGKA MENGGUNAKAN METODE DPPH Azimatur Rahmi; Nadya Hardi; Linda Hevira
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (697.547 KB) | DOI: 10.31942/jiffk.v18i2.5961

Abstract

Banana is one of the most common crops in Indonesia. Banana peel contains phenolic antioxidant compounds. This study used extraction, DPPH, and spectrophotometry to determine the potential antioxidant activity of three types of banana peels, namely kepok banana peel, trout banana peel, and jackfruit banana peel. Banana peel simplisia powder was extracted by maceration using 96% ethanol as solvent. The resulting banana peel extract was then phytochemical screening for flavonoid compounds, tannins, alkaloids, steroids, and terpenoids. This antioxidant activity test used a qualitative method using TLC and quantitative method with reagent of 0.2 N DPPH by UVVis spectrophotometry. The results showed that the three banana peels tested had antioxidant activity and it is classified as active. The IC50 values for the ethanolic extracts of kepok banana peel, trout banana peel, and jackfruit banana peel were 9,702 ppm, 13,322 ppm and 10,747 ppm respectively. Ascorbic acid as a comparison obtained an IC50 value of 9,613 ppm. From the data obtained, kepok banana peel extract has the highest antioxidant than extract of trout banana peel, and jackfruit banana peel. 
Analisis Merkuri Pada Merk Krim Pemutih Wajah dengan Metode Spektrofotometri Serapan Atom Rahma Yulia; Annisa Putri; Linda Hevira
Jurnal Katalisator Vol 4, No 2 (2019): KATALISATOR
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jk.v4i2.4618

Abstract

Telah dilakukan penelitian “Analisis Merkuri (Hg) pada Beberapa Merek Krim Pemutih Wajah dengan Metode Spektrofotometri Serapan Atom (SSA)”. Tujuan penelitian yang dilakukan untuk mengidentifikasi dan mengukur kadar merkuri dalam beberapa merek krim pemutih wajah yang dijual di pasaran Kota Bukittinggi. Sampel diekstraksi dengan cara destruksi basah selama 3 jam pada suhu ±100°C sampai diperoleh larutan bening. Analisa kualitatif merkuri menggunakan KI 0,5 N dan NaOH 2 N. Kemudian, penentuan merkuri dalam sampel menggunakan Spektrofotometri Serapan Atom Uap Dingin. Dari hasil validasi metode diperoleh persamaan regresi Y = 0,0072x – 0,0089. Hasil penelitian menunjukkan bahwa dari kelima sampel yang diuji mengandung merkuri dengan rata-rata kadar sampel A = 0,00087 ppm, B = 0,00075 ppm, C = 0,00066 ppm, D = 1,66794 ppm, dan E = 0,00189 ppm. Sampel D mengandung merkuri di atas batas aman yang diperbolehkan BPOM RI yaitu tidak melebihi 1 mg/L atau 1 ppm. This research has been done Analysis of Mercury on Several Brands of Whitening Creams by using Atomic Absorption Spectrophotometry Method. The purpose of this research was to identify and measure mercury consentrations on five samples of whitening cream in the market Bukittinggi City. The samples was extracted by wet destruction for 3 hours at ± 100 °C until the solution clear. Qualitative analysis was performed using color test KI 0.5 N and NaOH 2 N. Then, the determination of mercury in the samples by using Cold Vapour Atomic Absorption Spectrophotometry. The regression equation obtained from the calibration curve is Y = 0,0072x – 0,0089. The results of the five samples showed that all samples contained mercury with average level samples A = 0,00087 ppm, B = 0,00075 ppm, C = 0,00066 ppm, D = 1,66794 ppm, dan E = 0,00189 ppm. Sample D contained mercury above the safe limit allowed by BPOM RI that is not more than 1 mg/L or 1 ppm.
PEMBUATAN DAN KARAKTERISTIK MULTIKOMPONEN KRISTAL IBUPROFEN DAN ASAM SITRAT DENGAN METODE SOLVENT EVAPORATION Sonya Fiola; Rido Farnandi; Linda Hevira; Devahimer Harsep Rosi
Journal of Science and Clinical Pharmacy Research Vol. 1 No. 2 (2025): August 2025
Publisher : LPPM Universitas Mohammad Natsir Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1144/jscpr.v1i2.306

Abstract

Ibuprofen merupakan obat antiinflamasi non-steroid (NSAID) yang tergolong dalam Biopharmaceutical Classification System (BCS) kelas II, yaitu memiliki kelarutan rendah dan permeabilitas tinggi. Salah satu untuk meningkatkan kelarutan dan disolusi ibuprofen adalah melalui pembentukan multikomponen kristal dengan koformer yang sesuai. Penelitian ini bertujuan untuk membuktikan terbentuknya multikomponen kristal ibuprofen dengan asam sitrat melalui metode solvent evaporation serta mengevaluasi karakteristik fisikokimia dan profil disolusinya. Hasil FT-IR menunjukkan pergeseran bilangan gelombang yang mengindikasikan adanya interaksi intermolekul berupa ikatan hidrogen. Hasil XRD menunjukkan terbentuknya fase kristalin baru. Penetapan kadar ibuprofen dalam multikomponen kristal menunjukkan nilai 98,83%, yang sesuai dengan standar Farmakope Indonesia (97–103%). Uji disolusi dilakukan dalam medium dapar fosfat pH 7,2. Persentase zat terdisolusi ibuprofen pada menit ke-30 adalah 42,21%, sedangkan multikomponen kristal mencapai 88,27%. Rata-rata efisiensi disolusi (ED) ibuprofen sebesar 25,53%, sementara multikomponen kristal sebesar 84,25%, menunjukkan peningkatan yang signifikan. Uji statistik menggunakan independent t-test dengan SPSS versi 26 menunjukkan nilai signifikansi p < 0,05 untuk kedua sampel (ibuprofen dan multikomponen kristal), yang mengindikasikan adanya perbedaan yang signifikan antara keduanya dalam laju disolusi.
Co-Authors Annisa Putri Azimatur Rahmi Azimatur Rahmi Devahimer Harsep Rosi Nadya Hardi Rahma Yulia Rido Farnandi Sonya Fiola Tika Afriani Wike Widiawati