ABSTRAK Pasien Gagal Ginjal Kronik (GGK) yang menjalani terapi hemodialisis berisiko tinggi mengalami komplikasi infeksi akses vaskular, yang dipicu oleh kurangnya pemahaman dan teknik perawatan mandiri yang tepat di rumah. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan pasien GGK serta keluarga dalam mencegah infeksi akses vaskular melalui penggunaan media edukasi booklet. Kegiatan dilaksanakan di Unit Hemodialisis RS Bhayangkara Lumajang dengan melibatkan 40 pasien dan keluarga. Metode mencakup analisis kebutuhan, pre-test, penyuluhan interaktif, demonstrasi perawatan akses vaskular, serta evaluasi melalui post-test dan observasi keterampilan. Hasil pre-test menunjukkan mayoritas peserta berada pada kategori pengetahuan kurang. Setelah intervensi edukasi berbasis booklet, terjadi peningkatan rerata skor pengetahuan yang signifikan (p = 0,000) dan sebagian besar peserta mampu menerapkan langkah pencegahan infeksi serta mengenali tanda-tanda infeksi dengan benar. Pemberdayaan berbasis media edukasi booklet efektif meningkatkan pengetahuan dan keterampilan pencegahan infeksi akses vaskular pada pasien hemodialisis dan keluarga. Kata Kunci: Gagal Ginjal Kronik, Hemodialisis, Akses Vaskular, Pencegahan Infeksi, Booklet. ABSTRACT Chronic Kidney Disease (CKD) patients undergoing hemodialysis are at high risk of vascular access infection, which is often exacerbated by lack of knowledge and improper home self-care. This community service activity aimed to improve the knowledge and skills of CKD patients and their families in preventing vascular access infection using booklet-based educational media. The activity was conducted at the Hemodialysis Unit of RS Bhayangkara Lumajang, involving 40 patients and family caregivers. The methodology included needs assessment, pre-test, interactive health education, demonstrations of vascular access care, and evaluation via post-test and skill observation. Pre-test results indicated that most participants had poor initial knowledge. Following the booklet-based intervention, a significant increase in mean knowledge scores was observed (p = 0.000), with most participants demonstrating correct infection prevention practices and early identification of infection symptoms. Empowerment through booklet-based educational media is effective in enhancing the knowledge and skills required for vascular access infection prevention among hemodialysis patients and their families. Keywords: Chronic Kidney Disease, Hemodialysis, Vascular Access, Infection Prevention, Booklet.