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All Journal Jurnal Natur Indonesia Chemistry Indonesian Journal of Chemical Research Science Map Journal Molluca Journal of Chemistry Education (MJoCE) Pakem : Jurnal Pengabdian Kepada Masyarakat Makara Journal of Science
Nazudin, Nazudin
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Synthesis and Antimalarial Activity of 2-Phenyl-1,10-Phenanthroline Derivative Compounds Hadanu, Ruslin; Mustofa, Mustofa; Nazudin, Nazudin
Jurnal Natur Indonesia Vol 15, No 1 (2013)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.973 KB) | DOI: 10.31258/jnat.15.1.57-62

Abstract

To develop new potential antimalarial drugs of 2-phenyl-1,10-phenanthroline 5 derivatives from 8-aminoquinoline as startingmaterial were synthesized in good yields. The synthesis of 2-phenyl-1,10-phenanthroline 5 derivatives compoundswith 8-aminoquinoline 4 as starting material through three steps has been carried out. The first step of reactions is aldolcondensation of benzaldehyde 1 with acetaldehyde 2. The result of reactions is cinnamaldehyde 3 (92.14%) in the form ofyellow solid. The second step of reactions was synthesized of 2-phenyl-1,10-phenanthroline 5 (brown solid, 54.63%)through cyclization of 8-aminoquinoline 4 with cinnamaldehyde 3 compound. The third step of reactions is methylation andethylation of 2-phenyl-1,10-phenanthroline using dimethyl sulphate (DMS) and diethyl sulphate (DES) reagents that it wasrefluxed for 17 and 19 h, respectively. The results of reactions are (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate 6and (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate 7 in yield from 90.62% and 89.70%, respectively. The results oftesting in vitro antiplasmodial activity at chloroquine-resistant Plasmodium falciparum FCR3 strain to 2-phenyl-1,10-phenanthroline 5 derivatives obtained that (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate 7 compound has higherantimalarial activity (IC 50 :0.13 ± 0.02 μM) than antimalarial activity of (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate6 compound (IC 50 :0.25 ± 0.01 μM) and 2-phenyl-1,10-phenanthroline 5 compound (IC 50 :2.45 ± 0.09 μM). While, the resultsof testing in vitro antiplasmodial activity at chloroquine-resistant Plasmodium falciparum D10 strain to 2-phenyl-1,10-phenanthroline 5 derivatives obtained that (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate 6 compound has higherantimalarial activity (IC 50 :0.10± 0.04 μM) than antimalarial activity of (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate7 (IC 50 :0.18 ± 0.01 μM) and 2-phenyl-1,10-phenanthroline 5 compound (IC 50 :0.55 ± 0.07 μM).
Synthesis and Antiplasmodial Activity of 2-(4-Methoxyphenyl)-4-Phenyl-1,10- Phenanthroline Derivative Compounds Hadanu, Ruslin; Mustofa, Mustofa; Nazudin, Nazudin
Makara Journal of Science Vol. 16, No. 2
Publisher : UI Scholars Hub

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Abstract

A unique of synthetic methods was employed to prepare 2-(4-methoxyphenyl)-4-phenyl-1,10-phenanthroline (5) derivatives from 4-methoxy-benzaldehyde (1), acetophenone (2), and 8-aminoquinoline (4) with aldol condensation and cyclization reactions. The derivatives were tested through antiplasmodial test. The synthesis of derivatives compound 5 was conducted in three steps. The 3-(4-methoxyphenyl)-1-phenylpropenone 3 was synthesized through aldol condensation of 1 and 2 which has a yield of 96.42%. The compound 5 was synthesized through cyclization of compound 4 and 3 with 84.55% yield. The derivative of compound 5 was synthesized from compound 5 using DMS and DES reagents which refluxed for 21 and 22 h, to produce (1)-N-methyl-9-(4-methoxyphenyl)-7-phenyl-1,10- phenanthrolinium sulfate (6) and (1)-N-ethyl-9-(4-methoxyphenyl)-7-phenyl-1,10-phenanthrolinium sulfate (7) with 91.42 and 86.36% yields, respectively. Results of in vitro testing of antiplasmodial activity of compound 5 derivatives (i.e., compound 6 and 7) against chloroquine-resistant P. falciparum FCR3 strain showed that compound 7 had higher antimalarial activity than compounds 5 and 6. Whereas, results of in vitro testing against chloroquine-sensitive P. falciparum D10 strain showed that compound 6 has higher antimalarial activity than compounds 5 and 7.
ADSORPSI ASAM LEMAK BEBAS MINYAK JELANTAH MENGGUNAKAN SILIKA GEL DARI ABU LAYANG KELAPA SAWIT Sunarti, sunarti; Reubun, Mayang; Nazudin, Nazudin
Molluca Journal of Chemistry Education (MJoCE) Vol 14 No 1 (2024): MJoCE
Publisher : Program Studi Pendidikan Kimia, FKIP, Universitas Pattimura (Chemistry Education Study Program, Faculty of Teacher Training and Educational Sciences, Pattimura University)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/MJoCEvol14iss1pp28-37

Abstract

Penelitian ini bertujuan untuk mengetahui karakteristik silika gel hasil sintesis dari abu layang kelapa sawit dan kemampuannya dalam mengadsorpsi asam lemak bebas pada minyak jelantah.Sintesis silika gel menggunakan metode sol gel, dan proses adsorpsi dilakukan secara batch. Penentuan konsenrasi asam lemak dilakuka dengan metode titrasi. Hasil analisis XRD dari silika gel hasil sintesis menunjukkan puncak melebar pada 2θ= 15-30o dimana puncak tertinggi adalah pada 2θ=22,40o yang mengindikasikan silika gel hasil sintesis merupakan material yang bersifat amorf. Hasil analsis silika gel menggunakan FTIR memberikan serapan Vibrasi rentang gugus OH dari gugus silanol (Si-OH) muncul pada bilangan gelombang 3495,51cm-1. Serapan pada bilangan gelombang 1625,99 cm-1 merupakan vibrasi tekuk dari gugus Si-OH. Pada bilangan gelombang 1083 cm-1 menunjukkan vibrasi ulur asimetri Si-O dari Si-O-Si (gugus siloksan) dan adanya vibrasi ulur ini diperkuat dengan adanya serapan pada bilangan gelombang 798,53 cm-1. Pada bilangan gelombang 462,92 cm-1 menunjukkan adanya vibrasi tekuk Si-O dari gugus fungsi Si-O-Si. Kadar asam lemak bebas minyak jelantah awal sebesar 1,024%. Setelah proses adsorpsi penurunan kadar asam lemak bebas tertinggi diperoleh pada waktu kontak 90 menit sebesar 0,59% dengan Kapasitas dan efisiensi adsorpsi sebesar 9,65 mg/g dan 42,383%. Berdasarkan hasil yang diperoleh maka proses adsorpsi menggunakan silika gel dari abu layang kelapa sawit dapat menurunkan asam lemak bebas sehingga dapat memenuhi syarat SNI 01-3741-2013 yaitu maksimal 0,6%.
Patchouli Oil Isolation and Identification of Chemical Components Using GC-MS Souhoka, Fensia Analda; Al Aziz, Andi Zulkifli; Nazudin, Nazudin
Indonesian Journal of Chemical Research Vol 8 No 2 (2020): Edition for September
Publisher : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2020.8-fas

Abstract

This research aims to isolate oil from patchouli (Pogostemon cablin Benth) and identify the chemical components of patchouli oil using Gas Chromatography-Mass Spectrometry (GC-MS). Patchouli plant samples were obtained from Welulu Village, Kolaka Regency, Southeast Sulawesi Province. Fresh patchouli leaves are dried in the sun for four days to a constant weight. Patchouli leaves water content is 77.41% (w/w). Dry patchouli leaves are distilled using the water and steam method for two hours. Water and oil distillates are separated using a separating funnel. Patchouli oil obtained was dried using Na2SO4 anhydrous and yield 0.73% (w/w). The results of GC-MS analysis showed that patchouli oil contained 13 chemical components compounds, namely β-patchoulene (4.56%), cedr-8-ene (1.24%), trans-caryophyllene (7.96%), α-guaiene (18.61%), seychellene (5.70%), patchoulene (2.88%), eremophilene (1.33%), azulene (8.74%), delta-guaiene (18.90%), cyclohexanone (1.10%), globulol (1.88%), veridiflorol (4.39%), and alcohol patchouli (22.7%).
APLIKASI REAKSI REDOKS SECARA KONTEKSTUAL BAGI SISWA KELAS XII SMA NEGERI 6 MALUKU TENGAH Sunarti, Sunarti; Nazudin, Nazudin; Untailawan, Romelos
PAKEM : Jurnal Pengabdian Kepada Masyarakat Vol 4 No 2 (2024): Pakem : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/pakem.4.2.182-191

Abstract

Kegiatan ini bertujuan untuk memberikan informasi dan pengetahuan kepada siswa kelas XII MIA 2 SMA Negeri 6 Maluku Tengah tentang reaksi redoks dalam kehidupan sehari-hari serta mempraktekkannya menggunakan alat dan bahan yang sederhana di sekitar lingkungan siswa. Kegiatan ini terdiri dari tiga tahap yaitu persiapan, pelaksanaan dan evaluasi. Pelaksanaan kegiatan dimulai dengan memberikan materi dan dilanjutkan dengan praktikum menggunakan bahan-bahan sederhana.Siswa menyimak semua materi yang diberikan dan antusias melakukan keempat percobaan sesuai dengan prosedur. Siswa begitu senang dengan setiap perubahan yang terjadi pada semua percobaan, baik perubahan warna, pembentukan gas dan endapan serta adanya ledakan dan percikkan api. Pada tahap evaluasi, siswa diberikan kuisioner untuk mengetahui respon terhadap kegiatan yang dilakukan. 89% siswa memberikan respon sangat baik dan baik terhadap penyajian materi, praktikum, serta suasana kegiatan. Kegiatan yang dilakukan ini membuat siswa senang dan tidak bosan dalam mempelajari reaksi redoks yang dianggap sulit dan membosankan oleh kebanykan siswa.
AKTIVASI MASSA ABU CANGKANG DAN SABUT KELAPA SAWIT UNTUK ADSORPSI ZAT WARNA METILEN BIRU Aurellia, Annisa; Sunarti, Sunarti; Nazudin, Nazudin
Science Map Journal Vol 7 No 1 (2025): Science Map Journal
Publisher : Jurusan Pendidikan MIPA FKIP Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/jmsvol7issue1pp22-28

Abstract

Metilen biru adalah limbah pewarna cair yang banyak dihasilkan oleh pabrik atau industri tekstil, limbah cair tersebut mengandung bahan-bahan berbahaya dan beracun yang menimbulkan iritasi pada saluran pencernaan dan iritasi pada kulit sehingga perlu dilakukan pengolahan limbah metilen biru dengan cara adsorpsi. Penelitian ini bertujuan untuk mengetahui kapasitas dan efisiensi adsorpsi abu cangkang dan sabut kelapa sawit teraktivasi dan tanpa aktivasi terhadap zat warna metilen biru berdasarkan variasi massa adsorben. Proses aktivasi dilakukan dengan perendaman abu cangkang dan sabut kelapa sawit dalam H2SO4 2% disertai pemanasan pada suhu 100oC. Proses adsorpsi dilakukan dengan variasi massa adsorben 0.5; 1.0; 1.5; 2.0; dan 2.5 gram dan konsentrasi metilen biru dianalisis menggunakan spektrofotometer UV-Vis. Berdasarkan hasil penelitian diperoleh massa abu cangkang dan sabut kelapa sawit teraktivasi dan tanpa aktivasi adalah sama, dengan kapasitas adsorpsi sebesar 0.4559 mg/g, dan efisiensi adsorpsi 91.18% untuk abu teraktivasi, sedangkan untuk abu tanpa aktivasi sebesar 0.453 mg/g dan 90.62%.
Co-Authors Al Aziz, Andi Zulkifli Aurellia, Annisa Fensia Analda Souhoka Mustofa Mustofa Reubun, Mayang Ruslin Hadanu Sunarti Untailawan, Romelos