This study was conducted to analyze the effect of employee transfers on performance optimization and work environment quality at PT Indomaret Medan Branch. Employee transfer is one of the human resource management strategies implemented by companies to improve organizational effectiveness through the placement of employees according to their abilities, skills, and operational needs. This research employed a quantitative approach with an associative research design. The study population consisted of 874 office employees of PT Indomaret Medan Branch, with a sample of 672 respondents selected using the Proportional Random Sampling technique. Data were collected through questionnaires designed based on a Likert scale. Furthermore, the data were analyzed using SPSS version 26 through a series of statistical tests, including validity testing, reliability testing, classical assumption testing, multiple linear regression analysis, t-test, F-test, and coefficient of determination (R²). The results revealed that employee transfers have a positive and significant effect on employee performance optimization. This finding is indicated by a t-value of 8.549 with a significance level of 0.000. On the other hand, work environment quality was also proven to have a positive and significant effect on employee performance optimization, with a t-value of 10.854 and a significance level of 0.000. Simultaneous testing showed that employee transfers and work environment quality jointly have a positive and significant effect on employee performance optimization, as indicated by an F-value of 186.472 with a significance level of 0.000. In addition, the coefficient of determination (R²) of 0.531 indicates that 53.1% of the variation in employee performance optimization can be explained by these two variables, while the remaining 46.9% is influenced by other factors not examined in this study.