Chemistry learning in madrasahs still relies heavily on lecture-based methods and conventional media such as PowerPoint presentations and Student Worksheets (LKPD), making it difficult for students to visualize abstract chemistry concepts. A preliminary study at Madrasah Tarbiyah Islamiyah (MTI) Canduang found that 84.6% of eleventh-grade students experienced difficulties in understanding chemistry through conventional learning, while 61.5% regularly played digital games in their leisure time, indicating an opportunity to adopt a game-based learning approach. This study aimed to develop a gamified interactive chemistry learning medium using Roblox Studio for eleventh-grade students at MTI Canduang that is valid, practical, and effective. The study employed a Research and Development (R&D) approach using the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation) involving 24 students from Class XI 1 of MTI Canduang. Data were collected through observations, interviews, and questionnaires during the analysis stage; validation questionnaires completed by three media validators, two content validators, and two language validators; practicality response questionnaires completed by two chemistry teachers; and learning outcome tests using a pretest-posttest design administered to all students. The analysis stage confirmed students’ strong interest in three-dimensional, game-based learning environments covering acid-base equilibrium, solubility product, hydrolysis, buffer solutions, and titration. The design stage produced a storyboard consisting of six progressive mission levels equipped with a points system, badges, and quizzes, which were developed through the creation of virtual maps and Lua scripts in Roblox Studio. The results showed that the media was valid, with Aiken’s V values of 0.95 for construct validity, 0.95 for content validity, and 0.91 for language validity; highly practical, with a teacher response score of 91.8%; and effective, with an N-Gain score of 0.81 (high-g category), indicated by an increase in the average score from 15.25 to 27.67. These findings demonstrate that Roblox Studio can serve as an effective and adaptive alternative learning medium for madrasahs with limited laboratory facilities.