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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Eduvest - Journal of Universal Studies Gema Lingkungan Kesehatan Indonesian Basic and Experimental Health Sciences
Ariningrum, Dian
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Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Correlation between Plasma Osteopontin and Alkaline Phosphatase in Type 2 Diabetes Mellitus Patients Sinambela, Josua TH; Pramudianti, M.I Diah; Ariningrum, Dian
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1468

Abstract

Diabetes Mellitus (DM) is a chronic disease caused by pancreas the inability to produce insulin or ineffectively insulin use.Fracture risk in type 2 DM patients increases even though the bone density is normal. This study aimed to examine thecorrelation of osteopontin (OPN) and alkaline phosphatase (ALP) in type 2 DM patients. An observational analytical studywas conducted in 73 type 2 DM patients in Dr. Moewardi Hospital, Surakarta from October to November 2018. The subjectswere examined for blood pressure, fasting blood glucose, two hours postprandial blood glucose, HbA1c, OPN, and ALPlevels. P-value <0.05 was statistically significant with a 95% confidence interval. Poorly controlled type 2 DM had higher OPNlevels than well-controlled (20.5±2.8 vs. 14.8±3.1 ng/mL, p <0.001). The ALP concentration was also higher in poorlycontrolled type 2 DM patients (79.9±31.7 vs. 61.1±25 U/L, p=0.003). The levels of OPN and ALP were significantly correlatedin type 2 diabetes (r=0.273; p=0.020) and in well-controlled patients (r=0.353; p=0.047) but no correlation was found inpoorly controlled type 2 DM patients (r= -0.073; p= 0.652). In this study, a significant correlation was found between OPNand ALP in patients with type 2 DM and well-controlled. Further study involving healthy controls and bone ALPmeasurement is needed.
The Role of Bleeding History: Mortality Risk Acute Leukimia Senaputra , Mas Aditya; Ariningrum, Dian; Immakulata Diah Pramudianti, Maria; Ratnani, Daniela; Sidharta, B. Rina Aninda; Eka Rezkita, Bastomy; Putri, Desi Puspa
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.293

Abstract

Acute leukemia is a malignant hematological disease with a low survival rate. The survival rate of acute leukemia patients is influenced by several factors, one of which is a history of bleeding. This study aimed to evaluate whether a history of bleeding constitutes an independent risk factor for mortality in patients diagnosed with acute leukemia at Dr. Moewardi Regional General Hospital, Surakarta. This study employed an observational and analytical retrospective cohort design. The subjects were patients diagnosed for the first time with acute leukemia by bone marrow puncture (BMP) and immunophenotyping from January to December 2023. The data was analyzed using chi-square for bivariate analysis and multivariate logistic regression. Survival analysis was performed using the Kaplan-Meier test. A total of 124 patients were included in the analysis. Bivariate analysis demonstrated that both history of bleeding (p = 0.008) and leukocyte count (p = 0.001) were significantly associated with mortality. Multivariate logistic regression confirmed that a history of bleeding (p = 0.027; relative risk [RR] = 3.45) and leukocyte count exceeding 50,000 cells/μL (p = 0.002; RR = 5.10) were independently associated with reduced survival. Kaplan-Meier survival curves showed lower cumulative survival among patients with a history of bleeding and those with elevated leukocyte counts. A history of bleeding is an independent risk factor for decreased survival in patients with acute leukemia at Dr. Moewardi Regional General Hospital. Additionally, leukocyte counts exceeding 50,000 cells/μL are associated with significantly worse survival outcomes.
PROFIL TIROID, AUTOANTIBODI TIROID DAN RT-PCR SARS CoV-2 SERUM PADA PASIEN COVID-19 Pramudianti, M I Diah; Ariningrum, Dian; Sulistyantoko, Damar; Fitriastuti, Avanti
Indonesian Basic and Experimental Health Sciences Vol. 12 No. 1 (2023): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol12iss1pp1-9

Abstract

PENDAHULUAN Penyakit tiroid merupakan masalah kesehatan masyarakat yang harus diwaspadai karena dapat mempengaruhi berbagai organ tubuh. Penyakit COVID-19 dapat memacu gangguan tiroid secara direk atau melalui respon inflamasi imun yang memacu autoimun. Tujuan penelitian ini untuk menganalisis profil tiroid, autoantibodi tiroid dan RT-PCR SARS CoV-2 serum pada pasien COVID-19 METODE Penelitian potong lintang dengan sampling berurutan pada bulan Juli 2022 sampai dengan Oktober 2022 di laboratorium Patologi Klinik RSUD Dr. Moewardi di Surakarta. Kriteria inklusi yaitu pasien dewasa dengan COVID-19. Kadar TSH, FT4, FT3, dan TPO antibody diperiksa menggunakan alat imunologi Mindray CL-900i metode CLIA. RT-PCR SARS CoV-2 serum menggunakan alat Roche Cobas Z 480. Data diproses menggunakan komputer. HASIL Penelitian ini terdiri 85 subjek dengan median usia 50 (19-68) tahun dan laki-laki lebih banyak daripada perempuan (55,3% vs 44,7%). Disfungsi tiroid pada 16 subjek (18,8%), dan kasus hyperthyroid lebih banyak daripada hypothyroid (12,9% vs 5,9%). Subjek dengan euthyroid, hyperthyroid dan hypothyroid didapatkan rerata usia 49 (19-68); 58 (38-66); dan 50 (21-60) tahun (berurutan). Subjek dengan autoimmune dan non autoimmune thyroid sebanyak 12 (14%) vs 73 (86%) orang. Keseluruhan subjek didapatkan hasil RT-PCR SARS CoV-2 serum negatif (100%). SIMPULAN Diantara subjek dengan thyroid dysfunction didapatkan gangguan terbanyak yaitu hyperthyroid, dengan prevalensi autoimmune sebanyak 14% dan tidak didapatkan bukti transmisi virus SARS CoV-2 melalui darah. Perlu dilakukan skrining autoimmune thyroid pada pasien COVID-19.
Serum Angiopoeitin Like-4 As An Early Detection Marker Of Diabetic Kidney Disease Habsari, Pusparini; Ariningrum, Dian; Shofiyah, Laily
Eduvest - Journal of Universal Studies Vol. 4 No. 6 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i6.1459

Abstract

Diabetic kidney disease (DKD) is a long-term complication of diabetes mellitus (DM). The gold standard for diagnosis of DKD is kidney biopsy, but it is difficult to perform. Several clinical conditions have found an association between higher ANGPTL4 plasma levels in DKD. Methods: A total of 87 patients with Type 2 DM were analysed using an observational analytic method with a cross-sectional design. The study subjects were divided into DKD and non DKD groups, then serum ANGPTL4 was measured using the sandwich ELISA method. Furthermore, ANGPTL index cutoff was determined. Several other variables including glycemic control, duration of DM, history of hypertension, and dyslipidemia were analysed for their association with DKD and non DKD groups. The study continued by conducting multivariate analysis with logistic regression. Results: A total of 23 (26.4%) subjects were classified as DKD and 64 (73.6%) subjects as non DKD. ANGPTL cutoff determination of 16.64 ng/mL had a sensitivity and specificity of 87% and 51.6%, respectively. Bivariate analysis showed glycaemic control, duration of DM, and serum ANGPTL4 (p=0.044; p=0.009; p=0.014) were associated with the incidence of DKD. Multivariate analysis showed that serum ANGPTL4 with a cutoff of >16.64 ng/mL could be used as an independent predictor of DKD incidence with an adjusted OR of 6.73 (95%CI= 1.79-25.30; p=0.005). Conclusion: serum ANGPTL4 is an independent predictor of DKD. Suggestion: Urine sampling for UACR examination twice, periodic examination of serum ANGPTL4 levels to assess the progressiveness of DKD.
Co-Authors Eka Rezkita, Bastomy Fitriastuti, Avanti Habsari, Pusparini Immakulata Diah Pramudianti, Maria Pramudianti, M I D Pramudianti, M I Diah Putri, Desi Puspa Ratnani, Daniela Senaputra , Mas Aditya Shofiyah, Laily Sidharta, B. Rina Aninda Sinambela, Josua TH Sulistyantoko, Damar