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All Journal Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL BIOLOGI PAPUA
Yabansabra, Yuliana Rut
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Materials Science & Nanotechnology

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Phytochemical and Pharmacological Review of Arcangelisia flava (L.) Merr: Insights into Its Bioactive Compounds and Therapeutic Potential Yabansabra, Yuliana Rut; Bowaire, Anike; Simaremare, Eva S.; Yaam, Demas R.; Tiris, Aira; Nadeak, Erpina S.M.
Jurnal Biologi Papua Vol 17 No 1 (2025)
Publisher : Jurusan Biologi FMIPA Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31957/jbp.4508

Abstract

Arcangelisia flava (L.) Merr., commonly known as kayu kuning, is a medicinal plant traditionally used in Southeast Asian medicine. Various studies have identified bioactive compounds such as furanoditerpenes, alkaloids, flavonoids, tannins, and phenolic compounds that contribute to its pharmacological activities, including antimicrobial, antioxidant, and antidiabetic effects. Despite the growing body of research on its pharmacological potential, the mechanisms of action of these bioactive constituents remain inadequately understood, and clinical evidence supporting its use in modern therapy is still limited. This systematic review compiles data from diverse scientific sources, focusing on the phytochemical composition, extraction methods, pharmacological activities, and comparisons with conventional pharmaceutical agents. The analysis revealed that A. flava contains various bioactive constituents responsible for its therapeutic effects. Furanoditerpenes demonstrate antimicrobial and antifungal activity, while alkaloids and phenolic compounds exhibit significant antioxidant and antidiabetic properties. Extraction techniques varied across studies, affecting the efficiency of bioactive compound isolation. Comparisons with standard pharmaceuticals suggest that A. flava extracts exhibit comparable efficacy in several pharmacological domains. These findings indicate that A. flava holds considerable promise as a natural therapeutic agent. However, further investigations are needed to clarify its pharmacological mechanisms through pharmacokinetic and pharmacodynamic studies, as well as clinical trials to confirm its safety and effectiveness in human applications. The integration of modern technological approaches such as metabolomics and bioinformatics could facilitate the identification, standardization, and development of phytopharmaceutical products derived from A. flava, thereby advancing its potential use in evidence-based medicine.
The Pengembangan Sediaan Farmasi Berbasis Herbal dari Dondai-Sentani, Papua Tahir, Rifky Pratama Syachputra; Maharani, Musdalifa Putri; Astuti, Wahyu Dwi; Burhanuddin, Rahmawati; Samaa, Merry Christiani; Siregar, Enjelina; Mokay, Prilli Anastasia; Paskaline, Apriani Cissyvana; Kafiar, Wendy; Eybe, Warry Johannest; Sawor, Teresa; Rahmani, Anisa Zahra; Yabansabra, Yuliana Rut; Simaremare, Eva Susanty
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 2 (2024): Agrokreatif Jurnal Ilmiah Pengabdian Kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.10.2.240-249

Abstract

Dondai Village, Waibu District, has several potential medicinal plants that can improve the community's economy by creating new products. Service activities through the KKN/Village Wira program aim to assist and counsel the community, especially those who want to become entrepreneurs. The implementation methods are tutorials and discussions, socialization, demonstrations or training, mentoring, evaluation, and monitoring. The results obtained show that there are five products from Dondai, namely betel leaves as aromatherapy candles, putri malu leave as paper soap or betel leaf paper soap, Chinese ketepeng leaves as soap or body wash, lantana leaves as an antiseptic or hand-sanitizer, and miana lotion. As many as 97% of people are interested in making products, and 95% are interested in marketing products. It is hoped that this program can develop creativity, community knowledge, and insight to innovate to improve the standard of living.
Co-Authors Bowaire, Anike Burhanuddin, Rahmawati Erpina Santi Meliana Nadeak Eybe, Warry Johannest Kafiar, Wendy Maharani, Musdalifa Putri Mokay, Prilli Anastasia Paskaline, Apriani Cissyvana Rahmani, Anisa Zahra Samaa, Merry Christiani Sawor, Teresa Siregar, Enjelina Tahir, Rifky Pratama Syachputra Tiris, Aira Wahyu Dwi Astuti Yaam, Demas R.