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All Journal Dentino: Jurnal Kedokteran Gigi
Krishnawan Firdaus, I Wayan Arya
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Dentistry

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TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RATS LIVER (Rattus norvegicus) Putra Ramadhani, Krisna Erlangga; Krishnawan Firdaus, I Wayan Arya; Wasiaturrahmah, Yusrinie; Aspriyanto, Didit; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22200

Abstract

Background: Kelakai leaf extract can be used as an alternative wound healing medicine because it contains flavonoid and phenolic compounds that act as antioxidants. Before use, herbal plants must ensure the level of safety that can be obtained from toxicity tests, one of which is in vivo which can be seen from their effect on the liver of Wistar rats based on SGOT and SGPT levels. Purpose: Proving there is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, and 3,000 mg/kgBW on the liver of Wistar rats based on SGOT and SGPT levels. Method: Pure laboratory experimental research with posttest-only design with control group design, consisting of 16 wistar rats divided into 4 groups with 1 negative control group given distilled water and 3 treatment groups given doses of kelakai leaf extract 2,000, 2,500 and 3,000 mg/kgBW twice a day every morning and evening for 28 days. Results: SGOT and SGPT levels after 28 days were still in the normal range. SGOT levels in treatment groups 1, 2, and 3 were 61.244 U/L, 58.953 U/L, and 53.536 U/L. SGPT levels in treatment groups 1, 2 and 3 were 25.137 U/L, 23.331 U/L, and 21.179 U/L. Based on statistical tests, there were significant differences in all treatment groups. Conclusion: There is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, 3,000 mg/kgBW orally for 28 days on the liver of Wistar rats based on SGOT and SGPT levels.
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT BASED ON KIDNEY HISTOPATHOLOGY OF BLEEDING AND NECROSIS Salsabila, Namira Fathya; Krishnawan Firdaus, I Wayan Arya; Wasiaturrahmah, Yusrinie; Putri Utami, Juliyatin; Setiawan, Bambang
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22201

Abstract

Background: Ironwood plant (Eusideroxylon zwageri) can potentially be an herbal medicine that accelerates wound healing because of the antioxidant compounds contained in it. The dominant compounds contained in ironwood bark are flavonoids 30.48 mgCE/g, phenolics 31.28 mgCE/g, and proanthocyanidins 183.3 mgCE/g. Before used as an herbal medicine, it is necessary to do an acute toxicity test on ironwood bark at doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW to consider the right dose. Acute toxicity tests can be seen using histopathological appearance in the kidney based on bleeding and necrosis. Purpose: Determine the toxic effects of giving Eusideroxylon zwageri doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the kidneys of Wistar rats (Rattus norvegicus) based on bleeding and necrosis in histopathological appearance. Method: Research is true experimental and  posttest-only with control design. The study was divided into a control group given aquades and a treatment group given ironbark extract dose of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW as much as 1 ml given 2 times a day orally for 14 days. Results: The percentage of histopathological appearances of bleeding and necrosis score is 1 or mild. Analysis of bleeding and necrosis did not show significant differences of ironwood bark extract doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW. Conclusion: There were no toxic effects of ironwood bark extract doses  of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the kidney organs of wistar rats based on bleeding and necrosis in histopathological appearances.
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT ON LIVER HISTOPATHOLOGY PARENCHYMATOUS DEGENERATION AND FATTY DEGENERATION A'idah, Nurul; Aspriyanto, Didit; Krishnawan Firdaus, I Wayan Arya; Sukmana, Bayu Indra; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22203

Abstract

Background: Ironwood bark extract can be developed into an alternative herbal medicine for wound healing because it contains phenolics, flavonoids, and proanthocyanidins which can act as an antioxidant. Before being used as an herbal medicine, it is necessary to ensure its safety through an toxicity test. Purpose: To find out whether there is no toxic effect on the orally administration of ironwood bark extract (Eusideroxylon zwageri) at the doses of 1,250 mg/kgBW, 2,750 mg/kgBW, and 4,750 mg/kgBW to the livers of Wistar rats (Rattus norvegicus) based on histopathological appearance of parenchymatous degeneration and fatty degeneration. Methods: This research is purely experimental with a posttest only with control design. The sample in this study were 16 Wistar rats which were divided into  4 groups, namely the control group which was only  administered distilled water and the treatment groups P1, P2, P3 which were administered ironwood bark extrac at the doses of 1,250 mg/kg BW, 2,750 mg/kg BW, and 4,750 mg/kgBW of 2x1 ml every 24 hours for 14 days. Results: The average percentages of histopathological appearance of parenchymatous degeneration and fatty degeneration in the K, P1, P2, and P3 groups showed a score of 0 which was categorized as normal. Data analysis showed that there were no significant differences between groups P1, P2, and P3 with the control group. Conclusion: Ironwood bark extract doses of 1,250 mg/kg BW, 2,750 mg/kg BW, and 4,750 mg/kg BW had no toxic effect on the liver of Wistar rats based on histopathological appearance of parenchymatous degeneration and fatty degeneration.
Co-Authors A'idah, Nurul Aspriyanto, Didit Bambang Setiawan Bayu Indra Sukmana Putra Ramadhani, Krisna Erlangga Salsabila, Namira Fathya Utami, Juliyatin Putri Wydiamala, Erida Yusrinie Wasiaturrahmah