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ANTIBACTERIAL EFFECTIVENESS OF KECAPI SENTUL EXTRACT (SANDORICUM KOETJAPE MERR.) AGAINST STREPTOCOCCUS MUTANS Adhimas Rilo Pambudi; Yusrinie Wasiaturrahmah; Didit Aspriyanto
ODONTO : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.2.1-10

Abstract

ABSTRACTBackground: One of the causing dental caries is a microorganism, namely Streptococcus mutans. Kecapi sentul leaves extract (Sandoricum koetjape Merr.) contain alkaloid, flavonoid, saponin, steroid, phenol, and triterpenoid which have antibacterial properties on the inhibition Streptococcus mutans which has the potential to prevent dental caries.Method: This research uses a laboratory experimental design with a post-test control group only design, using seven treatment groups, namely kecapi sentul leaves extract with the concentration of group 30%, 40%, 50%, 60%, 70%, Chlorhexidine gluconate 0.2% as positive control and aquadest as negative control were repeated 4 times. Result: Non parametric test Kruskal Wallis and Post Hoc Mann Whitney methods showed that each treatment group was significantly different in the diameter of the formed inhibition zone. The mean diameter of the inhibition zone with a concentration of 30% was 9.1 mm, 40% was 13.3 mm, 50% was 17.13 mm, 60% was 18.65 mm and 70% was 21.05 mm.Conclusion: Kecapi sentul leaves extract (Sandoricum koetjape Merr.) with the concentration of group 30%, 40%, 50%, 60% and 70% have antibacterial potential against the growth of Streptococcus mutans.
Hydroxyl Radical Scavenging Activity of Stachytarpheta jamaecensis Root Extract using In Vitro Deoxyribose Degradation Assay Juliyatin Putri Utami; Yusrinie Wasiaturrahmah; Deby Kania Tri Putri
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.61746

Abstract

Use and demand of traditional medicinal plants currently growing in the direction that research in traditional medicines have also increased. One of the plants that is efficacious as a medicine is S. jamaecensis. This plant is usually used by people as a traditional medicine to treat various diseases. This study aims to determine the antioxidant activity of porterweed root. Antioxidant activity assays performed using hydroxyl radical scavenger that begins with the extraction by maceration. Dry roots of S. jamaecensis  (250 g) was soaked with ethanol 96% for 3x24 hours at room temperature. The liquid extract obtained is evaporated by rotary evaporator and waterbath till viscous extracts is obtained. Then to extract performed phytochemical screening by quantitative and qualitative method. The antioxidant test was carried out using the hydroxyl radical scavenger method. The extract concentrations were varied, namely 125, 250, 500 and 1000 ppm. The data obtained was performed one-way ANOVA test. The results of the phytochemical screening showed the extract contains flavonoids, alcaloids, saponins, phenols and tannins. The results obtained were significant values from the antioxidant test with the antiradical scavenger method, the largest average value of root extract was 60.606% at a concentration of 1000 ppm. The results of spectrophotometric measurements showed that the extract has IC50 was 683.5294 µg/ml, while vitamin C has  IC50 lower value (251.700 µg/ml). Q
ANTIFUNGAL ACTIVITIES OF MAULI BANANA STEM AND BASIL LEAVES EXTRACT MIXTURE AGAINST Candida albicans Nor Kamalia; Maharani Laillyza Apriasari; Yusrinie Wasiaturrahmah
Dentino : Jurnal Kedokteran Gigi Vol 5, No 2 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i2.8948

Abstract

ABSTRACTBackground: Mauli banana stem and basil leaves are natural ingredients that have the potential to be used as a treatment for Candida albicans infections. The methanol extract of mauli banana stem with 25% concentration is merely fungistatic which is still not capable to induce fungicidal effect, while the 100% concentration is known to be less effective than 0.2% chlorhexidine gluconate. Adding basil leaves extract to mauli banana stem extract is expected to increase antifungal activities against Candida albicans. Purpose: to analyze the antifungal activity of mauli banana stem and basil leaves extract mixture with concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% against Candida albicans by dilution method. Method: This research used a true experimental method with a pretest–posttest control group design consisting of 11 treatments to obtain Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Result: The 10% concentration was identified as the Minimum Inhibitory Concentration (MIC), and no concentration could be classified as the Minimum Bactericidal Concentration (MBC) because all treatment group still exhibited Candida albicans growth on the SDA medium. Conclusion: Mauli banana stem and basil leaves extract mixture has an MIC value of 10% and does not demonstrate any value for the MBC. Keywords: Basil leaf, Candida albicans, Mauli banana stem, MBC, MIC
ANTIBACTERIAL EFFECT OF MAULI BANANA STEM EXTRACT, BASIL LEAF EXTRACT, AND THEIR COMBINATION ON Staphylococcus aureus Almadina Latanza; Maharani Laillyza Apriasari; Yusrinie Wasiaturrahmah
Dentino : Jurnal Kedokteran Gigi Vol 5, No 2 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i2.8953

Abstract

ABSTRACTIntroduction: Mauli banana stem and basil leaf extracts have an antibacterial effect on Staphylococcus aureus because they contain flavonoid, saponin, alkaloid, tannin, and eugenol. 1% povidone iodine is commonly used as an antiseptic and gargle for recurrent aphthous stomatitis caused by Staphylococcus aureus. Prolonged use of 1% povidone iodine is notable to possess adverse effects. Objective: To prove the antibacterial effect of mauli banana stem extract with 25% concentration, basil leaf extract with 12.5% concentration, and mauli banana stem and basil leaf combination extract with 25%, 50%, and 75% concentration on Staphylococcus aureus and compared to 1% povidone iodine. Methods: This study was applying the true experimental design with post-test only and control group design which consisted of 6 treatments. Group I was given with Mauli banana stem extract with 25% concentration, group II with basil leaf extract with 12.5% concentration, group III, IV, and IV with mauli banana stem and basil leaf combination extract with 25%, 50%, and 70% concentration, respectively. Meanwhile, group VI was given with 1% povidone iodine as a positive control. Each treatment had 4 times repetition. Antibacterial effectivity was assessed from the inhibition zone measurement of Staphylococcus aureus growth using the diffusion method. Results: This study revealed that the mean inhibition zone formed in group I was 6-6.2 mm, group II was 6-6.2 mm, group III was 6-6.9 mm, group IV was 7.6-8 mm, group V was 8-8.5 mm, and group VI was 10.6-11.8 mm. Conclusion: The antibacterial efficacy of mauli banana stem extract at 25% concentration, basil leaf extract at 12.5% concentration, mauli banana and basil leaf combination extract at 25%, 50%, and 75% concentration on Staphylococcus aureus has been proven but not equal to 1% povidone iodine’s efficacy. Keywords: Basil leaf extract, Diffusion method, Inhibition zone, Mauli banana stem extract, Staphylococcus aureus,.
EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KASTURI (Mangifera casturi) TERHADAP PERTUMBUHAN BAKTERI Aggregatibacter actinomycetemcomitans Luthfi Ridhwana; Fransiska Uli Arta Puspitasari; Yusrinie Wasiaturrahmah
Dentin Vol 4, No 2 (2020)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBackground: Prevalence of periodontitis in Indonesia is 74.1%, and periodontitis type that causes mayor periodontal damage with minimal microbiological factors is Aggressive Periodontitis. Microbiological factor in aggressive periodontitis is Aggregatibacter actinomycetemcomitans which producing toxins which stimulate the immune response and tissue damage. Many researchers today discover new antibiotic ingredients with a minimal side effect such as Kasturi plant. Kasturi leaf extract contains triterpenoids, flavonoids, tannins, and phenolic, which have the antibacterial effect. Objective: To Identifying and analyzing the effectiveness of antibacterial effect on Kasturi leaves extract against Aggregatibacter Actinomcetemcomitans growth. Methods: This study used true experimental post-test only with control group design by broth and agar dilution method to determine Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The result data analyzed with Kruskal-Wallis and Mann Whitney Post hoc test. Results: MIC was found at 20 mg/ml concentration and MBC at 40 mg/ml concentration. Conclusion: Kasturi leaf extract was effective in inhibited and stopped Aggregatibacter actinomycetemcomitans growth.Keywords :  Aggregatibacter actinomycetemcomitans, Aggressive Periodontitis, Kasturi leaf extract (Mangifera casturi), MBC, MIC.ABSTRAKLatar Belakang: Prevalensi periodontitis di Indonesia sebesar 74,1% dan periodontitis yang menimbulkan kerusakan besar dengan faktor mikrobiologi yang minimal yaitu periodontitis agresif. Faktor mikrobiologi berupa bakteri Aggregatibacter actinomycetemcomitans yang memproduksi toksin penyebab gangguan respons imun dan kerusakan jaringan. Penelitian mengenai bahan antibiotik dengan efek samping minimal telah banyak dilakukan salah satunya dengan tumbuhan Kasturi. Daun Kasturi mengandung senyawa berupa triterpenoid, flavonoid, tanin, dan fenol yang bersifat antibakteri. Tujuan: Mengetahui dan menganalisis efektivitas antibakteri ekstrak daun kasturi terhadap pertumbuhan bakteri Aggregatibacter actinomycetemcomitans. Metode: True experimental dengan desain post test only with control group dan mempunyai 6 kelompok perlakuan dengan 6 kali pengulangan. Penelitian ini menggunakan metode dilusi cair dan padat untuk mengetahui nilai Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM). Analisis data menggunakan metode Kruskal Wallis dan uji Post hoc Mann Whitney. Hasil: KHM pada ekstrak daun kasturi terdapat pada konsentrasi 20 mg/ml dan KBM pada konsentrasi 40 mg/ml. Kesimpulan: Ekstrak daun kasturi efektif dalam menghambat dan menghentikan pertumbuhan bakteri Aggregatibacter actinomycetemcomitans.Kata kunci :  Aggregatibacter actinomycetemcomitans, Ekstak Daun Kasturi (Mangifera casturi), KBM, KHM, Periodontitis Agresif,
PROFIL PENGGUNAAN OBAT PADA PASIEN COVID-19 DI SALAH SATU RUMAH SAKIT DI BANJARMASIN Yusrinie Wasiaturrahmah; Aditya Maulana Perdana Putra; Nahdha Nahdha; Nahdiya Rahmah
Jurnal Insan Farmasi Indonesia Vol 5 No 1 (2022): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v5i1.917

Abstract

Coronavirus 19, Knowing as COVID-19, is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 treatment is still limited to supportive and oxygen therapy. The use of drugs is on the complaints felt by patients and comorbidities. This study aims to look at drug use profiles in COVID-19 patients. This research was included in descriptive research with a retrospective cross-sectional design. This research data was the entire prescription sheet and medical records of COVID-19 patients for March-August 2020 that meet the inclusion criteria. The result from collecting COVID-19 patient data for March-August 2020 obtained 114 medical records that met the criteria for research inclusion. Research Result: Characteristics of study subjects of the male sex are more infected with COVID-19. The age range with the highest number of COVID-19 patients was 46-55 years. Treatment profiles often used in COVID-19 patients are Supplements and Vitamins for 6538 prescriptions and Antibiotics for 2813 prescriptions. The most prescribed supplements and vitamins are Vitamin C, Lakto B, Zinc, and Vitamin C. The most prescribed antibiotics are Azithromycin, Meropenem, and Levofloxacin. The conclusion obtained in this study is that Supplements and vitamins, and Antibiotics are the most prescribed drug class.
PROFIL KEYAKINAN SAKIT PADA PASIEN HIPERTENSI DI PUSKESMAS Yusrinie Wasiaturrahmah
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 2 (2020): March 2020
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.207 KB)

Abstract

Hipertensi atau peningkatan tekanan darah dimana tekanan darah sistolik 140 mmHg dan atau tekanan darah diastolik 90 mmHg dapat menyebabkan komplikasi yang lebih berbahaya. Hipertensi memerlukan pengobatan jangka panjang, sehingga kepatuhan pasien dalam pengobatan merupakan faktor penting untuk tercapainya target terapi. Salah satu faktor yang mempengaruhi kepatuhan pengobatan adalah keyakinan sakit (illness beliefatau illness perceptions) pasien terhadap penyakitnya. Keyakinan sakit mempengaruhi perilaku seseorang untuk mengambil atau tidak mengambil pengobatan. Tujuan penelitian untuk memberikan profile atau gambaran keyakinan sakit pasien hipertensi terhadap penyakitnya. Penelitian ini merupakan penelitian deskriptif dengan menggunakan Brief Illness Perception Questionnaire (BIPQ) untuk mengukur keyakinan sakit pasien hipertensi pada 100 responden. Hasil penelitian menunjukkan rata-rata skor total BIPQ pada penelitian ini sebesar 38,56(±7,389) yang berarti responden memiliki persepsi atau pandangan bahwa hipertensi merupakan penyakit yang tidak mengancam bagi mereka. Pasien sebagian besar mengurutkan bahwa penyebab hipertensi disebabkan oleh gaya hidup, stress dan keturunan (27%).
FORMULASI DAN UJI SIFAT FISIK GEL HAND SANITIZER DARI EKSTRAK DAUN SALAM (Syzygium polyanthum) Yusrinie Wasiaturrahmah; Raudhatul Jannah
BORNEO JOURNAL OF PHARMASCIENTECH Vol 2 No 2 (2018): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Gel hand sanitizer telah banyak digunakan sebagai jalan keluar untuk menjaga kesehatan dan kebersihan tangan yang praktis dan mudah dibawa. Umumnya gel hand sanitizer mengandung senyawa alkohol sebagai antiseptik untuk membunuh bakteri, tetapi penggunaan gel antiseptik yang mengandung alkohol dalam jangka panjang dapat menimbulkan iritasi. Oleh karena itu, diperlukan bahan alternatif alami yang ramah di kulit dan tidak mengiritasi kulit, salah satu tanaman yang memiliki daya antibakteri adalah daun salam (Syzygium polyanthum). Tujuan penelitian ini untuk mengetahui formulasi dan uji sifat fisik hand sanitizer dari ekstrak daun salam (Syzygium polyanthum). Penelitian ini merupakan penelitian eksperimen dengan data hasil penelitian disajikan secara deskriptif. Gel dibuat dalam tiga formula dengan konsentrasi karbopol yang berbeda yaitu 0,2%, 0,5%, 0,8%. Evaluasi sifat fisik gel yang dilakukan meliputi uji organoleptik, homogenitas, daya sebar, daya lekat, pH, dan viskositas. Hasil evaluasi menunjukkan formula 1 (karbopol 0,2%) dan formula 2 (karbopol 0,5%) memenuhi semua syarat pada evaluasi sifat fisik gel yang meliputi uji organoleptik, homogenitas, daya sebar, daya lekat, pH, dan viskositas. Sedangkan formula 3 (karbopol 0,8%) tidak memenuhi uji sifat fisik yaitu uji daya sebar
POTENSI INTERAKSI OBAT PADA PASIEN COVID-19 DI SALAH SATU RUMAH SAKIT DI PROVINSI KALIMANTAN SELATAN Aditya Maulana Perdana Putra; Yusrinie Wasiaturrahmah; Nahdiya Rahmah; Nahdha
Majalah Farmasi dan Farmakologi Vol. 25 No. 3 (2021): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v25i3.18238

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Coronavirus 2019 (COVID-19) adalah penyakit menular yang disebabkan oleh virus corona baru yang pertama kali diidentifikasi pada Desember 2019. Hingga saat penelitian ini dilakukan, belum ditemukan obat yang spesifik untuk penyakit COVID-19 sehingga pengobatan masih bersifat suportif dan simptomatik. Hal ini mengakibatkan pasien mendapatkan banyak obat/polifarmasi yang berpotensi berinteraksi. Tujuan dari penelitian ini untuk menganalisis potensi interaksi obat pada pasien Covid-19. Jenis penelitian ini adalah observasional retrospektif dengan metode analisis secara deskriptif. Penelitian dilakukan dengan cara mengumpulkan data dari Pusat Data Elektronik dan Rekam Medis pasien Covid-19 periode maret-agustus 2020. Pemeriksaan interaksi obat dilakukan melalui website Micromedex. Berdasarkan data yang diperoleh dari 114 rekam medis pasien Covid-19 didapatkan sebanyak 231 potensi interaksi obat. Untuk Kategori keparahan interaksi obat Minor (17 kasus), Moderate (151 kasus), Mayor (765 kasus) dan Contraindicated (20 kasus). Sementara untuk kategori onset interaksi obat Delayed (85 kasus), Rapid (71 kasus) dan Not Specified (797 kasus). Lima interaksi obat terbesar yaitu Azitromisin – Hidroksikloroquin (80 kasus), Azitromisin – Levofloxacin (62 kasus), Hidroksikloroquin – Levofloxacin (56 kasus), Aztromisin – Lovinapir dan Ritonavir (26 kasus) dan Azitromisin Moxifloxacilin (26 kasus).
FORMULASI DAN UJI STABLITAS FISIK GEL EKSTRAK BATANG PISANG MAULI (Musa acuminata) Maman Diki Wahyudi; Fitri Syahrina; Amy Nindia Carabelly; Dewi Puspitasari; Yusrinie Wasiaturrahmah
Dentin Vol 6, No 3 (2022)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v6i3.6824

Abstract

ABSTRACTBackground: Mauli banana is a typical South Kalimantan banana. Mauli banana stems contain active substances, such as tannins, saponins, alkaloids, flavonoids, and lycopene. Several studies have shown that Mauli banana stem extract (BPM) has anti-inflammatory, antibacterial properties and reduces the viability of Streptococcus Mutans and Lactobacillus acidophilus in the formation of dual-species biofilms. Gel formulations must have physical stability to ensure the physical stability of the gel, gel quality, and meet the criteria parameters during storage. The physical stability test of the gel was investigated for 16 days at room temperature. Gel stability tests were homogeneity, dispersion, and pH tests. Objectives: to determine the formulation and physical stability including homogeneity, dispersibility, and pH test of BPM gel 25%; 37.5%; 50%, and 62.5%. Methods: Mauli banana stems were obtained from SMK-PP Banjarbaru, tested for determination, made extracts, and made BPM gel by adding propylene glycol, glycerin, Na-CMC, nipagin, and aquadest, then testing for homogeneity, spreadability, and pH. Results: BPM gel showed homogeneous results until the 16th day with even distribution of color and no coarse grains. The BPM gel dispersion test met the criteria of 3cm-5cm until the 16th day with the results of the BPM gel dispersive power being 3.7cm-4.6cm. In the pH test, the BPM gel also met the criteria until the 16th day with a physiological pH of the oral cavity of 5.5-7.9. Conclusion: BPM gel with a concentration of 25%; 37.5%; 50% and 62.5% have results that match the criteria based on homogeneity, dispersion, and pH. Keyword: Gel, Mauli Banana Stem Extract, Physical Stability ABSTRAK Latar Belakang: Pisang mauli merupakan pisang khas Kalimantan Selatan. Batang pisang mauli mengandung zat aktif, seperti tanin, saponin, alkaloid, flavonoid dan likopen. Beberapa penelitian ekstrak batang pisang mauli (BPM) memiliki khasiat sebagai antiinflamasi, antibakteri dan menurunkan viabilitas Streptococcus Mutans serta Lactobacillus achidophilus dalam pembentukan dual-spesisies biofilm. Pembuatan formulasi sebuah gel harus memiliki stabilitas fisik agar menjamin kestabilan fisik gel, kualitas gel dan memenuhi parameter kriteria selama penyimpanan. Uji stabilitas fisik gel diteliti selama 16 hari pada suhu ruangan. Pengujian stabilitas gel yang dilakukan ialah uji homogenitas, uji daya sebar dan uji pH. Tujuan: Mengetahui formulasi dan stabilitas fisik meliputi uji homogenitas, daya sebar dan pH gel ekstrak batang pisang mauli (Musa acuminata) konsentrasi 25%; 37,5%; 50% dan 62,5%. Metode: Batang pisang mauli diperoleh dari SMK-PP Banjarbaru, diuji determinasi, dilakukan pembuatan ekstrak dan pembuatan gel BPM dengan menambahkan propilen glikol, glycerin, Na-CMC, nipagin dan aquadest, selanjutnya gel dilakukan uji homogenitas, daya sebar dan pH. Hasil: Uji homogenitas menunjukan gel BPM semua konsentrasi homogen sampai hari ke-16 dengan meratanya penyebaran warna dan tidak terdapat butiran kasar. Uji daya sebar gel BPM memenuhi kriteria 3cm-5cm sampai hari ke-16 dengan hasil range daya sebar gel BPM 3,7cm-4,6cm. Pada uji pH gel BPM seluruh konsentrasi juga memenuhi kriteria sampai hari ke-16 dengan pH fisiologis rongga mulut 5,5-7,9. Kesimpulan: Gel ekstrak batang pisang mauli konsentrasi 25%; 37,5%; 50% dan 62,5% memiliki hasil yang sesuai dengan kriteria berdasarkan homogenitas, daya sebar dan pH. Kata kunci : Ekstrak Pisang Mauli, Gel, Stabilitas Fisik