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Verma, Renuka
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Medicine & Pharmacology

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A review of wound healing activity on different wound models Verma, Renuka; Gupta, Pushpa Prasad; Satapathy, Trilochan; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 7 No 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.187 KB) | DOI: 10.18231/2348-0335.2018.0013

Abstract

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin.which may lead to disturbance of skin anatomical structure and their function. The normal wounds are starts to healing immediately after an injury. Healing process are involved a series of coordinated events (inflammatory response, proliferation, maturation phase).  Wound healing remains a challenging clinical problem therefore correct and efficient wound management is essential. The screening models are important biological tools to understand basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture And the  in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model, Skin wound induction.the aim of this review is detailed study on different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity.
A review of wound healing activity on different wound models Verma, Renuka; Gupta, Pushpa Prasad; Satapathy, Trilochan; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 7 No. 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.187 KB) | DOI: 10.18231/2348-0335.2018.0013

Abstract

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin. This may lead to disturbance of skin anatomical structure and their function. The normal wounds start to heal immediately after an injury. Normal healing process involved: inflammatory phase, proliferation phase and maturation phase. Now a day wound healing is a challenging clinical problem. So, necessity of effective wound management is required. The various screening models play important role to understand the basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. Ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture and the in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model.The aim of this review article is detailed study of different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity.
Modulation of mesalamine release from enteric-coated matrix tablets using natural polysaccharides for localized colonic delivery Sahu, Shilpa; Choudhury, Prasanta Kumar; Pasa, Gourishyam; Murthy, Padala Narasimha; Sahu, Poonam; Verma, Renuka
Journal of Applied Pharmaceutical Research Vol. 12 No. 2 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.2.93.108

Abstract

Background: Inflammatory bowel diseases (IBD) require effective colon-targeted drug delivery for improved therapeutic efficacy and minimized systemic side effects. Objectives: The objective of this research was to develop and evaluate novel colon-targeted matrix tablet formulations of mesalamine (5-aminosalicylic acid) for the treatment of IBD. Materials and Methods: Mesalamine matrix tablets were prepared by wet granulation technique using pH-sensitive polymers (HPMC K4M) and biodegradable natural polysaccharides (pectin, chitosan, and guar gum). Tablets were characterized for physicochemical properties, drug content, and in vitro drug release. Compatibility studies using FTIR and DSC confirmed no interaction between mesalamine and polymers. The optimized formulations were enteric-coated with Eudragit S100 and ethyl cellulose. Drug release kinetics and stability studies were conducted. Results and Discussion: The uncoated formulations (M3, M6, M7) showed adequate protection against drug release in simulated gastric (0-2 h) and intestinal (2-5 h) fluids. The enteric-coated formulations (ME3, ME6, ME7) exhibited a lag time of around 2 hours and restricted drug release (<5%) in simulated gastric and intestinal fluids up to 5 hours. However, in simulated colonic fluid (pH 6.8) containing 4% rat cecal contents, these formulations showed enhanced drug release (71-83% in 12 h) due to biodegradation of polymeric matrices by colonic enzymes. Drug release kinetics indicated anomalous transport or super case-II transport mechanisms. Stability studies at 40°C/75% RH for 3 months revealed no significant changes. Conclusion: The developed colon-targeted mesalamine matrix tablets demonstrated the potential to protect the drug from release in the upper GIT while facilitating targeted drug delivery to the colon, which could improve therapeutic efficacy and minimize systemic side effects in the treatment of IBD.
Co-Authors Amit Roy, Amit Choudhury, Prasanta Kumar Gupta, Pushpa Prasad Murthy, Padala Narasimha Pasa, Gourishyam Sahu, Poonam Sahu, Shilpa Trilochan Satapathy, Trilochan