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Gupta, Pushpa Prasad
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Medicine & Pharmacology

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A review of wound healing activity on different wound models Verma, Renuka; Gupta, Pushpa Prasad; Satapathy, Trilochan; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 7 No 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.187 KB) | DOI: 10.18231/2348-0335.2018.0013

Abstract

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin.which may lead to disturbance of skin anatomical structure and their function. The normal wounds are starts to healing immediately after an injury. Healing process are involved a series of coordinated events (inflammatory response, proliferation, maturation phase).  Wound healing remains a challenging clinical problem therefore correct and efficient wound management is essential. The screening models are important biological tools to understand basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture And the  in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model, Skin wound induction.the aim of this review is detailed study on different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity.
A review of wound healing activity on different wound models Verma, Renuka; Gupta, Pushpa Prasad; Satapathy, Trilochan; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 7 No. 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.187 KB) | DOI: 10.18231/2348-0335.2018.0013

Abstract

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin. This may lead to disturbance of skin anatomical structure and their function. The normal wounds start to heal immediately after an injury. Normal healing process involved: inflammatory phase, proliferation phase and maturation phase. Now a day wound healing is a challenging clinical problem. So, necessity of effective wound management is required. The various screening models play important role to understand the basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. Ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture and the in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model.The aim of this review article is detailed study of different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity.
Co-Authors Amit Roy, Amit Trilochan Satapathy, Trilochan Verma, Renuka