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All Journal Jurnal Teknologi Industri Pertanian Makara Journal of Science Warta Pusat Penelitian Kelapa Sawit
Kresnawaty, Irma
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Engineering Industrial & Manufacturing Engineering

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UJI AKTIVITAS ANTIOKSIDAN DAN BIOTRANSFORMASI EKSTRAK ETANOL DAN HEKSANA DAUN KELAPA SAWIT UNTUK SUPLEMEN KESEHATAN Kresnawaty, Irma; Permatasari, Galuh Wening; Widodo, Widodo; Santoso, Djoko
Jurnal Teknologi Industri Pertanian Vol. 33 No. 3 (2023): Jurnal Teknologi Industri Pertanian
Publisher : Department of Agroindustrial Technology, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24961/j.tek.ind.pert.2023.33.3.207

Abstract

Oil palm fronds and leaves are wastes of oil palm plantations which are abundantly available in Indonesia and contain polyphenolic compounds which have high economic potential and health value. However, the potential for polyphenols from oil palm leaf extract (OPLE), which has antioxidant activity, has not been utilized optimally until now. In this research, an antioxidant food supplement from OPLE which is rich in polyphenolic compounds was developed. OPLE was prepared using ethanol as a solvent and concentrated by vacuum evaporation, then separated by liquid-liquid column chromatography and identified by LC-MS. The total phenolic yield of the ethanol extract of palm leaves contained was higher phenolic content than the hexane extract, while the phenolic content and antioxidant content of the oldest leaf were higher than the 17th leaf. Separation of the active antioxidant ingredients was carried out by liquid-liquid column chromatography with chloroform eluent: methanol = 4: 1 v/v which is expected to separate the active compounds. The content of flavonoids contained in this fraction is 6-Methoxy-2-[2-(3'-methoxyphenyl) ethyl] chromone. Biotransformation using tannase enzyme produced the increase of flavonoid content and antioxidant of oil palm extracts. Keywords : antioxidant, biotransformation, immunomodulator, OPLE, supplement
PERKEMBANGAN TEKNOLOGI MEDIUM-CHAIN TRIGLYCERIDE DAN PELUANGNYA UNTUK MENINGKATKAN NILAI EKONOMI KELAPA SAWIT INDONESIA Putra, Ludwinardo; Kresnawaty, Irma; Fitriyah, Fauziatul
WARTA Pusat Penelitian Kelapa Sawit Vol. 30 No. 2 (2025): Warta Pusat Penelitian Kelapa Sawit
Publisher : Pusat Penelitian Kelapa Sawit

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/iopri.war.warta.v30i2.234

Abstract

Medium-chain Triglycerides (MCT) merupakan senyawa lemak fungsional yang semakin mendapat perhatian dalam industri pangan dan kesehatan global karena karakteristik metabolik dan fisiologisnya yang unggul. Dibandingkan trigliserida rantai panjang (LCT), MCT lebih cepat diserap dan digunakan tubuh sebagai sumber energi, sehingga diaplikasikan luas dalam diet ketogenik, nutrisi klinis, serta suplemen olahraga. Hingga saat ini, minyak kelapa menjadi sumber utama bahan baku MCT karena kandungan asam lemak rantai sedang (MCFA) yang tinggi, namun keterbatasan suplai dan harga yang tinggi membatasi skalabilitasnya secara global. Kajian ini mengulas potensi minyak inti sawit (PKO) sebagai bahan baku alternatif untuk produksi MCT berbasis kelapa sawit. Selain ketersediaannya yang tinggi di Indonesia (>5 juta ton/tahun), PKO memiliki kandungan MCFA signifikan, terutama asam laurat (C12), serta harga yang lebih kompetitif dibanding minyak kelapa. Dari sisi teknologi, berbagai pendekatan sintesis MCT telah dikembangkan, mulai dari reaksi kimiawi, enzimatik, hingga rekayasa molekuler berbasis mikroorganisme dan mikroalga. Beberapa penelitian juga menunjukkan potensi ekonomi sirkuler dengan memanfaatkan distilat PKO sebagai bahan baku bernilai tambah tinggi. Indonesia memiliki peluang strategis untuk menjadi produsen utama MCT global karena rantai pasok sawit yang terintegrasi, skala produksi besar, dan dukungan kebijakan hilirisasi nasional. Pengembangan teknologi produksi MCT berbasis PKO tidak hanya mendukung daya saing industri sawit, tetapi juga membuka peluang komersialisasi produk turunan sawit bernilai tinggi di sektor kesehatan global.
In Silico Target Identification for Antioxidant and Anti-inflammatory Activity of Oil Palm Leaves Extract after Biotransformation Process Permatasari, Galuh; Kresnawaty, Irma; Aksa, Annisa Aulia; Santoso, Djoko; Widodo, Widodo
Makara Journal of Science Vol. 29, No. 4
Publisher : UI Scholars Hub

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Abstract

Oil palm leaf extract (OPLE) contains abundant phenolic and flavonoid compounds with recognized antioxidant and anti-inflammatory potential; however, its pharmacological applications remain underexplored. This study aimed to optimize the enrichment process of OPLE and characterize its bioactive compounds using integrated in vitro and in silico approaches. The extraction was optimized by incorporating trichloroacetic acid and extending the incubation time to 48 h, resulting in significantly increased total phenolic content and antioxidant activity compared with the control. LC–MS/MS profiling identified 14 flavonoid compounds with diverse biological functions. Among these, Rhamnetin-3-O-β-D-glucopyranoside, Kaempferol-3-O-rutinoside, and Nelumboroside A exhibited the strongest antioxidant and free radical scavenging activities, while Baicalein-7-O-β-D-glucopyranoside and Kaempferol-3-O-rutinoside demonstrated relatively higher anti-inflammatory potential. Molecular docking and dynamics simulations showed Luteolin as the most promising multifunctional compound, exhibiting stable binding affinities toward LOX5 (−7.5 kcal/mol) and COX2 (−9.6 kcal/mol) targets, with comparable binding residues to the control ligand, Celecoxib. Root mean square deviation and root mean square fluctuation analyses confirmed the stability of the COX2–Luteolin complex, indicating reliable protein–ligand interaction. Furthermore, ADME predictions supported Luteolin’s favorable pharmacokinetic profile, including optimal lipophilicity (logP 0.19) and acceptable oral absorption. Collectively, these results demonstrate the successful optimization of OPLE enrichment and provide molecular-level evidence of its bioactivity. Luteolin emerged as a potential lead compound with balanced antioxidant and anti-inflammatory activities. This study highlights the high biopharmaceutical value of oil palm leaves as a sustainable source of natural therapeutics, promoting their use beyond agricultural waste.
Co-Authors Aksa, Annisa Aulia Djoko Santoso Fitriyah, Fauziatul Permatasari, Galuh PERMATASARI, Galuh Wening Putra, Ludwinardo Widodo Widodo