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All Journal INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik
Kurniawati, Fivy
Department Of Pharmacology And Clinical Pharmacy, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

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Evaluation of Pain Scale Decrease and Adverse Effects of Ketorolac Injections: An Observational Study in Patients with Postoperative Pain Mawardi Ihsan; Fivy Kurniawati; Husna Khoirunnisa; Belladonna Chairini
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (947.387 KB) | DOI: 10.14499/indonesianjpharm30iss2pp133-140

Abstract

The use of ketorolac injections in Indonesia is restricted with the provision of 2-3 ampoules per day with a maximum of two days even though the literature states that ketorolac could be used for no more than five days. This study aimed to determine the decrease in pain scale as well as gastrointestinal and renal adverse effects of ketorolac injections in two days of use. This study was an observational study with one-group pre-test post-test design conducted prospectively. The group was a group of patients with postoperative pain who received ketorolac injections and were treated during January till April 2018 in an academic hospital in Yogyakarta. The results showed that ketorolac injections did not provide a statistically significant decrease in pain scale in two days of use compared to before surgery (median [range] = 2.0[0.0-9.33] vs 1.33[0.0-8.33]; p=0.32). Ketorolac injections decreased the kidney function of subjects in two days of use compared to before surgery based on creatinine values (0.76mg/dL vs 0.80mg/dL; p=0.024) and GFR (96.13mL/min/m2 vs 87.52mL/min/m2; p=0.023), and as many as 31 subjects (43.06%) experienced complaints that were suspected to be the gastrointestinal adverse effects of ketorolac injections with the three most complaints were bloating (18.06%), nausea (16.67%), and heartburn (15.28%). Those three results support the use of ketorolac injections following what has been regulated in the Indonesian National Formulary.
Explorative Study on Hipertension Treatment among Pregnant Women Anis Ristyaningsih; Fivy Kurniawati; Nanang Munif Yasin
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 8, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.4 KB) | DOI: 10.22146/jmpf.40929

Abstract

Maternal mortality in Indonesia is relatively high, hypertension becomes one of the causes. Hypertension and complication give particular contribution on morbidity and mortality on neonatal and maternal. On the other hand, antihypertensive drug use in  pregnancy has both benefit and risk. Therefore, appropriate hypertension management needs to be assesed in order to minimize the risk in mother and baby. The aim of the study is to determine the utilization pattern of antihypertensive drugs that will be assesed for suitability with the standard of medical service and American College of Obstetrics and Gynecologists (ACOG) guideline, as well as to determine clinical outcome of the therapy, which includes achieving target blood pressure, proteinuria, and edema. This study was a cross-sectional study with retrospective data collected from hospitalized patients’ medical record in RS PKU Muhammadiyah Yogyakarta from 2012 – 2015. The data of patients’ medical records according to inclusion and exclusion criteria was obtained using consecutive sampling method. Data obtained was analyzed descriptively and reviewed with the suitability of standard of medical service and ACOG guideline. Research shows that most widely used antihypertensive drugs are nifedipine by 51,8%, methyldopa by 2,6%, and amlodipine by 2,6%. Based on the evaluation of sensibility of treatment, 75,3% stated right indication, 100% right patient, and right medication and dosage. Clinical outcome includes blood pressure that had achieved the target as many as 77 patient, with negative value of proteinuria and edema. Blood pressure when patients were dismissed from the hospital was on average of 128,9±15,9/85±10,9 mmHg. In general, the utilization pattern of hypertension drugs in pregnant women has been well and according to the standards used.
Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital Ardhanarishwari Umi Salamah; Fita Rahmawati; Fivy Kurniawati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 9, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.40930

Abstract

Drugs’ administration among hospitalized patients in ICU commonly is given intravenously. Mixing the intravenous drugs may result in incompatibility problem that might affect the drugs’ stability and bioavailability. The aim of the study was to investigate the potential incompatibility problem of  intravenous mixing drugs’ administration among ICU patients at PKU Muhammadiyah Yogyakarta Hospital. This study was a cross-sectional study in which design and data was obtained from ICU patients’ medical record retrospectively with purposive sampling in order to observe the pattern of intravenous drug’s combination. The potential incompatibility problem was analyzed using Handbook on Injectable Drugs. There were 79 out of 119 medical records which fulfilled sample inclusion criteria taken in this study. Parenteral dosage form was commonly used rather than non parenteral (62.06%) among ICUs’ patients. The potential incompatibility pattern consisted of incompatibility of intravenous drugs, electrolyte solutions/parenteral nutritions in mixture form, and the electrolyte solutions/parenteral nutritions, which are administrated simultaneously. Potential incompatibility of intravenous dosage was found in 50 events out of 79 patients (0.63 events per patients), which consisted of 8 events (8.51%) in using of drugs administrated simultaneously, 10 events (19.23%) in using of electrolyte solutions/parenteral nutritions in mixture form, and 32 events (11.72%) in using of electrolyte solutions/parenteral nutritions administrated simultaneously. Common potential incompatibilities types were precipitation of drugs and drug’s adsorption to packaging materials.
Medication Literacy for Pharmacists: A Review Niken Nur Widyakusuma; Chairun Wiedyaningsih; Fivy Kurniawati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 9, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.524 KB) | DOI: 10.22146/jmpf.41550

Abstract

The term health literacy has been emerging since the last decades. Poor health literacy had been realized as a main factor for poor health outcomes, higher medical costs, greater risk of death, and poor health status. With the health care system becoming increasingly complicated and the abundance of unclear health information, the ability to understand health information is important for the patients. Health literacy in the context of medicine was also being studied using different terms. It is rather difficult to compile when interventions to improve health literacy is in need of review. At the moment, the term “medication literacy” has been defined internationally by experts. With this definition, medication literacy studies will have the same concept and will be easier in benchmarking between studies. It is very important for pharmacists to recognize and assist patients with limited medication literacy. Although there are several barriers to do improvement in medication literacy, pharmacists can help both individually and through the system. Some of the interventions that can be carried out by pharmacists are assistance with drug information using literacy-sensitive techniques such as repetition, open questions, devices, demonstration on how to use drugs, and using printed materials to ensure patients understand their condition and treatment plans. Unfortunately, practicing pharmacists are lack of knowledge and even interest in medication literacy.
Kajian Adverse Drug Reactions Terkait Interaksi Obat di Bangsal Rawat Inap Rumah Sakit Akademik UGM Fivy Kurniawati; Nanang Munif Yasin; Amila Dina; Sanses Atana; Sarah Nabila Hakim
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.60228

Abstract

Adverse Drug Reactions (ADRs) is one of the causes of patient’s prolonged length of stay in the hospital and drug interactions can be included as one of the causes of the cause of ADRs. ADR related to drug interactions is a clinical problem that requires proper prevention. This study aimed to identify potential drug interactions also identify adverse drug reactions (ADRs) related to drug interactions in hospitalized patients at Universitas Gadjah Mada Teaching Hospital. This cross-sectional study used retrospective data collection through patient’s medical records from January to June 2018. Patients included in this study were all patients who received therapy more than two kind of drugs simultaneously treated in hospital wards of Universitas Gadjah Mada Teaching Hospital, Yogyakarta, Indonesia. The data collected were then analyzed descriptively. Drug interactions were analyzed using Drug Interaction Facts 2012 and Stockley. ADRs were analyzed by monitoring documented effects of patients with potential drug interaction. There were 115 of 362 patients (31.8%) with potential drug interactions. The total numbers of potential interactions that occur were 182 interactions. The most potential type of interaction was the interaction with moderate severity, with 115 interactions (63.2%). The majority of drug interactions occur through unknown mechanisms (54.4%). Actual ADR occurs in 3.3% patients who were 2 pediatric patients and 4 geriatric patients. This study can be a reference for drug interactions and ADRs as well as guide for pharmacist and healthcare in providing the right medication.
Penggunaan Antibiotik Profilaksis dalam Setting Klinik Bedah: Suatu Studi Cross-Sectional Kurniawati, Fivy; Yasin, Nanang Munif; Rini, Desi Setya; Hidayatika, Annisa
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i4.99639

Abstract

Bedah merupakan salah satu komponen pelayanan kesehatan yang penting karena selain dapat menghilangkan penderitaan pasien bedah juga melibatkan biaya yang mahal. Penggunaan antibiotik profilaksis yang tepat pada pembedahan merupakan hal yang penting dalam keberhasilan penyembuhan luka pasien untuk kembali normal, selain itu juga terkait pencegahan terhadap percepatan resistensi antibiotik. Tujuan dari penelitian ini adalah untuk mengetahui gambaran dan mengindentifikasi kesesuaian penggunaan antibiotik profilaksis pasien bedah digesti dan bedah ortopedi dewasa di Rumah Sakit Akademik Universitas Gadjah Mada. Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional. Pengambilan data dilakukan secara retrospektif melalui rekam medis pasien. Pasien yang masuk dalam penelitian ini adalah pasien usia 18- 64 tahun mendapat antibiotik profilaksis dengan data rekam medis lengkap. Data dianalisis dan ditampilkan secara deskriptif. Hasil penelitian menunjukkan bahwa dari 146 pasien yang terlibat dalam penelitian ini terdapat 71,9 % pasien sesuai indikasi, 45,2 % pasien sesuai jenis antibiotik dengan penggunaan terbanyak adalah seftriakson, 22,6 % pasien sesuai durasi, dan 15,1 % pasien sesuai dosis dan waktu administrasi. Penelitian menunjukkan bahwa sebagian besar pasien menerima antibiotik profilaksis sesuai indikasi tetapi tidak pada dosis dan waktu pemberian.
Studi Perbandingan Penggunaan Antiplatelet Sebelum Dan Sesudah Adanya “Clinical Pathway Stroke Iskemik” Ni’mah, Farihatun; Kurniawati, Fivy; Yasin, Nanang Munif
Majalah Farmaseutik Vol 21, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i1.104705

Abstract

Stroke merupakan penyebab kematian dan disabilitas jangka panjang. Sebagian besar kejadian stroke adalah stroke iskemik. Pemberian antiplatelet secara tepat perlu dilakukan untuk mencegah kejadian stroke berulang dan kejadian kardiovaskuler lainnya. Tujuan penelitian ini adalah untuk mengetahui gambaran penggunaan obat antiplatelet, ketepatan penggunaan antiplatelet, dan gambaran status keluar pasien pada pasien stroke iskemik sebelum dan sesudah berlakunya “Clinical Pathway (CP) Stroke Iskemik” di RS PKU Muhammadiyah Yogyakarta. Penelitian ini merupakan penelitian cross sectional yang pengambilan datanya dilakukan secara retrospektif dengan metode purposive sampling. Subyek penelitian terdiri dari 32 pasien sebelum berlakunya CP dan 32 pasien sesudah berlakunya CP. Evaluasi ketepatan penggunaan antiplatelet dilakukan menggunakan standar pelayanan medik dan Formularium RS PKU Muhammadiyah Yogyakarta, American Heart Association/American Stroke Association guideline untuk pasien sebelum berlakunya CP dan “Clinical Pathway Stroke Iskemik” RS PKU Muhammadiyah Yogyakarta untuk pasien sesudah berlakunya CP. Data yang diperoleh selanjutnya dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa dari 64 pasien (32 pasien sebelum CP dan 32 pasien sesudah CP), 20 pasien periode sebelum berlakunya CP mendapatkan antiplatelet aspirin, klopidogrel, cilostazol, dan 25 pasien periode setelah berlakunya CP mendapat antiplatelet aspirin, klopidogrel. Ketepatan penggunaan antiplatelet pada pasien sebagian besar adalah tepat, dengan kriteria tepat indikasi (62,5% sebelum berlakunya CP; 78,1% sesudah berlakunya CP), tepat obat (100% sebelum berlakunya CP; 56% sesudah berlakunya CP), tepat dosis (75% sebelum berlakunya CP; 80% sesudah berlakunya CP), dan tepat pasien (100% sebelum berlakunya CP; 100% sesudah berlakunya CP). Status keluar pasien sebagian besar dengan status membaik (sebelum berlakunya CP sebanyak 19 pasien; sesudah berlakunya CP sebanyak 23 pasien). Penelitian ini menunjukkan bahwa penerapan CP dapat meningkatkan ketepatan dalam pemilihan antiplatelet yang tepat.
Evaluation of Adverse Drug Reaction Reporting on the Badan POM Website in Yogyakarta Special Region Ernawati, Hafifah; Ikawati, Zullies; Puspitasari, Ika; Abdoellah, Siti Asfijah; Kurniawati, Fivy
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.105134

Abstract

Background: Adverse Drug Reaction (ADR) is defined as a harmful and unintended response to a drug, as a part of the pharmacovigilance system to identify drug safety-related issues. As a regulatory, the Indonesian Food and Drug Authority (BPOM) has facilitated an online reporting platform for healthcare professionals via the website www.e-meso.pom.go.id.Objectives: The objective of this study is to characterize Adverse Drug Reaction (ADR) reporting within the Special Region of Yogyakarta, serving as an early detection mechanism for potential drug safety hazards.Methods: This observational cross-sectional survey study utilized ADR reporting data obtained from the MESO website of the Indonesian Food and Drug Authority in the Special Region of Yogyakarta (DIY). The collected data were subjected to descriptive analysis. A total of 169 reports were analyzed, encompassing 255 suspected drugs and 255 ADR events.Results: The report identifies three predominant groups of patient disease characteristics: diseases of the circulatory system (15.38%), certain infectious and parasitic diseases (11.24%), and diseases of the respiratory system (9.47%). Regarding the type of ADR based on its Sub Organ Class (SOC), Skin and subcutaneous tissue disorders is most frequently involved (21.57%). The antibiotic group is the most commonly suspected type of drug (34.90%), with Levofloxacin and Ceftriaxone being the most implicated in causing ADR (11.24%). Oral administration is the most common route associated with ADR, followed by intravenous administration.Conclusion: In 2023, the monitoring of ADR in the Special Region of Yogyakarta revealed that antibiotics were the most frequently suspected drug class in relation to ADR. The dermatological organ system was also identified as the predominant organ affected by these reactions.
Co-Authors Abdoellah, Siti Asfijah Amila Dina Anis Ristyaningsih Ardhanarishwari Umi Salamah Atana, Sanses Belladonna Chairini Chairun Wiedyaningsih Dina, Amila Ernawati, Hafifah Fita Rahmawati Hakim, Sarah Nabila Hidayatika, Annisa Husna Khoirunnisa Ika Puspitasari Mawardi Ihsan Nanang Munif Yasin Nanang Munif Yasin Nanang Munif Yasin Niken Nur Widyakusuma Ni’mah, Farihatun Rahmawati, Fita Rini, Desi Setya Salamah, Ardhanarishwari Umi Sanses Atana Sarah Nabila Hakim