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All Journal The Indonesian Biomedical Journal Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Wilianto, Yufita Ratnasari
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Side Effects of Antipsychotics on Schizophrenia Patient : A Literature Review Wilianto, Yufita Ratnasari
Pharmaceutical Journal of Indonesia Vol 4, No 2 (2019)
Publisher : Brawijaya University

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Abstract

Schizophrenia is a chronic mental disorder that is charactherized by distracted mind, behavioral changes, including delusions and hallucinations. The  incidence of schizophrenia is 1.25% of the 2.47% of the population with psychotic disorders. Pharmacological therapy given to schizophrenia patient is an antipsychotics that works on the brain neurotransmitters including dopamine, serotonin, and glutamate. Atypical antipsychotics agents are first-line therapy for schizophrenia, whereas typical antipsychotics are used as second line when there is no improvement. However antipsychotics agents have frequent risk of side effects such as weight gain and extrapyramidal symptoms. Other reported side effects include increased prolactin levels (sexual dysfunction and menstrual irregularity), cardiovascular system (hypotension and prolonged QT interval), and lipid changes (elevated triglyceride and cholesterol). Consequences of these side effect can lead to poor adherence of patient, disease progressiveness and increase of physical morbidity and mortality. The purpose of this article is to provide a concise review of schizophrenia and discusses the side effects of atypical and typically  antipsychotics based in literature review.
Co-Authors Bhendy, Maria Theresia Primadewy Caroline Caroline Chrisantia, Oryza Esar, Senny Yesery Ghasani, Sabrina Maria Herjunianto Herjunianto Irene Lingkan Parengkuan Jafet, Nico Jaya, Ferdinand Wiliam Kusuma, I Made Andika Bara Limantoro, Michael Christian Martha Ervina Novita, Bernadette Dian Palpialy, Sindi Siska Sianty Dewi Soehadi, Shellin Theodora, Imelda Tjahjono, Yudy Wedharga, I Gede Putu Adhi Wijaya, Hendy