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All Journal Jurnal Farmasi Indonesia Jurnal Abdimas Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Esar, Senny Yesery
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Health Professions Medicine & Pharmacology Nursing Public Health

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Uji Aktivitas Analgesik Tablet Asam 4-(Klorometil)Salisilat pada Mencit Putih dengan Metode Writhing Test dan Hotplate Tiffany, Angela; Ribka Abiati, Meidelin; Foe, Kuncoro; Tjahjono, Yudy; Caroline; Esar, Senny Yesery; Hadinugroho, Wuryanto
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (507.738 KB) | DOI: 10.35617/jfionline.v14i1.78

Abstract

Acetylsalicylic acid is an analgesic drug that still popularly used. However, acetylsalicylic acid may result undesirable side effect of gastrointestinal as it can cause gastric ulcer to bleeding. Previous research has succeeded synthesizing new compound derived from salicylic acid, namely 4-(chloromethyl)salicylic acid which has the potential to reduce its side effects with a better pharmacological effects than acetylsalicylic acid. In its development, the formulation of the compound in tablet dosage form has been carried out. However, until now there has not been a pharmacological test to determine whether it still provides a greater effect than acetylsalicylic acid after being formulated. This study is to test the analgesic activity of 4-(chloromethyl)salicylic acid tablets in albino mice using writhing test and hotplate methods. Analgesic activity test using the hotplate method was carried out on albino mice which given the suspension of the tablet sample and the observations were made in a periodic of time. Analgesic activity test using writhing test method was carried out in 0.6% acetic acid-induced albino mice, where the suspension of the tablet was administered 30 minutes before administration of acetic acid. Analgesic activity was assessed by counting the number of writhings, and the results were statistically compared with one-way ANOVA. Tests were also performed on acetylsalicylic acid as a positive control and suspension as a negative control group.  There were significant differences (P<0.05) of the analgesic activity observed among groups. Both methods show that 4-(chloromethyl)salicylic acid tablets provide stronger analgesic activity than acetylsalicylic acid.
Deteksi populasi Cd3+Cd4+Cd25+Foxp3+ T-regulator pada Limpa Mencit Galur Balb/c dan Swiss-webster yang Mudah dan Cepat dengan Metode Flow Cytometry Tjahjono, Yudy; Wijaya, Hendy; Esar, Senny Yesery; Caroline, Caroline; Jafet, Nico; Kusuma, I Made Andika Bara; Chrisantia, Oryza; Bhendy, Maria Theresia Primadewy; Palpialy, Sindi Siska; Soehadi, Shellin; Wilianto, Yufita Ratnasari
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 2 (2022): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i2.4079

Abstract

Sel T-regulator (Treg) memainkan peran kunci dalam mengendalikan autoimunitas, respon alergi, peradangan, dan respons terhadap infeksi. Sel T Cd4+ yang secara konstitutif mengekspresikan Cd25 dan protein forkhead 3 (Foxp3; yaitu, Cd3+Cd4+Cd25+Foxp3+) atau disebut juga sebagai Treg fungsional, telah terbukti memainkan peran utama dalam pemeliharaan toleransi dan homeostasis imun, sehingga deteksi Treg fungsional sangat penting dilakukan sebagai salah satu parameter imunomodulasi. Penelitian ini bertujuan untuk mendeteksi populasi sel Treg (Cd3+Cd4+Cd25+Foxp3+) pada organ limpa mencit galur Balb/c dan Swiss-webster dengan menggunakan metode yang mudah, cepat, serta terjangkau. Metode deteksi sel Treg dilakukan dengan cara isolasi organ limpa mencit Balb/c dan Swiss-webster kemudian dilakukan preparasi dan deteksi sel menggunakan instrumen flow cytometry. Hasil populasi sel Treg yang didapatkan berturut-turut pada mencit Balb/c dan Swiss-webster adalah 2,02 ± 0,36% dan 3,14 ± 1,64% dari total populasi yang dideteksi dengan hanya membutuhkan waktu 145 menit sejak pembedahan. Berdasarkan hasil tersebut dapat disimpulkan bahwa pengamatan populasi sel Treg pada splenosit mencit galur Balb/c dan Swiss-webster dengan flow cytometry dapat dilakukan dengan mudah dan praktis dengan pewarnaan kombinasi antibodi yang tertera pada manuskrip ini. Selain itu, metode pewarnaan yang tertera dapat digunakan sebagai salah satu acuan untuk mendeteksi imunomodulator pada berbagai model hewan coba yang menggunakan mencit galur Balb/c dan Swiss-webster, khususnya yang berhubungan dengan populasi sel Treg.
Pelatihan Pembuatan Water Kefir sebagai Minuman Probiotik Caroline, Caroline; Ervina, Martha; Hadinugroho, Wuryanto; Esar, Senny Yesery; Wijaya, Hendy; Tjahjono, Yudi; Handayani, Yuliastuti Ika; Sutedja, Anita Maya
Jurnal Abdimas Kesehatan (JAK) Vol. 6 No. 2 (2024): Juni
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jak.v6i2.620

Abstract

Christ the King of Surabaya Parish through the Socio-Economic Development Section (PSE) in collaboration with Widya Mandala Catholic University Surabaya, was committed to assisting the Indonesian government's program in terms of improving the post-pandemic family economy through training in making health drinks from herbal ingredients, namely water kefir, which has been used as a probiotic drink. The training participants were underprivileged families in the Parish of Christ the King Surabaya. The training was carried out for 1 day with presentation of material by the team, training implementation and training evaluation by filling out pre-tests, post-tests and questionnaires as well as 30 days of assistance for participants who were interested in developing products to improve their economy. The results of the training show high enthusiasm from the participants, an increase in the knowledge of the participants which was marked by an increase in the value of the posttest compared to the pretest and the desire of the participants to produce and market products to improve the family economy
Co-Authors Anita Maya Sutedja Bhendy, Maria Theresia Primadewy Caroline Caroline Caroline Chrisantia, Oryza Foe, Kuncoro Handayani, Yuliastuti Ika Jafet, Nico Kusuma, I Made Andika Bara Martha Ervina Palpialy, Sindi Siska Ribka Abiati, Meidelin Soehadi, Shellin Tiffany, Angela Tjahjono, Yudi Tjahjono, Yudy Wijaya, Hendy Wilianto, Yufita Ratnasari Wuryanto Hadinugroho