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All Journal SCIENTIA JOURNAL Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) The Journal of Society Medicine (JSOCMED)
Sinaga, Ade
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Efektivitas Ekstrak Daun Mangkokan Terhadap Penyembuhan Luka Bakar Pada Tikus Revina, Monica; Yuliani, Riski; Putri, Monica; Hulu, Welpin; Sinaga, Ade; Budi, Setia; Nasution, Sri Lestari Ramadhani
SCIENTIA JOURNAL Vol 7 No 2 (2018): SCIENTIA JOURNAL
Publisher : Universitasdiwangsa Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/scj.v7i2.524

Abstract

Luka  bakar adalah bentuk kerusakan dan/atau kehilangan jaringan akibat kontak dengan sumber panas dan suhu tinggi (seperti api, air panas, dll) atau suhu yang sangat rendah. Kini sedang dikembangkan terapi luka bakar melalui pemberian topikal ekstrak herbal. Daun Mangkokan (Nothopanax scutellarium) adalah salah satu herbal yang dapat digunakan untuk terapi luka bakar.             Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun Mangkokan dalam bentuk sediaan salep terhadap penyembuhan luka bakar pada hewan uji yaitu tikus putih. Penelitian ini dimulai dengan melakukan proses ekstraksi daun Mangkokan (Nothopanax scutellarium), kemudian dilakukan skrining fitokimia untuk mengidentifikasi alkaloid, flavonoid, saponin, dan tanin. Lalu dibuat salep ekstrak daun Mangkokan (Nothopanax scutellarium) dengan konsentrasi 50% dan 75%. Hewan uji yaitu tikus putih, sebelumnya sudah dipersiapkan selama 1 minggu sehingga hewan uji mampu beradaptasi. Dilakukan pembuatan luka bakar pada bagian punggung kanan tikus. Selanjutnya dilakukan penyembuhan luka bakar, disiapkan 4 kelompok hewan uji yaitu: K1: tidak diberi perlakuan (kontrol negatif); K2: Diberikan sediaan bioplacenton (kontrol positif); K3: diberikan sediaan salep ekstrak daun Mangkokan konsentrasi 50%; K4: diberikan sediaan salep ekstrak daun Mangkokan konsentrasi 75%. Pengolesan dilakukan secara merata 2 kali sehari, pagi dan sore, kemudian ditutup dengan kassa steril. Luka diamati selama 21 hari, setiap 3 hari sekali dengan mengamati secara makroskopik. Berdasarkan hasil pengujian senyawa kimia terbukti bahwa ekstrak daun Mangkokan mengandung senyawa alkaloid, saponin, flavonoid dan tannin. Berdasarkan hasil penelitian pada hari ke-21, pada kelompok KI keropeng sudah terkelupas semua namun daerah yang terkelupas masih terlihat basah, bentuk ukuran mengecil, daerah bekas luka masih terlihat kotor. Pada kelompok K2 dan K3, keropeng sudah terkelupas dan kering, ukuran mengecil, dan pada K4 keropeng sudah tidak terlihat, warna hampir merata dan ukuran sudah jauh lebih mengecil, bekas luka lebih bersih. Hasil penelitian ini menunjukan bahwa salep ekstrak daun Mangkokan mempercepat penyembuhan luka bakar pada tikus putih.
EVALUATION OF EFFECTIVENESS OF MORINGA'S LEAVES AGAINST Escherichia coli USING DISC DIFFUSION METHOD Dhillon, Erin; Rotua, Margaretia Yenni; Khu, Adrian; Sinaga, Ade
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 7 No. 1 (2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (782.577 KB) | DOI: 10.22487/htj.v7i1.146

Abstract

The UPTD Puskesmas annual report book in Medan Tembung District reported that the number of diarrhea sufferers had increased every year. Moringa plants have many benefits, both leaves, flowers, stems, fruit blossoms, and seeds. The moringa leaves contain various phytochemicals, viz. alkaloids, flavonoids, phenols, steroids, triterpenoids, and tannins, which have antimicrobial properties. This study aimed to determine the antimicrobial effect of the ethanol extract of Moringa leaves against Escherichia coli. This study was an experimental study with a posttest only control group design model. The method used to evaluate ethanol extract's anti-bacterial effect from Moringa leaves was the disc diffusion method. Moringa leaf extract was obtained by maceration method with a ratio of Simplicia powder, and ethanol solvent was 1:10. The ethanol extract was then concentrated by rotary evaporator and diluted using DMSO into five different concentrations viz. 70%, 75%, 85%, 90%, and 95%. All data were analyzed by the One Way Anova test and expressed as Mean ± SD. This study showed that all treatment groups in this study had a significant difference in the zone of inhibition; it was shown by the P-value <0.05. Only 70% of concentrations from Serial concentration of extract were significant differences against the positive control. Overall, it can be concluded that the ethanol extract of moringa leaves is effective as an anti-bacteria against Escherichia coli, especially at concentrations > 75%.
Correlation Analysis of Lemon, IDS, and Wilson Scores in Assessing Intubation Difficulty in Patients Undergoing General Anesthesia Sinaga, Ade; Hamdi, Tasrif; Tanjung, Qadri Fauzi
Journal of Society Medicine Vol. 3 No. 8 (2024): August
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i8.159

Abstract

Introduction: The act of intubating with an endotracheal tube is a definitive airway management technique that provides maximal protection against the occurrence of aspiration of stomach contents or fluids. Some studies recommend the use of a head pillow to improve the laryngoscopic view by enhancing the occipito-atlanto-axial angle and enlarging the submandibular space. The aim of this study was to find out comparison of the level of difficulty of intubation in intubation techniques with and without the use of pillows. Methods: The design of this study was a randomized cross-sectional study with two research groups conducted to compare the difficulty levels of intubation using the technique with and without a pillow. Results: Patients without a pillow often required a little assistance during intubation, while the majority of patients using a pillow were easily intubated. However, no significant difference was found between the two groups (p>0.05). Patients intubated without a pillow had an average score of 15.9±1.6, while those intubated with a pillow had an average score of 10.8±1.8, showing a significant difference between the two groups (p<0.05). Using the Cormack-Lehane score, most patients without a pillow were at grade 2, while the majority of patients with a pillow were at grade 1. A significant difference was found between the two groups (p<0.05). Conclusion: Patients intubated without a pillow often required a little assistance, while the majority of patients intubated with a pillow were easily intubated; however, no significant difference was found between the two groups (p>0.05).
Co-Authors Adrian Adrian Dhillon, Erin Hamdi, Tasrif Hulu, Welpin Nasution, Sri Lestari Ramadhani Putri, Monica Qadri Fauzi Tanjung Revina, Monica Rotua, Margaretia Yenni Setia Budi Yuliani, Riski