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All Journal Jurnal Farmasi Sains dan Praktis Pharmacon: Jurnal Farmasi Indonesia Indonesian Journal of Jamu
Syarifah, Arini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULATION AND ACTIVITY TESTS OF NANOEMULSION OF TURMERIC RHIZOME (CURCUMA LONGA L) EXTRACT FOR METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) BACTERIA Syarifah, Arini; Azizah, Wafiqotul; Prasuma, Galar Sigit
Jurnal Farmasi Sains dan Praktis Vol 10 No 3 (September-December 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i3.10800

Abstract

Turmeric rhizome (Curcuma longa L) contains the main active compound curcumin, which has antibacterial activity which inhibits Methicillin-Resistant Staphylococcus aureus (MRSA). Developing a nanoemulsion formula for turmeric rhizome extract can overcome bacterial resistance by protecting the active substance from degradation and blocking the efflux pump in bacteria. This research aims to create a nanoemulsion formulation and determine the activity of turmeric rhizome extract nanoemulsion against MRSA bacteria in vitro. Method: Turmeric rhizomes were extracted using the maceration method using 70% ethanol solvent. The technique of nanoemulsion preparation was by using the spontaneous emulsification method with varying extract concentrations of 1.25% (F1), 2.50% (F2), and 3.75% (F3). Evaluation of the physical characteristics of nanoemulsions includes particle size, polydispersity index, zeta potential, viscosity, and pH. In vitro activity test of turmeric rhizome extract nanoemulsion using the diffusion method against MRSA bacteria. The turmeric rhizome extraction process produces a yield value of 14.3%. The best formula for turmeric rhizome extract nanoemulsion is F1 with a viscosity value of 134.6 ± 21.3 Cps, pH value of 6.34, particle size value of 33.4 ± 12.8 nm, polydispersity index of 0.407 ± 0.01, zeta potential -14.2±2.9 mV. Turmeric extract nanoemulsion can inhibit the growth of Methicillin-Resistant Staphylococcus aureus bacteria with an inhibition zone of 11.00 mm at F3. Conclusion: Curcumin can be formulated in a nanoemulsion system without providing significant changes in organoleptic tests, viscosity, pH, nanoemulsion type tests, particle size, polydispersity index, and zeta potential. Turmeric extract nanoemulsion has an antibacterial effect against MRSA in vitro.
Optimization of Microgel Formula Combination of Snail Mucus and Catechin to Accelerate Wound Closure Azizah, Adinda Fayi; Astuti, Ika Yuni; Syarifah, Arini; Kumalasari, Raudia; Agistya, Lusyahaura; Talitarahma, Anindya Tian
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.7562

Abstract

Incised wound healing is a crucial process that requires effective treatment solutions. A microgel containing snail mucus and catechin seems a promising approach to accelerate healing and improve recovery outcomes. This study aimed to develop a microgel preparation contain snail mucus (Achatina fulica) and catechin. Formulation design is assisted using the Design Expert SLD method. The optimum formula was achieved with a carbopol to TEA ratio of 1.589:0.411, with estimated values of pH (4.506), viscosity (18,873 cPs), spread ability (5.477 cm), and adhesion (2.068 second). These estimated values showed no significant difference from the actual values obtained in the laboratory experiments. To evaluate the quality of the preparation, in vivo testing was performed on white mice, and the data were analysed using one-way ANOVA. The snail mucus and catechin microgels were proven to be effective in treating deep incision wounds.
Crude Drug Standardization, Formula Optimization, and Interaction Effects of a Five-Component Antioxidant Polyherbal Formulation Wardani, Tri Kusuma; Arianingsih, Elfa; Syarifah, Arini; Hamad, Alwani; Hartanti, Dwi
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.353

Abstract

A polyherbal formulation was developed from java tea (Orthosiphon aristatus (Blume) Miq.), turmeric (Curcuma longa L.), seed-under-leaf (Phyllanthus niruri L.), cinnamon (Cinnamomum verum J. Presl), and ginger (Zingiber officinale Roscoe). This study aimed to standardize crude drugs, optimize polyherbal formulations, and evaluate the interaction effect of the crude drug mixture. Standardization followed these methods and compared them with the Indonesian Herbal Pharmacopeia (IHP) standards. The crude drugs were mixed in 26 different ratios, and each formulation was extracted using the decoction method. The antioxidant activities of the extracts were evaluated using 2-diphenyl-2-picryl hydroxyl scavenging (DPPH) radical scavenging activity and ferric-reducing antioxidant power (FRAP) assays. The optimum formula was obtained by antioxidant activity-based prediction using the simplex lattice design (SLD) method. The interaction effects of crude drug mixtures were determined using a statistical comparison method for the predicted and obtained antioxidant activities. Crude java tea, turmeric, cinnamon, and ginger were of good quality. The five-component formulation with optimum antioxidant activity consisted of java tea, turmeric, seed-under-leaf, cinnamon, and ginger crude drugs in a ratio of 20-20-40-10-10 with interaction effects of additive toward DPPH radical scavenging activity (7.05±0.94 µmol TE/g) and antagonistic toward FRAP (19.37±0.94 µmol TE/g). Formula 21 (mixture of java tea and seed-under-leaf crude drugs) showed the highest DPPH scavenging activity (6.39±0.16 µmol TE/g) with synergistic effects, while the synergistic, highest FRAP (23.74±0.03 µmol TE/g) was shown by Formula 13 (mixture of seed-under-leaf and ginger crude drugs). 
Co-Authors Agistya, Lusyahaura Alwani Hamad Arianingsih, Elfa Azizah, Adinda Fayi Azizah, Wafiqotul Dwi Hartanti Ika Yuni Astuti Kumalasari, Raudia Prasuma, Galar Sigit Talitarahma, Anindya Tian Wardani, Tri Kusuma