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FORMULATION AND ACTIVITY TESTS OF NANOEMULSION OF TURMERIC RHIZOME (CURCUMA LONGA L) EXTRACT FOR METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) BACTERIA Syarifah, Arini; Azizah, Wafiqotul; Prasuma, Galar Sigit
Jurnal Farmasi Sains dan Praktis Vol 10 No 3 (September-December 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i3.10800

Abstract

Turmeric rhizome (Curcuma longa L) contains the main active compound curcumin, which has antibacterial activity which inhibits Methicillin-Resistant Staphylococcus aureus (MRSA). Developing a nanoemulsion formula for turmeric rhizome extract can overcome bacterial resistance by protecting the active substance from degradation and blocking the efflux pump in bacteria. This research aims to create a nanoemulsion formulation and determine the activity of turmeric rhizome extract nanoemulsion against MRSA bacteria in vitro. Method: Turmeric rhizomes were extracted using the maceration method using 70% ethanol solvent. The technique of nanoemulsion preparation was by using the spontaneous emulsification method with varying extract concentrations of 1.25% (F1), 2.50% (F2), and 3.75% (F3). Evaluation of the physical characteristics of nanoemulsions includes particle size, polydispersity index, zeta potential, viscosity, and pH. In vitro activity test of turmeric rhizome extract nanoemulsion using the diffusion method against MRSA bacteria. The turmeric rhizome extraction process produces a yield value of 14.3%. The best formula for turmeric rhizome extract nanoemulsion is F1 with a viscosity value of 134.6 ± 21.3 Cps, pH value of 6.34, particle size value of 33.4 ± 12.8 nm, polydispersity index of 0.407 ± 0.01, zeta potential -14.2±2.9 mV. Turmeric extract nanoemulsion can inhibit the growth of Methicillin-Resistant Staphylococcus aureus bacteria with an inhibition zone of 11.00 mm at F3. Conclusion: Curcumin can be formulated in a nanoemulsion system without providing significant changes in organoleptic tests, viscosity, pH, nanoemulsion type tests, particle size, polydispersity index, and zeta potential. Turmeric extract nanoemulsion has an antibacterial effect against MRSA in vitro.
PEMANFAATAN LIMBAH MERANG PADI MENJADI PRODUK SHAMPOO DAN HANDSOAP DI DESA GENTASARI Hasanatun Nida, Shofiyah; Fahrizal, Muchammad Ijran Rijal; Oktafiana, Lutfi; Kamaluddin, Raihan; Bramila, Fidela Ayustia; Ariyanti, Zulfaa Haniifah; Prasuma, Galar Sigit
DedikasiMU : Journal of Community Service Vol 6 No 4 (2024): Desember
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/dedikasimu.v6i4.8349

Abstract

Kegiatan Pengabdian kepada Masyarakat (PkM) bertujuan untuk memperdayakan suatu kelompok masyarakat. Melalui pendekataan Participant Action Research (PAR), pemberdayaan dilakukan pada kelompok tani dan ibu PKK di Desa Gentasari dengan tujuan untuk mengatasi permsalahan pemanfaatan limbah merang padi. Solusi atas permsalahan tersebut dilakukan dengan memberikan sosialisasi dan pelatihan pembuatan produk shampoo dan handsoap berbahan baku merang padi. Berdasarkan evaluasi pre dan post test dari total 15 peserta yang mengikuti kegiatan ini seluruh peserta dinilai berhasil mencapai tujuan dan berhasil menghasilkan produk shampoo dan handsoap yang dapat digunakan untuk kebutuhan sehari-hari. Kegiatan PkM ini diharapkan kedepan dapat membuka peluang untuk komersiliasi produk merang padi sehingga dapat meningkatkan pendapatan masyarakat desa Gentasari.
Promoting Antimicrobial Stewardship in Small Ruminants by Assessing Farmer’s Behavior and Establishing Footbath Strategy at a Community Farm in Purbalingga, Central Java Nurzijah, Ika; Prasuma, Galar Sigit; Darmansah, Muhammad Aris; Berliana, Widya Pratiwi; Akbar, Mohammad Rekhan
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 11, No 3 (2025): September
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.106218

Abstract

Infectious diseases such as lameness remain a persistent health problem for small ruminants in community farming systems. Although antimicrobials are frequently used as a treatment strategy, this practice contributes to increased medication use and raises concerns over antimicrobial resistance. This study assessed behavioral practices surrounding antimicrobial use among farmers at Ngudi Dadi, a community farm in Central Java, Indonesia, and implemented a multifaceted intervention combining farmer training and the construction of a biosecurity-focused footbath.Behavioral data were collected through structured survey with 21 farmers, covering five domains: antimicrobial administration, disposal of veterinary medicines, frequency of antimicrobial use, medication storage, and treatment of sick animals. Behavioral scores varied across categories, with consistently higher scores for treatment practices, but notable gaps in antimicrobial administration and disposal behaviors. Importantly, no significant correlation was observed between years of farming experience and behavioral practice scores (Spearman’s ρ = 0.0488, p = 0.8335), suggesting that practice gaps are widespread regardless of farming experience.Post-survey, a training session was conducted, followed by the construction of a footbath using lemongrass essential oil as a natural disinfectant. The footbath is now routinely used for incoming livestock at Ngudi Dadi Farm, serving as a biosecurity measure that supports reduced reliance on antimicrobials.This study represents the first initiative in Indonesia to integrate behavioral assessment, farmer education, and footbath implementation into a comprehensive antimicrobial stewardship strategy. Expansion of this model to other community farming settings, along with the development of standardized operating procedures, may enhance its scalability and long-term impact.
Implementation of Providing Green Bean Pudding and Nutrition Education Activities to Support Stunting in Karangkemiri Village: Implementasi Pemberian Puding Kacang Hijau dan Kegiatan Penyuluhan Gizi sebagai Penunjang Stunting di Desa Karangkemiri Supriadi, Rizki Abdilah; Fitriyani, Putri Dwi; Anfi, Try; Widiatmini, Indi Ragil; Budiman, Dodo; Nurami, Amara Nabiila Sekar; Prasuma, Galar Sigit
Prosiding University Research Colloquium Proceeding of The 18th University Research Colloquium 2023: Bidang Pengabdian Masyarakat
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Stunting merupakan suatu kondisi gangguan tumbuh kembang pada bayi (0 hingga 11 bulan) dan anak kecil (12 hingga 59 bulan) yang mengalami kekurangan gizi kronis, terutama pada 1.000 hari pertama kehidupan. Banyak faktor yang dapat menyebabkan stunting, antara lain faktor dari dalam diri anak seperti usia, jenis kelamin,berat badan lahir, serta faktor eksternal terutama yang berkaitan dengan anak seperti parameter sosial ekonomi dan kebiasaan mengasuh anak telah berkontribusi terhadap prevalensi stunting, misalnya melalui pemberian ASI ekslusif yang kurang optimal dan pemberian makanan yang buruk, suplemen yang terbatas jumlah, kualitas, dan jenisnya. Tujuan kegiatan ini adalah memberikan pemahaman dan pengetahuan kepada ibu tentang gizi balita, pencegahan stunting, dan pemberian makanan tambahan yaitu pudding kacang hijau dengan harapan dapat meningkatkan pengetahuan para ibu tentang gizi balita dan pencegahan stunting. Hasil setelah kegiatan ini dilakukan, tingkat pengetahuan ibu mengenai gizi dan pencegahan stunting meningkat. Hal ini menunjukkan bahwa program kegiatan ini berhasil.
Analisis Efektifitas Biaya dalam Terapi Jamu Saintifik dan Konvensional untuk Terapi Dispepsia Nurhaliza, Inta; Prasuma, Galar Sigit; Sugiantoro, Ergia Andang; Lianawati, Lianawati; Sutheeraprasert, Praewthip; Setiawan, Didik
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1470

Abstract

Dyspepsia is a common digestive disorder among global health problems. This study aimed to examine the cost-effectiveness of scientific herbs in the treatment of dyspepsia. This study has used a societal perspective, but the indirect costs are considered equal because the patient is undergoing outpatient care. The analysis was used to determine the cost-effectiveness using the Incremental Cost-Effectiveness Ratio (ICER) method. The results were reported in rupiah currency, which includes categories of direct medical costs and direct non-medical costs. Sensitivity analysis reported changes in results, taking into account various possible influencing variables. A total of 62 patients who were respondents in this study were included in scientific herbal therapy (48.38%) and conventional dyspepsia therapy (51.62%). The cost of scientific herbal therapy was higher than conventional dyspepsia therapy (45.558±4.351 vs. 39.202±4.500). However, this difference was not statistically significant on the effectiveness of therapy (96.67% vs. 90.62%; p-value 0.600), the utility index of scientific herbal medicine was greater than conventional dyspepsia therapy (0.85±0.11 vs. 0.74±0.14). The ICER value for 1 additional unit of effectiveness was IDR 105,933; while for the addition of 1 unit of quality of life was IDR 57,781. The effectiveness of scientific herbal medicine therapy for dyspepsia was greater than the effectiveness of conventional dyspepsia therapy, where the cost was higher but the effectiveness was better.