Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Experimental and Clinical Pharmacy (JECP)
Sapra, Amriani
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Diffusion Study of Cream Formula of Lyophilized Ethanol Extract of Moringa oleifera L. Leaves : Studi Difusi Formula Krim Ekstrak Etanol Terliofilisasi Daun Kelor (Moringa oleifera L.) Sapra, Amriani; Mus, Suwahyuni; Dwirandy, Dwirandy; Malluka, Rifka; Khairi, Nur
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15275

Abstract

Background: Moringa oleifera L. leaves have analgesic activity due to their flavonoids content. These polar antioxidants compounds usually have difficulty to diffuse through the skin. Objectives: The purpose of this study was to evaluate the diffusion parameters of cream contains the lyophilized of M. oleifera leaves ethanol extract. Material and Methods: The lyophilized of M.oleifera leaves ethanol extract (5%) formulated as an o/w cream with 2% of cetyl alcohol as a stiffening agent. The physical characteristics of the cream were determined for organoleptic, homogeneity, pH, viscosity, spreadability, and type of emulsion parameters. The diffusion parameters were determined with Franz cell diffusion using the skin's snake as a membrane with 0; 10; 30; 60 and 90 minutes sampling time. Results: Physical characteristics of the cream showed that o/w as the cream type with pH, viscosity, and spreadability value were 4.72±0.03; 14.000±225 cps; and 5.7±0.20 cm, respectively. The diffusion parameter showed total flavonoids penetrate through the membrane was 360.134±0.20 µg/cm2 with flux 239,875 µg/cm2hr. Conclusions: This study showed a cream formulation that fulfills the required physical characteristics standard and can deliver active compounds to penetrate through the membrane.
Optimization of HPMC Concentration in Psidium guajava Leaf Extract Floating Tablets Achmad, Nurafni Annisa; Nasir, Ardiansyah Jumaedi; Sapra, Amriani; Khairi, Nur; Ali, Nurul Ulfah
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1639

Abstract

Psidium guajava L. leaves have been empirically used in traditional medicine due to their flavonoid content, which exhibits antibacterial and anti-ulcer activities. A floating drug delivery system is intended to prolong gastric residence time and thereby enhance therapeutic effectiveness in the treatment of gastric ulcers. This study aimed to investigate the effect of varying concentrations of hydroxypropyl methylcellulose (HPMC) on the physical characteristics of floating tablets containing Psidium guajava leaf extract. The leaf extract, at a dose of 350 mg, was formulated into floating tablets using three HPMC concentrations: 10% (F1), 20% (F2), and 30% (F3). The tablets were evaluated for weight uniformity, hardness, friability, disintegration time, and floating properties. The results showed that all formulations complied with pharmacopeial requirements for weight uniformity, hardness (10-20 kg), friability (<1%), and disintegration time (<60 min). However, formulation F1 exhibited a longer floating lag time of 7200 s and failed to meet the floating ability criterion. Increasing HPMC concentration significantly affected tablet hardness, friability, and floating properties (p < 0.05). Formulation F2 demonstrated the most favorable characteristics, with hardness of 10.61 kg, friability of 0.69%, floating lag time of 60 s, and floating duration >12 h. In conclusion, HPMC concentration significantly influenced the physical and floating properties of Psidium guajava leaf extract floating tablets, with a 20% HPMC concentration providing the most optimal formulation characteristics.
Co-Authors Achmad, Nurafni Annisa Ali, Nurul Ulfah Dwirandy, Dwirandy Khairi, Nur Malluka, Rifka Mus, Suwahyuni Nasir, Ardiansyah Jumaedi