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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Mandala Pharmacon Indonesia Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Pengabdian Kefarmasian Journal of Noncommunicable Diseases (JOND) Jurnal Medika: Medika
Mus, Suwahyuni
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Uji Sitotoksik Ekstrak Daun Murbei (Morul Alba L) Terhadap Sel Kanker Mcf-7 Dan Selektifitasnya lukman, Lukman; Marwati, Marwati; Mus, Suwahyuni; Syahruni, Reny
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 4, No 2 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v4i2.37665

Abstract

Mulberry, Morus alba L., is traditionally used to treat various diseases such as bacterial, fungal, and protozoal. In addition, the society in South Sulawesi uses mulberry leaves as an anti-cancer. The present study aimed to investigate the cytotoxic effect of mulberry leaf extract on breast cancer cells MCF-7 and their selectivity against Vero normal cells. The dried mulberry leaves were extracted by maceration using 96% ethanol. The cytotoxic activity was determined using MTT method, while the selectivity index (SI) was calculated by comparing IC50 of MCF-7 cells against Vero cells. The results showed that the ethanol extract of mulberry leaves was toxic to MCF-7 cells with an IC50 of 75.32±2.78 µg/mL and also toxic to Vero cells (71.73±4.39 µg/mL). However, ethanol extract of mulberry leaves was not selective on MCF-7 cells with an SI value of 0.95. Our study indicates that mulberry could be considered an effective agent in the prevention of cancer, but further studies are necessary needed for safety assessment.
Efek Pemberian Ekstrak Etanol Daun Sembukan (Paederia foetida L.) Terhadap Penurunan Kadar Asam Urat Tikus Putih (Rattus norvegicus) Jantan mus, suwahyuni; Indrisari, Maulita; Maryam, Fadhillah; Surida, Surida
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Jurnal Fitofarmaka Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.801

Abstract

Sembukan leaf is a medicinal plant that is widely used by the community, one of which is as an anti-inflammatory. This study aims to determine the effect of giving sembukan leaves (Paederia foetida L.) to decrease uric acid levels in male white rats (Rattus norvegicus). The study was carried out by testing 5 groups of white rats, namely positive control (Allopurinol 100 mg), negative control (Na.CMC suspension 0.5%), the dose of ethanol extract of sembukan leaves 10 mg/KgBB, 20 mg/KgBB, and 40 mg/KgBB. Each treatment group was measured initial uric acid levels (before induction), after induction of chicken liver juice and after giving treatment or test samples using test strips. The results showed that uric acid levels in all groups decreased with the percentage decrease in uric acid levels at a dose of 10 mg/Kg BB, 20 mg/Kg BB and 40 mg/Kg BB, respectively by 13.2%, 24.5% and 54.3%. The results of the One Way Anova statistical test showed a significant difference with P value = 0.010 (α <0.05). The concentration of the extract that gave the greatest reducing effect was the extract dose of 40mg/kgBB. 
Edukasi Pencegahan Penyakit Skabies Melalui Peer Educator Di Sekolah Enterpreneur Tahfidz Kekasih Al-Aqsha, Gowa, Sulawesi Selatan Muslimin, Lukman; Marwati, Marwati; Mus, Suwahyuni; Rosyid, Sujud Z; Irwana, Rina; Djamaluddin, Suci F; Khairi, Nur; Indrisari, Maulita; Nursamsiar, Nursamsiar; Megawati, Megawati; Imrawati, Imrawati; Nur, Syamsu; Sami, Fitriyanti; Amin, Astuti; Paluseri, Andi
Jurnal Pengabdian Kefarmasian Vol 4, No 2 (2023): JURNAL PENGABDIAN KEFARMASIAN
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/jpk.v4i2.3421

Abstract

Scabies Prevention Through Peer Educators At The Entrepreneur School Of Tahfidz Kekasih Al-Aqsha, Gowa, South SulawesiBased on a survey that was carried out, it was found that there were incidents of head lice and scabies infections at the Tahfidz Kekasih Al-Aqsa Entrepreneurial School, in Pattallassang, Kab. Gowa, South Sulawesi. This shows that the student's knowledge of this disease is still low. So it is necessary to carry out outreach to increase students' knowledge of the dangers of scabies and its treatment. 45 students and 5 teachers attended this counseling. The methods used in this service are lecture, question and answer, and scabies examination. The presentation of material about scabies was carried out using PowerPoint media, after which the material continued with a question-and-answer session. At the end of the activity, a health examination was carried out to identify and provide treatment to students and teachers who suffered from scabies. The results of the counseling showed that 2 students were suffering from scabies. The counseling was considered successful because the students answered all the questions (100%).Keywords: Counseling, Peer Education, Scabies Berdasarkan survei yang telah dilakukan ditemukan adanya kejadian infeksi kutu rambut dan skabies (kudis) di Sekolah Enterpreneur Tahfidz Kekasih Al-Aqsha, di Pattallassang, Kab. Gowa, Sulawesi Selatan. Hal ini menunjukkan masih rendahnya pengetahuan para santri terhadap penyakit tersebut. Maka perlu dilakukan sosialisasi untuk meningkatkan pengetahuan santri terhadap bahaya penyakit skabies serta pengobatannya. Penyuluhan ini diikuti oleh 45 orang santri dan 5 orang guru. Metode yang digunakan dalam pengabdian ini adalah metode ceramah, tanya jawab, dan pemeriksaan skabies. Pemaparan materi tentang skabies dilakukan menggunakan media PowerPoint, setelah pemaparan materi dilanjutkan dengan sesi tanya jawab. Di akhir kegiatan, dilakukan pemeriksaan kesehatan untuk mengetahui dan memberikan pengobatan kepada santri maupun guru yang menderita skabies. Hasil penyuluhan menunjukkan bahwa ada 2 orang santri yang menderita skabies. Penyuluhan dinilai berhasil karena semua pertanyaan yang diberikan berhasil dijawab oleh santri (100%).Kata kunci : Penyuluhan, Peer Education, Skabies
Identifikasi dan Penetapan Kadar Flavonoid Ekstrak Etil Asetat Daun Mimba (Azadiractha indica A. Juss) Metode Spektrofotometri UV- Vis Utami, Yuri Pratiwi; Imrawati, Imrawati; Mustarin, Rahmah; Mus, Suwahyuni; Jariah, Ainun
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1049

Abstract

Flavonoid terdiri dari 15 molekul yang tersusun dalam susunan C6-C3-C6 yang merupakan senyawa polifenol. Senyawa ini berbentuk kerangka karbon dan terurai menjadi dua set: C6 dan C3. Daun mimba (Azadiractha indica A. Juss) mengandung flavonoid yang memiliki sifat antioksidan, antibakteri, dan antikanker. Penelitian ini bertujuan untuk mengidentifikasi kelompok senyawa dalam daun mimba (Azadirachta indica A. Juss) dan menentukan kadar flavonoidnya. Ekstraksi dilakukan menggunakan teknik maserasi dengan pelarut etil asetat untuk mendapatkan ekstrak yang kemudian diuji melalui skrining fitokimia. Pengukuran kadar flavonoid dilakukan dengan metode spektrofotometri UV-Vis. Dari hasil ekstraksi, diperoleh rendemen ekstrak sebesar 5,83%. Hasil skrining fitokimia menunjukkan adanya kandungan flavonoid dan alkaloid. Kadar flavonoid ditentukan menggunakan kuersetin sebagai standar pembanding, dengan persamaan garis y = 0,0739x + 0,0776. Kesimpulannya, ekstrak etil asetat mengandung flavonoid dengan kadar 1,183 ± 0,018%.Flavonoids consist of 15 molecules arranged in a C6-C3-C6 configuration, which are polyphenolic compounds. These compounds form a carbon framework and are divided into two sets: C6 and C3. Neem leaves (Azadirachta indica A. Juss) contain flavonoids that have antioxidant, antibacterial, and anticancer properties. This study aims to identify the group of compounds in neem leaves (Azadirachta indica A. Juss) and determine their flavonoid content. Extraction was carried out using the maceration technique with ethyl acetate as a solvent to obtain an extract that was then tested through phytochemical screening. Flavonoid content was measured using the UV-Vis spectrophotometric method. The extraction process yielded an extract with a percentage of 5.83%. Phytochemical screening results indicated the presence of flavonoids and alkaloids. The flavonoid content was determined using quercetin as a reference standard, with the equation y = 0.0739x + 0.0776. In conclusion, the ethyl acetate extract contains flavonoids with a concentration of 1.183 ± 0.018%.
Peningkatan Pengetahuan Santri Tentang Dismenorea Dan Pencegahannya Melalui Tanaman Herbal Lukman, Lukman; Mus, Suwahyuni; Plasay, Makkasau
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/gkrsdn55

Abstract

Dismenorea atau nyeri haid merupakan keluhan ginekologi akibat ketidakseimbangan hormon progesteron dalam darah yang umumnya diderita oleh remaja. Dismenorea sangat mengganggu aktivitas belajar remaja sehari-hari karena mengakibatkan nyeri, pusing bahkan pingsan. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan santri tentang dismenorea dan cara pencegahannya menggunakan tanaman herbal. Kegiatan pengabdian ini dilaksanakan di Sekolah Entrepreneur Tahfidz Kekasih Al-Aqsa, Kab. Gowa, Sulawesi Selatan. Adapun metode yang dipergunakan adalah ceramah, diskusi, dan tanya jawab. Untuk mengukur pengetahuan santri telah dilakukan pre-tes dan post-tes. Soal dibagi menjadi 2 kelompok pertanyaan (10 soal tentang dismenorea dan 10 soal berikutnya tentang tanaman herbal berkhasiat pencegah dismenorea. Kegiatan ini ikuti oleh 45 orang santri yang terdiri dari santri tingkat SMP 20 orang dan SMA 25 orang. Hasil pre-tes menunjukkan bahwa sebagian besar santri (57,78%) tidak bisa membedakan antara nyeri haid dengan nyeri perut sedangkan pengetahuan santri terhadap tanaman herbal berkhasiat pencegah dismenorea juga sangat rendah (44,44). Kegiatan pengabdian ini dinilai berhasil karena hasil post-tes menunjukkan peningkatan nilai akhir yang signifikan. Pengetahuan santri terhadap dismenorea meningkat menjadi 100% sedangkan pengetahuan santri tentang herbal berkhasiat pencegah dismenorea menjadi 93,33%. Kebanyakan dari santri mengetahui bahwa bumbu dapur seperti kunyit, kencur, serai, dan asam jawa dapat dijadikan sebagai obat alternatif pencegah dismenorea. Diharapkan sinergi antara universitas dengan santri dapat lebih ditingkatkan terutama dalam pengolahan sampel herbal guna mendapatkan jamu atau ramuan yang terjaga kualitas dan keamanannya.
Diffusion Study of Cream Formula of Lyophilized Ethanol Extract of Moringa oleifera L. Leaves : Studi Difusi Formula Krim Ekstrak Etanol Terliofilisasi Daun Kelor (Moringa oleifera L.) Sapra, Amriani; Mus, Suwahyuni; Dwirandy, Dwirandy; Malluka, Rifka; Khairi, Nur
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15275

Abstract

Background: Moringa oleifera L. leaves have analgesic activity due to their flavonoids content. These polar antioxidants compounds usually have difficulty to diffuse through the skin. Objectives: The purpose of this study was to evaluate the diffusion parameters of cream contains the lyophilized of M. oleifera leaves ethanol extract. Material and Methods: The lyophilized of M.oleifera leaves ethanol extract (5%) formulated as an o/w cream with 2% of cetyl alcohol as a stiffening agent. The physical characteristics of the cream were determined for organoleptic, homogeneity, pH, viscosity, spreadability, and type of emulsion parameters. The diffusion parameters were determined with Franz cell diffusion using the skin's snake as a membrane with 0; 10; 30; 60 and 90 minutes sampling time. Results: Physical characteristics of the cream showed that o/w as the cream type with pH, viscosity, and spreadability value were 4.72±0.03; 14.000±225 cps; and 5.7±0.20 cm, respectively. The diffusion parameter showed total flavonoids penetrate through the membrane was 360.134±0.20 µg/cm2 with flux 239,875 µg/cm2hr. Conclusions: This study showed a cream formulation that fulfills the required physical characteristics standard and can deliver active compounds to penetrate through the membrane.
Penentuan Profil Metabolit dan Uji Aktivitas Antioksidan Pada Fraksi Daun Sawo Duren (Chrysophyllum Cainito L.) Agiel, Fadillah Maryam Bau; Umar, Abd. Halim; Ulfa, Maria; Mus, Suwahyuni; Imrawati, Imrawati
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.702

Abstract

Sawo duren (Chrysophyllum cainito L.) merupakan tanaman yang banyak digunakan dalam pengobatan, diantaranya antiinflamasi, antidiabetes dan sebagai antioksidan. Daun sawo duren mengandung senyawa saponin, triterpenoid, flavonoid, fenolik, serta alkaloid dan steroid. Tujuan dari penelitian ini adalah untuk mengalisis dan membandingkan profil metabolit fraksi n-Butanol daun sawo duren berdasarkan analisis FTIR. Proses ekstraksi daun sawo duren dilakukan dengan metode maserasi menggunakan pelarut etanol kemudian difraksinasi menggunakan pelarut etanol, n-heksan dan n-butanol. tahapan selanjutnya fraksi n-butanol dipilih untuk analisis FTIR. Hasil dari analisis spektrum untuk sampel fraksi daun sawo duren memiliki O-H (Fenol), C-H (Alkana), C-O (Alkohol), C=O (Aldehida), C=C (Alkena) terdeteksi pada sampel. Berdasarkan hasil data FTIR menunjukkan adanya gugus fungsi O-H yang diprediksi merupakan senyawa fenol, saponin dan tanin; C-H alkana diprediksi senyawa terpenoid dan steroid; C-H aromatic diprediksi senyawa fenol; dan C-O diprediksi senyawa flavonoid, alkaloid dan tanin.
The Effect of Ethanol Percentage on Antioxidant Activity of Celery (Apium graveolens) Lukman, Lukman; Mus, Suwahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.60387

Abstract

Excessive physical activity forms reactive oxygen species (ROS), which oxidize low-density lipoprotein (LDL) and trigger the formation of arteriosclerosis. Increasing antioxidant consumption, such as celery (Apium graveolens), has been proven to prevent heart disease. This study investigated the effect of ethanol concentration on the antioxidant activity of celery herbs in vitro and in vivo. The dried herb was macerated using a mixture of ethanol and water (100% water, 50% ethanol, 70% ethanol, 90% ethanol, and ethanol absolute (99,5%)). Antioxidant activity was determined using the LDL oxidation and β-carotene bleaching methods. Additionally, the antioxidant in vivo activity was carried out on rats using the high-intensity swimming exercises method. The results showed that 70% ethanol extract was significantly (p<0.05) able to inhibit the degradation of β-carotene and LDL oxidation compared to other extracts. The 70% ethanol extract also reduced malondialdehyde levels (14.35±0.63 ng/mL) compared to negative controls (46.04±1.69 ng/mL). In addition, there was an increase in glutathione levels after administration of 70% ethanol extract (111.93±11.68 ng/mL) compared to negative controls (46.04±1.69 ng/mL). In conclusion, 70% ethanol extract of celery herb has the potential to be developed as an alternative to prevent arteriosclerosis.
Fraksi Daun Andong Merah (Cordyline fruticose (L.) A. Cheval) Berpotensi sebagai Sitotoksik Metode BSLT Utami, Yuri Pratiwi; Imrawati, Imrawati; Mus, Suwahyuni; Astri, Andi Astri Sri Nurul Fardila; Mustarin, Rahmah
JOURNAL OF NONCOMMUNICABLE DISEASES Vol 4, No 1 (2024): April 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jond.v4i1.974

Abstract

Andong merah (Cordyline fruticosa (L.) A. Cheval) merupakan tanaman yang banyak digunakan sebagai obat tradisional. Kandungan senyawa yang ada pada tanaman andong merah berupa metabolit sekunder diantaranya polifenol, flavonoid, saponin, alkaloid, steroid dan triterpenoid sedangkan pada daun andong merah mengandung senyawa polifenol, tannin dan flavonoid. Tujuan dari penelitian ini yaitu untuk mengetahui sitotoksisitas fraksi daun andong merah (C. Fruticosa) terhadap larva udang Artemia salina Leach menggunakan metode BSLT. Ekstrak etanol 70% menghasilkan tiga fraksi yaitu fraksi n-heksan, fraksi etil asetat, dan fraksi etanol-air dengan teknik ekstraksi cair-cair (ECC) menggunakan tiga pelarut. Kemudian diuji sitotoksisitasnya dari seri konsentrasi 20 ppm, 40 ppm, 60 ppm, 80 ppm dan 100 ppm serta kontrol negatif. Hasil yang diperoleh dari penelitian ini berupa aktivitas sitotoksik fraksi dengan parameter nilai LC50 yaitu fraksi n-heksan 25,05 ppm ppm, fraksi etil aetat 85,21 ppm dan fraksi etanol-air 32,39 ppm. Kesimpulannya yakni fraksi dari daun andong merah (C. Fruticosa) termasuk dalam kategori sitotoksistas kuat. Cordyline fruticosa (L.) A. Cheval is a plant that is widely used as a traditional medicine. The compounds contained in the red oak plant are secondary metabolites including polyphenols, flavonoids, saponins, alkaloids, steroids and triterpenoids whereas in the leaves of the red andong contain compound polyphenol, tannins and flavanoids. The aim of the study was to determine the cytotoxicity of the C. fruticosa fraction to the larvae of the shrimp Artemia salina Leach using the BSLT method. The 70% ethanol extract produces three fractions namely the n-hexane fraction, the ethyl acetate fraction and the ethanole-water fraction using the liquid-liquid extraction technique (ECC) using three solvents. Then they tested their cytotoxicity from a series of concentrations of 20 ppm, 40 ppm and 60 ppm as well as negative controls. The results obtained from this study were fractional cytotoxic activity with LC50 parameters of 25.05 ppm n-hexane fraction, 85.21 ppm ethyl acetate fraction and 32.39 ppm ethanol-water fraction. The conclusion is that the fraction of the C. Fruticosa leaves belongs to the category of strong cytotoxists
Co-Authors Agiel, Fadillah Maryam Bau Ainun Jariah Astri, Andi Astri Sri Nurul Fardila Astuti Amin Djamaluddin, Suci F Dwirandy, Dwirandy Irwana, Rina Khairi, Nur Lukman Lukman LUKMAN, LUKMAN Malluka, Rifka Maria Ulfa Maryam, Fadhillah Mar’atun Jannah, Imrawati, Muzakkir Baitz, Maulita Indrisari, Maulita Megawati - Muslimin, Lukman Nursamsiar Nursamsiar paluseri, Andi Plasay, Makkasau Rahmah Mustarin Reny Syahruni Rosyid, Sujud Z Sami, Fitriyanti Sapra, Amriani Solly Aryza Surida, Surida Syamsu Nur, Syamsu Umar, Abd. Halim Utami, Yuri Pratiwi