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Jong, F.X. Himawan H.
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Medicine & Pharmacology Public Health

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Muntingia Calabura L. Leaves Extract Effect Towards Increment Of Nitric Oxide In Rattus Norvegicus Ivander, Gian; Isbandiati, Endang; Jong, F.X. Himawan H.
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 1, No 4 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.193 KB) | DOI: 10.33508/jwmj.v1i4.2248

Abstract

Introduction: Hypertension is one of the leading health problem in Indonesia. One of the pathophysiology of hypertension is abnormality in nitric oxide production and transport. On the other side, Muntingia calabura L. is a plant that widely distributed in Indonesian and believed to possessed antinociceptive, antioxidant, antihypertension, and antimicrobial effect. Leaves of Muntingia calabura L. comprise of high phenolic compounds which is thought to increase nitric oxide production through the modulation of NOS and ROS inhibition. Aim: To analyze the effect of extract of Muntingia calabura L. leaves toward increment of nitric oxide in Rattus norvegicus. Method: This research is an in vivo experimental study with post-test only control group design, using nitric oxide strips test as measuring instrument. Sample of this experiment is forty Rattus norvegicus divided in five group which is negative control, positive control, treatment 1, treatment 2, and treatment 3. Extract of Muntingia calabura L. leaves with concentration 50, 100, 200 mg/mL given everyday on treatment group and measured every two days until six measurement is acquired. Result: There is increment of NO through administration extract of Muntingia calabura L. leaves in Rattus norvegicus. Conclusion: Highest increment of NO is obtained through administration of Muntingia calabura L. leaves extract at 200 mg/mL concentration.
Antibacterial Effect Of Muntingia Calabura L. Leaf Extract To Pseudomonas Aeruginosa Anggono, Yovita; Jong, F.X. Himawan H.; Rahayu, Titien
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 1, No 4 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (651.803 KB) | DOI: 10.33508/jwmj.v1i4.2250

Abstract

Background: Pseudomonas aeruginosa is an opportunistic pathogen which can cause infection in every part of the human body lacking normal defense. This bacteria is one of the leading cause of nosocomial infection in Indonesia. Treating infection caused by Pseudomonas aeruginosa is now more challenging due to its resistance to many classes of antibiotics. On the other hand, Muntingia calabura L. is a genus of plants in the family Elaeocarpaceae, which is spread widely throughout South East Asia, including Indonesia. Some of the researches in the past show antibacterial properties of these plants. Aim: to determine the antibacterial effect of Muntingia calabura L. Leaf extract to Pseudomonas aeruginosa. Method: This research is an experimental study using in vitro technique and non-equivalent control group design. The method used in this study was microdilution in 96-well microplate and concentrations of Muntinga calabura L. Leaf extract used in this study were 50-800mg/mL. Minimum Inhibitory Concentration (MIC) was measured by a spectrophotometer, while Minimum Bactericidal Concentration (MBC) was observed by direct streaking to the agar plate. Result: MIC value was found at the concentration range of 400-800 mg/mL, while MBC was found at concentration 800 mg/mL. Conclusion: There is a potential bactericidal effect of Muntingia calabura L. To Pseudomonas aeruginosa
Co-Authors Anggono, Yovita Isbandiati, Endang Ivander, Gian Rahayu, Titien