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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Respirasi (JR)
Febriani, Anna
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Decision Sciences, Operations Research & Management Health Professions Medicine & Pharmacology Public Health

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Journal : Jurnal Respirasi (JR)

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Monitoring and Evaluation of Therapy Response in Advanced-Stage Lung Cancer Treated with Systemic Therapy Syamsuri, Ibrahim; Febriani, Anna; Wulandari, Laksmi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.183-190

Abstract

Lung cancer is the second most commonly diagnosed malignancy, with the highest mortality rate in the world. In Indonesia, lung cancer ranks third with 34,783 cases, contributing to the highest number of deaths due to cancer. Most patients are diagnosed at an advanced stage, requiring systemic therapy. Therapeutic modalities for lung cancer patients can include surgery, radiotherapy, and systemic therapy, with the choice of therapy determined by the histological type, disease stage, laboratory results, performance status (PS), and comorbidities. This situation requires regular monitoring and evaluation to reduce the symptoms and improve the patient’s quality of life (QoL). Therapy response in systemic therapy patients can be evaluated through subjective, semi-subjective, and objective evaluations. Subjective evaluation involves monitoring QoL, focusing on cancer outcomes, and patients’ well-being. Semi-subjective evaluation consists of monitoring the patient’s weight and PS. Objective evaluation uses imaging equipment, such as computed tomography (CT) scans, fluoroscopy, magnetic resonance imaging (MRI), and positron emission tomography (PET) scans to monitor tumor progression.
Primary Pulmonary Myxoid Sarcoma: A Rare and Challenging Diagnosis in Thoracic Oncology Apriyanto, Yudi; Febriani, Anna; Wulandari, Laksmi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.69-74

Abstract

Introduction: Primary pulmonary myxoid sarcoma (PPMS) is a rare malignant mesenchymal lung tumor, with fewer than 40 cases reported worldwide. This care report presented a case of PPMS with surgical difficulties. Case: A 53-year-old man presented with a six-month history of exertional dyspnea, coughing up blood, right chest pain, anorexia, and weight loss. Thoracic computed tomography (CT) imaging revealed an enhancing solid mass in the middle-posterior mediastinum. Histopathological examination of a core biopsy identified anaplastic lipoblast cells indicative of liposarcoma. Based on the multidisciplinary team (MDT) discussion, the patient was diagnosed with mediastinal liposarcoma, and tumor excision was planned. However, during the surgery, a lung tumor with adhesions to the middle and lower lobes of the right lung was discovered, precluding the complete tumor. An open biopsy was performed instead, revealing a proliferation of anaplastic cells with round to oval spindle nuclei arranged reticularly within a myxoid stroma, along with positive Alcian blue staining. Immunohistochemical analysis demonstrated focal desmin positivity in the cytoplasm of the tumor cells. The diagnosis of PPMS was confirmed based on the criteria by the World Health Organization (WHO) in 2021, including primary lung tumor, spindle-shaped and round tumor cells in a reticular pattern within a myxoid stroma, and immunohistochemical findings that exclude other histologically similar tumors. Conclusion: Although rare, PPMS should be considered in the differential diagnosis of thoracic tumors. Most PPMS patients were treated surgically and had a good prognosis. However, tumor excision could not be performed in this patient due to the adhesion of the tumor mass to the middle and lower lobes of the right lung.
Co-Authors Apriyanto, Yudi Atik, Nurul Hariputri, Wulan Rahmawati Laksmi Wulandari Novananda, Donny Ardika Resti Yudhawati Riyanto, Shandy Billy Syamsuri, Ibrahim Thendeyas, Richar Tomy Wati, Farah Fatma