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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Respirasi (JR) Pharmaceutical Sciences and Research (PSR)
Febriani, Anna
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Decision Sciences, Operations Research & Management Health Professions Medicine & Pharmacology Public Health

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Screening Lung Cancer in Sampang Regency, Madura Through Empowerment and Health Cadres Formation Yudhawati, Resti; Wulandari, Laksmi; Febriani, Anna; Wati, Farah Fatma; Thendeyas, Richar Tomy; Atik, Nurul; Hariputri, Wulan Rahmawati; Novananda, Donny Ardika; Riyanto, Shandy Billy
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 10, No 2 (2024): June
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.92549

Abstract

Treatment for lung cancer remains challenging since most of the patients seek medical advice at an advanced stage of disease. Sampang is one of the regencies that refers many lung cancer patients in late stages to Dr. Soetomo Hospital, Surabaya, due to lack of information of lung cancer and early detection. Limited number of health workers to deliver comprehensive education to all areas requires community volunteers to fill this gap. The objective of this study was to educate and promote lung cancer awareness to the health cadres in Sampang as well as training them to early detecting individuals in the community with high-risk factors, as an attempt to bridge between the health workers and community, therefore the number of lung cancer early detection may be improved. Early identification of cancer may result in reduced morbidity and mortality, and in some cases, if detected early enough, therapy may involve only surgery.  The education was provided for the health cadres by providing information related to lung cancer and guidance to fill the questionnaire and scoring of lung cancer risk factors. The participants' understanding was measured using a pretest-posttest design. Thirty health cadres have been successfully formed, and they have gained knowledge of lung cancer and mastered capability to perform early-screening of lung cancer in the community as shown by the increase of post-test result compared to pre-test. The health cadres then implemented their knowledge of lung cancer early-screening by distributing questionnaires of lung cancer risk factor scoring to residents using door to door methods. The questionnaires’ evaluation collected by the health cadres showed that there were 93 residents with high-risk factors of lung cancer.  In conclusion, the health cadres has been capable to detect high-risk factors individuals in the community which further be followed up by community health workers comprehensively.
Monitoring and Evaluation of Therapy Response in Advanced-Stage Lung Cancer Treated with Systemic Therapy Syamsuri, Ibrahim; Febriani, Anna; Wulandari, Laksmi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.183-190

Abstract

Lung cancer is the second most commonly diagnosed malignancy, with the highest mortality rate in the world. In Indonesia, lung cancer ranks third with 34,783 cases, contributing to the highest number of deaths due to cancer. Most patients are diagnosed at an advanced stage, requiring systemic therapy. Therapeutic modalities for lung cancer patients can include surgery, radiotherapy, and systemic therapy, with the choice of therapy determined by the histological type, disease stage, laboratory results, performance status (PS), and comorbidities. This situation requires regular monitoring and evaluation to reduce the symptoms and improve the patient’s quality of life (QoL). Therapy response in systemic therapy patients can be evaluated through subjective, semi-subjective, and objective evaluations. Subjective evaluation involves monitoring QoL, focusing on cancer outcomes, and patients’ well-being. Semi-subjective evaluation consists of monitoring the patient’s weight and PS. Objective evaluation uses imaging equipment, such as computed tomography (CT) scans, fluoroscopy, magnetic resonance imaging (MRI), and positron emission tomography (PET) scans to monitor tumor progression.
Primary Pulmonary Myxoid Sarcoma: A Rare and Challenging Diagnosis in Thoracic Oncology Apriyanto, Yudi; Febriani, Anna; Wulandari, Laksmi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.69-74

Abstract

Introduction: Primary pulmonary myxoid sarcoma (PPMS) is a rare malignant mesenchymal lung tumor, with fewer than 40 cases reported worldwide. This care report presented a case of PPMS with surgical difficulties. Case: A 53-year-old man presented with a six-month history of exertional dyspnea, coughing up blood, right chest pain, anorexia, and weight loss. Thoracic computed tomography (CT) imaging revealed an enhancing solid mass in the middle-posterior mediastinum. Histopathological examination of a core biopsy identified anaplastic lipoblast cells indicative of liposarcoma. Based on the multidisciplinary team (MDT) discussion, the patient was diagnosed with mediastinal liposarcoma, and tumor excision was planned. However, during the surgery, a lung tumor with adhesions to the middle and lower lobes of the right lung was discovered, precluding the complete tumor. An open biopsy was performed instead, revealing a proliferation of anaplastic cells with round to oval spindle nuclei arranged reticularly within a myxoid stroma, along with positive Alcian blue staining. Immunohistochemical analysis demonstrated focal desmin positivity in the cytoplasm of the tumor cells. The diagnosis of PPMS was confirmed based on the criteria by the World Health Organization (WHO) in 2021, including primary lung tumor, spindle-shaped and round tumor cells in a reticular pattern within a myxoid stroma, and immunohistochemical findings that exclude other histologically similar tumors. Conclusion: Although rare, PPMS should be considered in the differential diagnosis of thoracic tumors. Most PPMS patients were treated surgically and had a good prognosis. However, tumor excision could not be performed in this patient due to the adhesion of the tumor mass to the middle and lower lobes of the right lung.
The Chemotherapy Use and Adverse Effects of Patients with Lung Cancer at Regional General Hospital in Surabaya, Indonesia Yulia, Rika; Kirtishanti, Aguslina; Wijono, Heru; Setiawan, Eko; Presley, Bobby; Go, Tjie Kok; Mayani, Ni Putu Irma; Febriani, Anna; Jaya, Halim Priyahau; Herawati, Fauna
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In Indonesia, lung cancer is the leading cause of death related to cancer, according to Global Cancer Observatory. Chemotherapy is the most common treatment since it works systemically and can prevent cancer cells from spreading to other organs. Cytotoxicity of chemotherapy can also put patients at high risk of experiencing adverse effects. This study aimed to evaluate the congruity of chemotherapy use with treatment recommendations and the profile of adverse effects, not only acute but also delayed adverse drug reactions. This prospective observational study involved 41 adult patients with lung cancer who received chemotherapy. Data is collected through patients’ medical records, brief patient interviews, and analyzed descriptively. The majority of the patients received first-line chemotherapy (87.80%). Pemetrexed-cisplatin (39.02%) and pemetrexed-carboplatin (19.51%) are the most common first-line therapy, followed by docetaxel (12,20%) as the second-line chemotherapy commonly used by patients. The chemotherapy regimens used in patients were 100% appropriate based on treatment guidelines. 61.11% and 60% of patients experience adverse effects with the first and second line of chemotherapy, respectively. Anemia (63,89%) was the most common delayed adverse effect in the first-line chemotherapy and hair loss (60%) was the most common one in the second-line chemotherapy. The platinum-based chemotherapy is a standard treatment for lung cancer, but its tolerability limits its uses. These findings showed chemotherapy-related adverse effects that need to be considered in choosing the best choice of therapy to optimize the treatment. Therefore, prophylaxis therapy to manage chemotherapy-related adverse effects may be considered in patients with chemotherapy.
Co-Authors Aguslina Kirtishanti Apriyanto, Yudi Atik, Nurul Bobby Presley, Bobby Eko Setiawan Go, Tjie Kok Hariputri, Wulan Rahmawati Herawati, Fauna Jaya, Halim Priyahau Laksmi Wulandari Mayani, Ni Putu Irma Novananda, Donny Ardika Resti Yudhawati Rika Yulia Riyanto, Shandy Billy Syamsuri, Ibrahim Thendeyas, Richar Tomy Wati, Farah Fatma Wijono, Heru