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All Journal MNJ (Malang Neurology Journal) Biomolecular and Health Science Journal Jurnal Keperawatan Health Dynamics
Sugondo, Alexander Tikara
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Health Dynamics

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How Do Maternal Gestational Diabetes and Preterm Premature Rupture of Membrane (PROM) Contribute to Neonatal Jaundice and Sepsis? A Case Report and Narrative Review Mustikasari, Melisa Indah; Pamungkas, Aditya Fendi Uji; Sugondo, Alexander Tikara; Putri, Made Chindy Dwiyanti Marheni; Azkia, Razita Aulia
Health Dynamics Vol 2, No 3 (2025): March 2025
Publisher : Knowledge Dynamics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hd20304

Abstract

Gestational diabetes mellitus (GDM) and preterm premature rupture of membranes (PPROM) are significant obstetric conditions associated with heightened maternal and neonatal morbidity and mortality. Globally, complications of preterm birth, particularly due to PPROM, account for 35% of neonatal deaths. The coexistence of GDM and PPROM compounds risks, exacerbating adverse neonatal outcomes. This report about a 21 years old primigravida at 32–34 weeks of gestation with untreated GDM and PPROM for over 12 hours. The patient presented with decreased fetal movement and was managed conservatively with corticosteroids, antibiotics, and tocolytics. However, signs of fetal distress necessitated cesarean delivery, resulting in the birth of a male neonate 2370 g, APGAR 2/3, with asphyxia, respiratory distress, and hypoglycemia. Postnatal complications included jaundice and neonatal sepsis, which required 22 days of intensive NICU care with respiratory support, dextrose infusion, and antibiotics. The neonate showed gradual improvement. The coexistence of GDM and PPROM significantly increases the risk of adverse neonatal outcomes such as respiratory distress, hypoglycemia, jaundice, and sepsis. Early diagnosis, glycemic control, prophylactic antibiotics, and administration of corticosteroids are critical to improving maternal and neonatal outcomes. This case underscores the importance of a multidisciplinary approach and further research to refine best practices in managing GDM complicated by PPROM.
Spontaneous Conception and Favorable Obstetric Outcome in a Patient with PCOS and Class II Obesity: A Case Report Mustikasari, Melisa Indah; Wardhana, Manggala Pasca; Indriani, Anin; Sugondo, Alexander Tikara; Putri, Made Chindy Dwiyanti Marheni
Health Dynamics Vol 2, No 4 (2025): April 2025
Publisher : Knowledge Dynamics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hd20404

Abstract

Polycystic ovary syndrome (PCOS) and obesity are prevalent conditions that independently impair fertility and increase the risk of adverse pregnancy outcomes. When coexisting, they present compounded challenges for conception and pregnancy management. We report a case of a 27-year-old primigravida with PCOS and class II obesity who achieved spontaneous conception after three years of infertility and multiple failed assisted reproductive attempts. Preconception lifestyle modifications and medical management improved insulin sensitivity and restored ovulatory function. Despite being categorized as a high-risk pregnancy, the antenatal course was unremarkable, with appropriate fetal growth and no major maternal or neonatal complications. Vaginal delivery occurred at term, resulting in a healthy newborn. This case highlights the potential for favorable reproductive and obstetric outcomes in women with PCOS and obesity through early diagnosis, lifestyle intervention, and meticulous prenatal care. It underscores the importance of individualized and multidisciplinary management strategies in optimizing maternal and fetal health. Spontaneous conception and favorable pregnancy outcomes are achievable in women with PCOS and obesity through comprehensive care. Early intervention and tailored monitoring play a crucial role in mitigating risks associated with these conditions.
Co-Authors Ardiany, Deasy Artama, Marvell Aurelinus Ayunani, Nadia Noorbertha Azkia, Razita Aulia Husni, Nadya Indriani, Anin Machin, Abdulloh Mustikasari, Melisa Indah Notopuro, Pulus Budiono Nuswantoro, Djohar Pamungkas, Aditya Fendi Uji Primadana, Aditya Putri, Made Chindy Dwiyanti Marheni Savitri, Kania Aviandi Setjaputra, Vina Lidya Susianto, Steven Christian Wardhana, Manggala Pasca