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All Journal Folia Medica Indonesiana Jurnal NERS MNJ (Malang Neurology Journal) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology AKSONA Asian Journal of Health Research
Machin, Abdulloh
3Departement Of Neuorology, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Correlation between Hyperglycemia Stress and Short-Term Memory Function in Thrombotic Stroke Patients Muhammad Hamdan1, Riani Wisnujono1, Yudha Haryono1, Abdulloh Machin1, Dian Puspitarini1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3194

Abstract

Background: Hyperglycemic stress is associated with a disorder of the entire cognitive domain in the early phase of stroke, which is memory impairment. Acute changes in blood glucose are known to affect the cerebral blood flow. Objectives: To determine the relationship between stress hyperglycemia with short-term memory function in thrombotic stroke patients. Method: An observational analytic research with the case-control with a patient’s of 72-hour onset thrombotic stroke that went to the Emergency Unit and was admitted to the Neurology Department of Dr. Soetomo General Hospital from January to December 2014. 42 subjects were enrolled (21 subjects in the case group and 21 subjects in the control group). The sampling of the study was conducted according to the cases that came in succession until the achievement of the subject was determined. Results: After bivariate and multivariate analysis, hyperglycemic stress had no significant correlation to memory function (p = 0.525) and OR 0.667 (CI95% = 0.190-2.334). There was a significant correlation between educational level and cognitive function (p = 0.003) also between hypertension and cognitive function (p = 0.019). Conclusion: Stress Hyperglycaemia has no significant relationship with memory function. Education levels and hypertension have a significant correlation with memory function.
Associaton between Blood Total Testosterone Levels and Consolidated Memory on Eldery Men at Veterans Institution Muhammad Hamdan1 , Raini Wisnujono1 , Yudha Haryono1 , Abdulloh Machin2 , Euginia Putri Permata P.2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10767

Abstract

Background: Decreased total testosterone levels in the blood will disrupt memory consolidation. In this phase, one could still function normally even though it is difficult to recall the information that has been learned. Methods: The subjects were taken consecutively and conducted by interview, generalist, and neurological physical examination, Word List Memory Task examination twice as well as measurement of total testosterone in the blood. The subjects were grouped into total blood testosterone levels of less than 298 ng/ dl and more than equal to 298 ng/dl. Results: Fifty-four subjects studied obtained that total blood testosterone levels <298 ng/dl in the Word List Memory Task (WLMT) group <21 (62.5%) were higher than the WLMT group ?21 (37.5%). Furthermore, Total Testosterone in the blood more ?298 ng/dl in the WLMT group <21 (15.2%) was less than in the WLMT group ?21 (84.8%). Conclusion: There was a correlation between total testosterone levels in the blood and memory consolidation in elderly men at the Veterans’ Institute of Republic Indonesia in Surabaya.
DEMENTIA IN DR. SOETOMO GENERAL HOSPITAL SURABAYA: A SYNTHETIC REVIEW OF ITS CHARACTERISTICS Imami, Nabilah Hasna; Haryono, Yudha; Sensusiati, Anggraini Dwi; Hamdan, Muhammad; Hidayati, Hanik Badriyah
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.3

Abstract

Background: Dementia is a clinical syndrome characterized by progressive loss of cognitive function in elderly people interferes  the ability to function independently. The number of elderly patients increased so fast in worldwide. The prevalence of dementia rapidly increases due to increasing of population. Aging demographic transition is proceeding rapidly especially in China, India, and Latin America, where dementia is rapidly becoming the major public health problem. Demographic data of elderly patients of dementia in Indonesia is still a little. Dementia’s research data in Indonesia were only obtained  from Bali and Yogyakarta, while data from Surabaya were not obtained. Our research data is taken from Dr. General Hospital Soetomo Surabaya, East Java, Indonesia. This study is important for dementia epidemiological data and baseline data for further treatment of dementia patients in Surabaya.Objective: The purpose of this study to determine the characteristics profile of elderly patients  with dementia in Dr. Soetomo General Hospital Surabaya, East Java, Indonesia.Methods: Sampling was done with purposive sampling by observing the medical records of patients in the period of January 2017 to December 2017 based on inclusion and exclusion criterias that have been set. The data was taken from the patient's medical record which had been written and examined by neurologists from the neurology department in the neurobehaviour sub-department of Dr. Soetomo Surabaya.Results: The majority of dementia patients are men (51,7%); the age group which is most at risk for dementia is between age of  75-79 years; most of the patients are jobless; more than half of patients are high school graduates; and Vascular Dementia (VaD) is the type of dementia that  most people suferredConclusion: This characteristic’s data of dementia can be used for providing information about dementia to make public health care provides a better facillities and treatment for elderly patients to prevent dementia burden.
Correlation between High Sensitivity-Crp Level and Executive Function Disorders in Elderly Patients Muhammad Hamdan1 , Joseph Ekowahono Rahardjo1 , Yudha Haryono1 , Devi Ariani Sudibyo1 , Dyah Anetta
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10691

Abstract

Background: C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the frontal-subcortical circuit. Objective: To determine the correlation between high serum concentration of hs-CRP and executive function disorder in elderly patients. Method: Thirty six elderly patients was examined by using a case control study. The subjects were enrolled from the out-patient at Neurology Departement Dr. Soetomo General Hospital, Surabaya, Indonesia. The time period was 4 months (April to July 2015). Executive function was measured with the Trail Making Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis. Results: Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%) subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0,538-58,860). Conclusion: These data suggested that high levels of hs-CRP was not associated with executive function in elderly patients.
PROFILE OF EPILEPSY PATIENTS IN PEDIATRIC WARD AT DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA IN THE PERIOD OF JANUARY-DECEMBER 2017 Dewi Sekarsari; Viskasari P. Kalanjati; Abdulloh Machin; Prastiya I. Gunawan
Majalah Biomorfologi Vol. 30 No. 2 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v30i2.2020.34-38

Abstract

Background: Various risk factors of epilepsy in children had been reported although differences were found amongst regions. Objective: To identify the profile of epilepsy patients and previous febrile seizure history in children aged 0-17 years at Pediatric Ward, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2017. Materials and Methods: This was a cross-sectional retrospective study, using secondary data from medical records of epilepsy patients with febrile seizure history in children aged 0-17 years old at Pediatric Ward, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in the period of January-December 2017. Data analysis was done using t-test and Chi- Square test (Microsoft Excel 2007 and SPSS 22). The level of significance was p<0.05. Results: Seventy-four male and 38 female patients were included. Febrile seizure history was observed in 42 patients and there was no significant difference between febrile seizure history and prevalence of epilepsy. The general type of seizure was found in 79 patients; mostly from Surabaya, Indonesia and the parents’ occupation was private employee. The most observed type of seizure was general type. Conclusion: In this study, epilepsy was predominantly found in males than females; and a significant number of the patients were without febrile seizure history. General type of seizure was the most common type amongst others. These patients were mostly from Surabaya, Indonesia, whose parents' occupation was private employees.
Penyakit Parkinson: Tinjauan Tentang Salah Satu Penyakit Neurodegeneratif yang Paling Umum Safia Alia; Hanik Badriyah Hidayati; Muhammad Hamdan; Priya Nugraha; Achmad Fahmi; Agus Turchan; Yudha Haryono
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.044 KB) | DOI: 10.20473/aksona.v1i2.145

Abstract

Penyakit Parkinson (PP) adalah penyakit neurodegeneratif paling umum ke dua yang melibatkan hilangnya neuron dopaminergik di otak tengah yang menyebabkan gejala motorik dan nonmotorik pada pasien yang mengalaminya. Gejala motorik ini dapat dikelola dan dikendalikan dalam  jangka waktu tertentu dengan menggunakan obat-obatan seperti levodopa. PP mempengaruhi jutaan orang di seluruh dunia, oleh karena itu tinjauan pustaka tinjauan pustaka tentang PP menjadi penting dan kami akan menyampaikan berbagai hal penting dari PP mulai dari patofisiologi hingga tindakan pengobatan baik medikamentosa maupun tindakan intervensi.
Are Abbreviated Mental Test (AMT) and Ascertain Dementia 8 Indonesia (AD8-INA) Questionnaires More Superior than Mini-Mental State Examination (MMSE) as Dementia Screening Instrument among Elderly in Rural Areas? Jovian Philip Swatan; Yudha Haryono
AKSONA Vol. 2 No. 1 (2022): JANUARY 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.016 KB) | DOI: 10.20473/aksona.v2i1.210

Abstract

Introduction: Dementia screening provides numerous benefits to its users. However, current screening methods have several limitations regarding applicability and accuracy, making it difficult to accommodate the results. Objective: To describe whether the Abbreviated Mental Test (AMT) and Ascertain Dementia 8 Indonesia (AD8-INA) questionnaire is superior to Mini-Mental State Examination (MMSE) questionnaire as a dementia screening instrument for the elderly in rural areas. Methods: A cross-sectional study was conducted in February 2020 at Banyuwangi residence. Dementia screening was conducted among elderly respondents using MMSE, AMT, and AD8-INA questionnaires. Sensitivity and specificity of AMT, AD8-INA and combined AMT+AD8-INA were compared with the MMSE questionnaire using crosstabs. Comparison of time required to complete each questionnaire was analyzed using Wilcoxon Signed Rank Test. Results: Mean age among 59 respondents was 68.44 years. The average MMSE score was 24.54. Compared with MMSE, the AMT questionnaire had a sensitivity of 47.37% and specificity of 100% (X2 = 22.36, p <0.001). Meanwhile, the AD8-INA questionnaire had a sensitivity of 63.16% and specificity of 45% (X2 = 24.64, p <0.001). The average questionnaire completion time of AMT, AD8-INA, and combined AMT+AD8-INA each was significantly shorter than MMSE (122.59, 121.17, and 243.76 seconds vs 319.83 seconds, p<0.001, <0.001, and <0.001, respectively). Conclusion: This study found that the combined AMT+AD8-INA questionnaire could be used as a dementia screening instrument among the elderly in rural areas with considerable sensitivity and shorter administration time.  
Multiple Sistem Atrophy: Sebuah Laporan Kasus Edfina Rahmarini; Muhammad Hamdan; Priya Nugraha; Paulus Sugianto; Yudha Haryono
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.173 KB) | DOI: 10.20473/aksona.v1i1.102

Abstract

Pendahuluan: Multiple sistem atrophy adalah penyakit degeneratif yang dapat menyebabkan kecacatan bahkan kematian. Sedikit jurnal yang yang membahas tentang diagnosis dan penanganan multiple system atrophy secara menyeluruh. Kasus: Seorang laki-laki berusia 44 tahun datang ke poli saraf dengan keluhan kelemahan pada keempat ekstremitas dengan disertai gejala parkinsonisme yang khas. Pada pemeriksaan neurologis didapatkan gangguan fungsi serebelum. Pada pemeriksaan MRI kepala dengan kontras didapatkan gambaran khas suatu multipel system atrophy tipe cerebellar. Kesimpulan: Multipel system atrophy adalah kasus degeneratif yang bersifat jarang namun seringkali dapat menyebabkan kematian. Dibutuhkan diagnosis yang cepat dan penanganan yang memadai secara multidisiplin untuk mencegah beratnya gejala multiple system atrophy. Terapi simptomatik dan suportif sangat dibutuhkan untuk meningatkan kualitas hidup pasien.
Komorbiditas Pasien Demensia di RSUD Dr. Soetomo Periode Januari–Desember 2017 Nabilah Hasna Imami; Yudha Haryono; Anggraini Dwi Sensusiati; Muhammad Hamdan; Hanik Badriyah Hidayati
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.436 KB) | DOI: 10.20473/aksona.v1i1.95

Abstract

Pendahuluan: Demensia merupakan proses hilangnya fungsi kognitif seperti berpikir, mengingat, dan bernalar sehingga penderita demensia terganggu dalam melakukan kehidupan dan aktivitas sehari-hari pada seseorang. WHO menyebutkan bahwa jumlah pasien demensia di dunia terus meningkat. Pada tahun 2015, pasien demensia diprediksi mencapai 47,47 juta pasien dan dapat mencapai 75,63 juta pada 2030. Semakin meningkat usia lansia, faktor komorbiditas yang menyerang lansia juga semakin meningkat. Faktor komorbiditas dapat berupa penyakit kronik seperti stroke, hipertensi, DM, juga penyakit jantung. Tujuan: Untuk mengetahui prevalensi komorbiditas pada pasien lansia demensia di RSUD Dr. Soetomo Surabaya. Metode: Data diambil dari rekam medis pasien pada periode Januari hingga Desember 2017 di RSUD Dr. Soetomo Surabaya berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil: Faktor komorbiditas yang paling banyak terjadi pada pasien demensia adalah stroke (57,3%), diikuti oleh hipertensi (50,6%), DM (30,3%), penyakit Parkinson (24,7%), dan penyakit Jantung (19,1%). Kesimpulan: Stroke merupakan komorbiditas paling banyak terjadi pada pasien dengan demensia. Hipertensi berada di tempat kedua paling banyak diderita lansia demensia. Pengendalian komorbiditas pada lansia sangat penting untuk dilaksanakan untuk mengendalikan risiko terjadinya penurunan fungsi kognitif.
Analysis of Potential Cinnamomum zeylanicum Blume Essential Oil Against Alzheimer's Disease: A Molecular Docking Study Muhammad Ja'far Shodiq; Farmindo Hartono; Siti Khaerunnisa; Abdulloh Machin
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 1 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i12023.111-125

Abstract

Background: Alzheimer's Disease (AD) is a neurodegenerative disorder with progressive impairment of behavioural and cognitive functions and the most common cause of dementia. The pathophysiology of AD is associated with low acetylcholine, accumulation of amyloid beta plaque, and neurofibrillary tangles in the brain. Cinnamomum zeylanicum is known to have many medicinal properties, especially neuroprotective effects. Objective: This research was designed to determine the neuroprotective potential of the phytochemicals C. zeylanicum using an in silico study. Methods: There are 5 phytochemicals compounds of C. zeylanicum used in this study. It's qualified for Lipinski's rules of five and can cross blood brain barrier. The protein targets were AChE, BACE1, and GSK-3. Molecular docking and visualization were performed using Avogadro, AutoDock 4.2 PyMol and Biovia Discovery Studio 2019. Results: In silico results show that the main phytochemical compounds of C. zeylanicum Blume essential oil have great potency as an AD drug. The best interaction model of the compound was shown by trans-cinnamyl acetate and coumaric acid. Although the binding energy of the compounds is lower than AD drugs (donepezil, rivastigmine, galantamine), the binding energy is not much different from rivastigmine and galantamine. Conclusion: The phytochemical compounds of C. zeylanicum Blume essential oil have an effect as a neuroprotective agent for AD and should be investigated in future research.
Co-Authors Afif Nurul Hidayati, Afif Nurul Alia, Safia Anny Hanifah Aris Widayati Arlia Ayu Damayanti Ayu Imamatun Nisa Azizah Amimathul Firdha Baarid Luqman Hamidi Basuki, Mudjiani Beom Joon Kim Christrijogo Soemartono Waloejo Dedy Kurniawan Devi Ariani Sudibyo Dewi Sekarsari Didik Hasmono Djoko Agus Suprapto Edfina Rahmarini Fahmi Achmad Faisal Fahmi, Achmad Farmindo Hartono Farmindo Hartono Fauzi, Asra Al Fedik Abdul Rantam Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Husni, Nadya Imami, Nabilah Hasna Isti Suharjanti Jakfar Shodiq Jeffri Nagasastra Jenar Harumi Jovian Philip Swatan M Fata Fatihuddin Meo, Maria Lettisia Mohammad Fathul Qorib Muhammad Hamdan Muhammad Hamdan Muhammad Ja'far Shodiq Muhammad Ja'far Shodiq Nabilah Hasna Imami Nadiva, Shafa Karin Nugraha, Priya Paulus Sugianto Paulus Sugianto, Paulus Pearl Dhodik Wirasman Prastiya I. Gunawan Priya Nugraha Rahmarini, Edfina Retnaningsih Safia Alia Savira Dienanta Sensusiati, Anggraini Dwi Setjaputra, Vina Lidya Shodiq, Muhammad Ja'far Siti Khaerunnisa Siti Khaerunnisa Soetjipto Soetjipto Steven Christian Susianto Sugondo, Alexander Tikara Susianto, Steven Christian Swatan, Jovian Philip Talaway, Athalia Anastasia Turchan, Agus Vina Lidya Setjaputra Viskasari P. Kalanjati Wibi Riawan