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All Journal Interdental Jurnal Kedokteran Gigi (IJKG) MDJ (Makassar Dental Journal)
Ni Nyoman Gemini Sari
Faculty Of Dentistry, Universitas Mahasaraswati Denpasar
Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology Public Health

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Comparative Effects of 50% and 100% Pleurotus ostreatus Gel on TNF-α in Traumatic Ulcer Healing in Wistar Rats Ni Nyoman Gemini Sari; Raziv Ganesha; Ni Nyoman Linda Pradnya Ningsih
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 1 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i1.12362

Abstract

Introduction: White oyster mushroom (Pleurotus ostreatus) is a natural ingredient with diverse benefits, including its ability to heal traumatic ulcers. In the healing process, TNF-α acts as an inflammatory mediator that promotes epithelial growth and neovascularization. Material and Methods: This study was an in vivo laboratory experimental study using a post-test only control group approach, involving 32 samples randomly divided into eight treatment groups (n=4) based on variations in gel concentration (50%, 100%, negative control, and positive control) and observation time (days 3 and 7). TNF-α expression measurements were performed using an ELISA kit. Research data were analysed using the parametric One-Way ANOVA test, the non-parametric Kruskal-Wallis and Mann-Whitney tests, followed by the Tukey Post-Hoc test. Results and Discussions: Statistical analysis results showed a p-value of 0.000 <0.05 between treatment groups. Tumor Necrosis Factor-Alpha (TNF-α) expression decreased significantly in the groups given 50% and 100% white oyster mushroom extract gel, with the lowest average found at a concentration of 50% on both days 3 and 7, namely 231.33 and 195.33, thus demonstrating more optimal effectiveness at that concentration. Conclusion: White oyster mushroom (Pleurotus ostreatus) extract gel at a concentration of 50% was more effective than a concentration of 100% in reducing TNF-α expression in the healing of traumatic ulcers in male wistar rats. Further research with a concentration range of 50-100% and other immunological parameters is required for further confirmation.
Effect Of Moringa oleifera Extract Gel on Macrophage Cells in Diabetic Traumatic Ulcer Healing Raziv Ganesha; I Gusti Ngurah Putra Dermawan; Ni Nyoman Gemini Sari; Agung Wira Trystano Kepakisan
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 1 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i1.13588

Abstract

Introduction: Traumatic ulcers are common oral mucosal lesions caused by mechanical injury. In diabetes, wound healing is delayed due to impaired immune responses, including macrophage dysfunction. Moringa oleifera leaves contain flavonoids, tannins, phenols, and saponins that have anti-inflammatory and wound-healing properties. This study evaluated the effect of Moringa oleifera extract gel on macrophage cell counts during traumatic ulcer healing in diabetic male Wistar rats. Materials and Methods: This experimental study used a post-test-only control group design with 32 male Wistar rats. Diabetes was induced using streptozotocin (STZ). Traumatic ulcers were created on the labial mucosa using a burnisher. Rats were divided into four treatment groups (P1–P4) receiving Moringa oleifera extract gel and four control groups (K1–K4) receiving 3% Na-CMC gel. Observations were conducted on days 3, 5, 7, and 9. Gel was applied three times daily. Tissue samples were processed histologically, stained with hematoxylin-eosin, and examined for macrophage counts. Results: Mean macrophage counts in treatment groups were P1=11.45, P2=10.15, P3=12.33, and P4=10.28, while control groups were K1=5.65, K2=6.70, K3=7.65, and K4=10.25. One-Way ANOVA showed significant differences among groups (p=0.021). Tukey Post Hoc analysis revealed a significant difference between P3 and K1 (p=0.037). Pearson correlation showed a significant negative correlation (r=-0.357; p=0.045). Conclusion: Moringa oleifera extract gel significantly affected macrophage cell counts during traumatic ulcer healing in diabetic male Wistar rats.
Co-Authors Agung Wira Trystano Kepakisan Della Yudi Ardana Dewi, Intan Kemala I Gusti Ngurah Putra Dermawan I Gusti Ngurah Putra Dermawan I Gusti Ngurah Putra Dermawan I Gusti Ngurah Rai Diky Dermawan I Nyoman Gede Juwita Putra Intan Kemala Dewi Komang Ayudita Trimulyani Ni Komang Alisya Ni Nyoman Linda Pradnya Ningsih Ni Putu Andini Dewi Febriyanti Ni Putu Widani Astuti Pande I Putu Andika Prasetiawan Raziv Ganesha Trimulyani , Komang Ayudita