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All Journal Interdental Jurnal Kedokteran Gigi (IJKG) MDJ (Makassar Dental Journal)
Ni Nyoman Gemini Sari
Faculty Of Dentistry, Universitas Mahasaraswati Denpasar
Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology Public Health

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Treatment of Burning Mouth Syndrome Accompanied With Xerostomia and Dysgeusia in Diabetes Mellitus Patients Raziv Ganesha; Ni Nyoman Gemini Sari; I Nyoman Gede Juwita Putra
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 1 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i1.11175

Abstract

Introduction: Burning mouth syndrome is pain in the oral mucosa with or without signs of or without specific signs of lesions. The manifestations of Diabetes in the oral cavity are xerostomia, dysgeusia and burning mouth syndrome. Purpose of this case report is to describe the management of Burning mouth syndrome cases accompanied by Xerostomia and Dysgeusia in patients with Diabetes. Case: A 65-year-old woman presented with complaints of pain felt was a burning sensation on the tongue. patient felt the burning pain during a day but also at night for the past 2 weeks. Case Treatment: The diagnosis in this case is Burning mouth syndrome accompanied by Xerostomia due to Diabetes. Patient was given oxyfresh® for 3x 10 ml and Becomzet® 1x1. The patient had DL, GDP (110), GD2PP (145), HbA1C (7.2), SGOT (27), and SGPT (29) and Sialometry (0.3ml). Patient accepted the treatment and followed the instructions given. Patient was healed on the third visit. Discussions: Burning mouth syndrome is a burning and uncomfortable or stinging feeling with a normal clinical feature. Xerostomia and Dysgeusia are often concurrent symptoms so it is called the triad symptom of burning mouth syndrome. Treatment with oxyfresh® which contains xylitol as an antimicrobial that reduces the risk of caries, zinc acetate which is effective in maintaining oral moisture and aloe is useful for reducing irritation, pain and inflammation so as to reduce pain in burning mouth syndrome. Conclusion: Treatment in this case was successful with good cooperation from the patient to accelerate healing.
Effectiveness of inhibition of telang flower (Clitoria ternatea L.) against the growth of Candida albicans: Efektivitas daya hambat bunga telang (Clitoria ternatea L.) terhadap pertumbuhan Candida albicans Ni Nyoman Gemini Sari; Intan Kemala Dewi; Pande I Putu Andika Prasetiawan
Makassar Dental Journal Vol. 12 No. 3 (2023): Volume 12 Issue 3 Desember 2023
Publisher : Makassar Dental Journal PDGI Makassar

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Abstract

Kandidiasis oral adalah infeksi oportunistik yang paling umum memengaruhi mukosa mulut. Dalam sebagian besar kasus, lesi disebabkan oleh Candida albicans. Banyak obat antijamur yang telah banyak diproduksi dan dijual di pasaran untuk mengobati kandidiasis, namun obat-obatan tersebut memiliki efek samping. Salah satu tumbuhan yang dapat dibudidayakan sebagai tanaman hias dan tanaman obat adalah kembang telang (Clitoria ternatea L.). Diketahui daya hambat bunga telang terhadap C.alcans disebabkan oleh zat antosianin. Penelitian eksperimental ini dirancang dengan post-test only control group. Uji KruskalWallis menunjukkan perbedaan yang signifikan efektivitas ekstrak bunga telang 50%, 75%, 100% dalam membunuh koloni C.albicans. Uji Mann Whitney tidak mendapatkan perbedaan yang signifikan ekstrak bunga telang 50%, 75%, 100% dalam membunuh koloni C.albicans; keduanya pada media SDA. Konsentrasi bunga telang yang terus ditingkatkan mengalami penurunan efektivitas. Disimpulkan bahwa makin tinggi konsentrasi daya difusi ekstrak ke dalam media berkurang sehingga semakin rendah kelarutannya.
Comparative Effects of 50% and 100% Pleurotus ostreatus Gel on TNF-α in Traumatic Ulcer Healing in Wistar Rats Sari, Ni Nyoman Gemini; Ganesha, Raziv; Ningsih, Ni Nyoman Linda Pradnya
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 1 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i1.12362

Abstract

Introduction: White oyster mushroom (Pleurotus ostreatus) is a natural ingredient with diverse benefits, including its ability to heal traumatic ulcers. In the healing process, TNF-α acts as an inflammatory mediator that promotes epithelial growth and neovascularization. Material and Methods: This study was an in vivo laboratory experimental study using a post-test only control group approach, involving 32 samples randomly divided into eight treatment groups (n=4) based on variations in gel concentration (50%, 100%, negative control, and positive control) and observation time (days 3 and 7). TNF-α expression measurements were performed using an ELISA kit. Research data were analysed using the parametric One-Way ANOVA test, the non-parametric Kruskal-Wallis and Mann-Whitney tests, followed by the Tukey Post-Hoc test. Results and Discussions: Statistical analysis results showed a p-value of 0.000 <0.05 between treatment groups. Tumor Necrosis Factor-Alpha (TNF-α) expression decreased significantly in the groups given 50% and 100% white oyster mushroom extract gel, with the lowest average found at a concentration of 50% on both days 3 and 7, namely 231.33 and 195.33, thus demonstrating more optimal effectiveness at that concentration. Conclusion: White oyster mushroom (Pleurotus ostreatus) extract gel at a concentration of 50% was more effective than a concentration of 100% in reducing TNF-α expression in the healing of traumatic ulcers in male wistar rats. Further research with a concentration range of 50-100% and other immunological parameters is required for further confirmation.
Effect Of Moringa oleifera Extract Gel on Macrophage Cells in Diabetic Traumatic Ulcer Healing Ganesha, Raziv; Dermawan, I Gusti Ngurah Putra; Sari, Ni Nyoman Gemini; Kepakisan, Agung Wira Trystano
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 1 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i1.13588

Abstract

Introduction: Traumatic ulcers are common oral mucosal lesions caused by mechanical injury. In diabetes, wound healing is delayed due to impaired immune responses, including macrophage dysfunction. Moringa oleifera leaves contain flavonoids, tannins, phenols, and saponins that have anti-inflammatory and wound-healing properties. This study evaluated the effect of Moringa oleifera extract gel on macrophage cell counts during traumatic ulcer healing in diabetic male Wistar rats. Materials and Methods: This experimental study used a post-test-only control group design with 32 male Wistar rats. Diabetes was induced using streptozotocin (STZ). Traumatic ulcers were created on the labial mucosa using a burnisher. Rats were divided into four treatment groups (P1–P4) receiving Moringa oleifera extract gel and four control groups (K1–K4) receiving 3% Na-CMC gel. Observations were conducted on days 3, 5, 7, and 9. Gel was applied three times daily. Tissue samples were processed histologically, stained with hematoxylin-eosin, and examined for macrophage counts. Results: Mean macrophage counts in treatment groups were P1=11.45, P2=10.15, P3=12.33, and P4=10.28, while control groups were K1=5.65, K2=6.70, K3=7.65, and K4=10.25. One-Way ANOVA showed significant differences among groups (p=0.021). Tukey Post Hoc analysis revealed a significant difference between P3 and K1 (p=0.037). Pearson correlation showed a significant negative correlation (r=-0.357; p=0.045). Conclusion: Moringa oleifera extract gel significantly affected macrophage cell counts during traumatic ulcer healing in diabetic male Wistar rats.
Co-Authors Ayu Ratih Kusuma Dewi Della Yudi Ardana Dermawan, I Gusti Ngurah Putra Dewi, Intan Kemala I Gusti Ngurah Putra Dermawan I Gusti Ngurah Putra Dermawan I Gusti Ngurah Putra Dermawan I Gusti Ngurah Rai Diky Dermawan I Nyoman Gede Juwita Putra Intan Kemala Dewi Intan Kemala Dewi Kepakisan, Agung Wira Trystano Komang Ayudita Trimulyani Ni Komang Alisya Ni Putu Andini Dewi Febriyanti Ni Putu Widani Astuti Ningsih, Ni Nyoman Linda Pradnya Pande I Putu Andika Prasetiawan Pande I Putu Andika Prasetiawan Raziv Ganesha Trimulyani , Komang Ayudita