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All Journal JTIK (Jurnal Teknik Informatika Kaputama) Jurnal Indah Sains dan Klinis
Siregar, Suci Rahmadani
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Computer Science & IT Dentistry Health Professions Medicine & Pharmacology Nursing

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ADMET Prediction Compounds of Polar Extract Curcuma rhizoma Sumardi, Sumardi; Suprianto, Suprianto; Siregar, Suci Rahmadani; Zai, Arifin Putra; Tambubolon, Regina Elianda; Mairani, Fridelly
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.01

Abstract

The pharmacokinetic and metabolic profiles of polar extract compounds from Curcuma rhizoma were evaluated using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions. Most compounds exhibited high gastrointestinal (GI) absorption, with the exception of D-glucose, citric acid, and terpenoids such as alpha-pinene and zingiberene, which demonstrated low absorption, highlighting potential challenges for systemic bioavailability. Blood-brain barrier (BBB) permeability was observed in lipophilic compounds like xanthorrhizol, bisdemethoxycurcumin, and terpenoids, suggesting their potential for CNS-targeted therapies, while polar compounds, including D-glucose, citric acid, and most curcuminoids, were non-permeant. D-glucose was the only compound identified as a P-glycoprotein (Pgp) substrate, indicating minimal efflux-related limitations for other compounds. Selective cytochrome P450 (CYP) enzyme inhibition was detected in compounds such as xanthorrhizol, curcuminoids, and zingiberene, suggesting potential metabolic interactions in multi-drug contexts. Promising therapeutic candidates include curcuminoids and xanthorrhizol, while non-BBB-permeant and low-absorbing compounds may require formulation strategies or alternative applications. These findings provide valuable insights into the pharmacological optimization of Curcuma rhizoma compounds, offering a foundation for further research in drug discovery and development.
SISTEM PENDUKUNG KEPUTUSAN PEMBERIAN KREDIT PNS DENGAN METODE AHP DAN TOPSIS (Studi Kasus : PT. Bank Sumut Cabang Binjai) Siregar, Suci Rahmadani; Nurhayati, Nurhayati
JTIK (Jurnal Teknik Informatika Kaputama) Vol. 2 No. 1 (2018): Volume 2, Nomor 1, Januari 2018
Publisher : STMIK KAPUTAMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59697/jtik.v2i1.671

Abstract

Prosedur pemberian kredit pada Bank Sumut didalamnya mencakup pengecekan serta pengambilan keputusan. Sistem yang sedang berjalan dalam pemberian kredit masih secara manual dengan menggunakan Ms.Excel, selain itu membutuhkan waktu yang tidak sedikit dalam mengambil keputusan untuk memecahkan masalah dan menjadi alasan mengapa pembangunan sistem yang baru perlu dilakukan.Sistem Pendukung Keputusan (SPK) adalah sistem yang dapat membantu para pengambil keputusan dalam mengambil keputusan yang akurat dan tepa. Tujuan pembentukan sistem Pendukung Keputusan (SPK) adalah memanfaatkan keunggulan manusia dan Perangkat elektronik untuk memecahkan berbagai masalah yang ada.Metode yang digunakan dalam pembuatan Sistem Pendukung Keputusan ini adalah metode AHP dan TOPSIS. Kedua metode ini merupakan metode yang sering digunakan untuk menyelesaikan beberapa masalah berupa perangkingan , kedua metode ini dipilih karena sistem komputasinya sederhana dan mudah dimengerti, sehingga sistem ini dapat dijadikan bahan pertimbangan dalam menentukan berapa besar kredit yang akan diberikan.
Penetapan Kadar Total Fenol dan Total Flavonoid pada Lotion Berbahan Ekstrak Daun Sisrsak (Annona muricata) dan Kulit Buah Naga Merah (Hylocereus polyrhizus) Menggunakan Spektrofotometri UV–VIS Siregar, Suci Rahmadani; Suprianto; Chandra Pranata; Marbun, Intan Coni Caroline
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.04

Abstract

Background: Phenolic and flavonoid compounds from soursop (Annona muricata) leaves and red dragon fruit (Hylocereus polyrhizus) peel have potential applications in lotion formulations; therefore, their quantification is important for quality evaluation. Objective: To determine total phenolic content (TPC) and total flavonoid content (TFC) in lotion formulations containing combined plant extracts and to assess the analytical method performance. Method; Four formulations were prepared: F0 (without extract), F1 (0.5% + 0.5%), F2 (1.0% + 1.0%), and F3 (1.5% + 1.5%). TPC was measured using the Folin–Ciocalteu method (mg GAE/g) and TFC using the AlCl₃ colorimetric method (mg QE/g). Method validation included repeatability (%RSD, n = 6) and spike-recovery accuracy at 80–120%. Results: The method showed good precision (%RSD 1.08% for TPC and 1.21% for TFC) and acceptable accuracy with recoveries of 98–102%. F0 showed non-detectable values, while increasing extract concentration resulted in higher TPC (3.82 ± 0.14 to 9.71 ± 0.33 mg GAE/g) and TFC (0.86 ± 0.05 to 2.35 ± 0.10 mg QE/g). Differences among formulations were statistically significant (p < 0.05). Conclusion: The UV–Vis method is suitable for determining TPC and TFC in lotion matrices, and higher levels of combined extracts significantly increase both parameters, supporting their use for quality standardization of herbal lotions.
Co-Authors Chandra Pranata Fridelly Mairani Apt Marbun, Intan Coni Caroline Nurhayati Nurhayati Sumardi . Suprianto Suprianto Tambubolon, Regina Elianda Zai, Arifin Putra