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All Journal CALYPTRA : Jurnal Ilmiah Mahasiswa Universitas Surabaya MPI (Media Pharmaceutica Indonesiana) JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Islamie, Ridho
Faculty Of Pharmacy, University Of Surabaya Jl. Raya Kalirungkut Surabaya 60294
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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EFEKTIVITAS PENGAWET PADA PRODUK LOKAL EYELINER WATERPROOFTERHADAP PERTUMBUHAN Pseudomonas aeruginosadan Candida albicans YANG DIJUAL DI PASAR BLAURAN KOTA SURABAYA Habiba M. Assegaf; Christina Avanti; Ridho Islamie
CALYPTRA Vol. 7 No. 2 (2019): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (Maret)
Publisher : Perpustakaan Universitas Surabaya

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Abstract

Abstract – The purpose of this study was to test the effectiveness of preservatives on waterproof eyeliner sold in Pasar Blauran Surabaya. The method used in this research is Total Plate Numbers (ALT) using Nutrient Agar (NA) media for Pseudomonas aeruginosa and Saboraud Dextrose Agar with addition of antibiotic (SDAa) for Candida albicans to obtain a 5,6 x 108CFU / ml suspension for Pseudomonas aeruginosa and 2.0 x 107 CFU / ml for Candida albicans. Then the suspension was added to the sample, then observed the growth of bacterial colony and yeast on the 2nd and 7th day. The result obtained is no growth of Pseudomonas aeruginosa and Candida albicans on day 2 and 7, so preservative in the sample can be said to be effective in inhibiting the growth of bacteria and yeasts.
Formulation and pH-Physical Stability Evaluation of Gel and Cream of Plantago major Leaves Extract Kartini Kartini; Babtista Merchyta Winarjo; Endang Wahyu Fitriani; Ridho Islamie
MPI (Media Pharmaceutica Indonesiana) Vol. 1 No. 3 (2017): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.981 KB) | DOI: 10.24123/mpi.v1i3.330

Abstract

Plantago major has been widely used for wound healing. This activity is supported by empiricalas well as preclinical data. The aims of this study were to (1) formulate Plantago major leaves extracts(PMLE) into topical dosage forms i.e. creams and gels and; (2) evaluate the pH and physical stability of theproducts. The results showed that creams and gels of PMLE were able to maintain the pH, visual appearance,flow properties, droplet size, and type of emulsion under accelerated (40±2 °C; 75±5% RH for 1.5 months)as well as room temperature (27 °C; 85% RH for 1.5 months) stability testing conditions. However, viscosityof creams significantly changed under those conditions. Even though the viscosity of gels was unstableunder accelerated condition, it was stable under room temperature storage. It is concluded that PMLEcould be formulated into creams or gels dosage forms and further optimisation should be conducted.
Keterlibatan Sistem MonoamineINVOLVEMENT OF MONOAMINERGIC SYSTEM IN THE ANTIDEPRESSANT-LIKE EFFECT OF Ocimum sanctum (LINN.) LEAVES EXTRACT IN TArgik pada Efek Antidepresan dari Ekstrak Daun Ocimum Sanctum (Linn.) terhadap Model Hewan Tail Suspention Test Ridho Islamie; Havid Ro’is; Intan Tristianti; Muhammad Helmi; Devyani Diah Wulansari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.157 KB) | DOI: 10.36387/jiis.v6i1.653

Abstract

Depression is a psychiatric disorder characterized by decreased mood and affects daily activities.The development of herbal ingredients as complementary therapy becomes increasing in line with the number of patients who avoid side effects in conventional treatment.The purpose of this study is to investigate the potential effects of ethanolic extract of Ocimum sanctumL. as an antidepressant as well as evaluate the potential mechanism of action in the monoaminergic system in invivo study.For evaluation of mechanisms of action, mice were treated serotonin synthesis inhibitors (pCPA), non-selective dopamine antagonists (Haloperidol) and selective antagonists D2 dopamine (Sulpiride) as pre-treatment.The Tail Suspension Test(TST)method is used as a standardized test that has generally been used to evaluate the antidepressant effects of a drug compound. The results showed that the ethanolic extract of OcimumsanctumL. has antidepressant effect at the dose of 150 mg/kg.Ethanol extract of OcimumsanctumL. was able to decrease the immobility time in TST mice model significantly when given pre-treatmentwith pCPA (p<0.05) and haloperidol (p<0.05), while sulpiride (p<0.05) inhibits the antidepressant effects of ethanolic extract of OcimumsanctumL. significantly.These results showed that the monoaminergic system especially serotonergic and dopaminergic were involved in the antidepressant-like effects of ethanolic extract of OcimumsanctumL. by involving dopamine receptors and has a role in serotonin synthesis.
Antibacterial Activity of Drosera Sp. Ethanolic Extract Against Staphylococcus Aureus ATCC 25923 Krisnawan, Alfian Hendra; Islamie, Ridho; Putri, Rahma Dhianitasari Wahyu; Dewi, Ni Putu Citra Ratna
JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Vol 8, No 1 (2023): Januari 2023
Publisher : Universitas Al Azhar Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36722/sst.v8i1.1494

Abstract

Drosera sp. is an insectivorous plant with secondary metabolites, including naphthoquinones which can be used as antibacterial agents. Staphylococcus aureus is a bacterium that often causes nosocomial infections, such as ARI. This research aims to determine the antibacterial activity of four Drosera species, namely D. burmannii, D. sessilifolia, D. capillaris, and D. filiformis, against Staphylococcus aureus ATCC 25923. The agar diffusion method was employed in antibacterial testing by measuring the inhibition zone. The inhibition zone measured using a 7,000 ppm concentration of Drosera sp. ethanolic extract was 6.74 ± 0.21 mm, 9.21 ± 0.32 mm, 18.18 ± 0.60 mm, and 15.67 ± 0.37 mm for D. burmannii, D. sessilifolia, D. capillaris, and D. filiformis, respectively. The largest value was produced by D. capillaris which was close to 19.73 ± 0.55 mm from the positive control (chloramphenicol). The four Drosera sp. extracts have antibacterial potential against Staphylococcus aureus ATCC 25923.Keywords – Antibacterial activity, Drosera sp., Staphylococcus aureus
Profil Resistensi Isolat Klebsiella pneumoniae, Haemophilus sp. dan Streptococcus viridans dari Sputum Pasien ISPA terhadap Amoksisilin Raharjo, Dian Natasya; Islamie, Ridho; Wahjudi, Mariana; Apriyani, Dhea Orinta; Wartini, Luh Risma; Dewi, Ni Putu Nila Sulistia
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.6523

Abstract

Infeksi Saluran Pernapasan Akut (ISPA) merupakan radang akut yang disebabkan oleh infeksi mikroorganisme dengan angka kejadian cukup tinggi di Indonesia. Sebanyak total 49 bakteri yang terdiri dari 13 isolat Klebsiella pneumoniae, 18 isolat Haemophilus sp., dan 18 isolat Streptococcus viridans koleksi laboratorium setempat diperoleh dari sputum pasien ISPA di berbagai puskesmas di Kota Surabaya selama bulan Desember 2022. Penelitian ini bertujuan untuk mengetahui resistensi dari 49 koleksi isolat tersebut terhadap amoksisilin. Pengujian dilakukan untuk memperoleh MIC (Minimum Inhibitory Concentration) amoksisilin menggunakan metode agar dilution pada media Mueller Hinton Agar. Nilai MIC kemudian dibandingkan dengan MIC breakpoints pada Clinical and Laboratory Standards Institute (CLSI) dan European Committee on Antibiotic Susceptibility Testing (EUCAST). Hasil penelitian menunjukkan 61,54% (8/13) isolat Klebsiella pneumoniae, 100% (18/18) isolat Haemophilus sp., dan 11,11% (2/18) isolat Streptococcus viridans resisten terhadap amoksisilin. Oleh karena itu dapat disimpulkan perlunya rekomendasi antibiotik alternatif sebagai pengganti amoksisilin untuk pengobatan ISPA. Acute Respiratory Infection (ARI) is an acute inflammation caused by microorganism infection with a high incidence in Indonesia. The local microbiology laboratory had successfully collected 49 bacterial isolates from the ARI patient's sputum in various Public Health Centers in Surabaya, Indonesia during December 2022. The isolates consisted of 13 isolates of Klebsiella pneumoniae, 18 isolates of Haemophilus sp., and 18 isolates of Streptococcus viridans. This study aimed to determine the resistance of the 49 isolates to amoxicillin. Testing was carried out to obtain the MIC (Minimum Inhibitory Concentration) of amoxicillin using the agar dilution method on Mueller Hinton Agar media. The MIC value was then compared with the MIC breakpoints at the Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antibiotic Susceptibility Testing (EUCAST). The results showed that 61.54% (8/13) of Klebsiella pneumoniae isolates, 100% (18/18) of Haemophilus sp. isolates, and 11.11% (2/18) of Streptococcus viridans isolates were resistant to amoxicillin. Therefore, it can be concluded that it is necessary to recommend alternative antibiotics as a substitute for amoxicillin for the treatment of ARI.
Co-Authors Apriyani, Dhea Orinta Babtista Merchyta Winarjo Christina Avanti Devyani Diah Wulansari Dewi, Ni Putu Citra Ratna Dewi, Ni Putu Nila Sulistia Endang Wahyu Fitriani Habiba M. Assegaf Havid Ro’is Intan Tristianti Kartini Kartini Krisnawan, Alfian Hendra Mariana Wahjudi, Mariana Muhammad Helmi Putri, Rahma Dhianitasari Wahyu Raharjo, Dian Natasya Wartini, Luh Risma